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Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy

Clinical cancer research, 2016-07, Vol.22 (14), p.3425-3431

2016

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Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1-Negative Human Lung Cancers

Clinical cancer research, 2018-04, Vol.24 (8), p.1954-1964

2018

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The third group of the B7‐CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7‐H3

Immunological reviews, 2017-03, Vol.276 (1), p.26-39

2017

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Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models

Cellular & molecular immunology, 2019-12, Vol.16 (12), p.908-920

2019

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The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy

Nature communications, 2022-05, Vol.13 (1), p.2506-15, Article 2506

2022

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The B7 Family and Cancer Therapy: Costimulation and Coinhibition

Clinical cancer research, 2007-09, Vol.13 (18), p.5271-5279

2007

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Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Journal of hematology and oncology, 2019-06, Vol.12 (1), p.59-20, Article 59

2019

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New immunotherapies targeting the PD-1 pathway

Trends in pharmacological sciences (Regular ed.), 2015-09, Vol.36 (9), p.587-595

2015

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HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status

Clinical cancer research, 2017-02, Vol.23 (3), p.825-832

2017

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Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

Scientific reports, 2016-07, Vol.6 (1), p.30093-30093, Article 30093

2016

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B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients

Clinical cancer research, 2016-06, Vol.22 (11), p.2778-2790

2016

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HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.9879-9884

2013

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The Contrasting Role of B7-H3

Proceedings of the National Academy of Sciences - PNAS, 2008-07, Vol.105 (30), p.10277-10278

2008

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Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein

Clinical cancer research, 2015-05, Vol.21 (10), p.2359-2366

2015

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The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+ T cells are important in maintaining normal pregnancy

Cell death & disease, 2019-05, Vol.10 (6), p.407-407, Article 407

2019

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Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell–mediated antitumor immunity

The Journal of clinical investigation, 2022-11, Vol.132 (22), p.1-17

2022

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Macrophage plasticity and function in cancer and pregnancy

Frontiers in immunology, 2024-01, Vol.14, p.1333549

2024

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TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells

Nature communications, 2024-01, Vol.15 (1), p.11-11, Article 11

2024

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Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer

Cell death & disease, 2020-09, Vol.11 (9), p.753-753, Article 753

2020

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Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4+T cells

Cell death & disease, 2019-01, Vol.10 (1), p.15-15, Article 15

2019

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Immune checkpoint pathways in glioblastoma: a diverse and evolving landscape

Frontiers in immunology, 2024-09, Vol.15, p.1424396

2024

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HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Oncoimmunology, 2015-08, Vol.4 (8), p.e1026534-e1026534

2015

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B7-H3 and B7x Are Highly Expressed in Human Prostate Cancer and Associated with Disease Spread and Poor Outcome

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (49), p.19458-19463

2007

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HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

British journal of cancer, 2020-04, Vol.122 (8), p.1211-1218

2020

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A review of the PD-1/PD-L1 checkpoint in bladder cancer: From mediator of immune escape to target for treatment

Urologic oncology, 2017-01, Vol.35 (1), p.14-20

2017

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Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy

Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1-Negative Human Lung Cancers

The third group of the B7‐CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7‐H3

Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models

The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy

The B7 Family and Cancer Therapy: Costimulation and Coinhibition

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

New immunotherapies targeting the PD-1 pathway

HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

The Contrasting Role of B7-H3

Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein

The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+ T cells are important in maintaining normal pregnancy

Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell–mediated antitumor immunity

Macrophage plasticity and function in cancer and pregnancy

TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells

Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer

Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4+T cells

Immune checkpoint pathways in glioblastoma: a diverse and evolving landscape

HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

B7-H3 and B7x Are Highly Expressed in Human Prostate Cancer and Associated with Disease Spread and Poor Outcome

HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

A review of the PD-1/PD-L1 checkpoint in bladder cancer: From mediator of immune escape to target for treatment

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