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Strategies for designing synthetic immune agonists

Immunology, 2016-08, Vol.148 (4), p.315-325

Wu, Tom Y.‐H.

2016

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Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5868-5878

2016

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A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877

ChemMedChem, 2020-08, Vol.15 (16), p.1562-1570

2020

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Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules

ChemMedChem, 2016-06, Vol.11 (11), p.1129-1132

2016

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Rational design of small molecules as vaccine adjuvants

Science translational medicine, 2014-11, Vol.6 (263), p.263ra160

2014

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Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes

ACS omega, 2019-02, Vol.4 (2), p.3571-3581

2019

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Synthetic Small Molecules That Control Stem Cell Fate

Proceedings of the National Academy of Sciences - PNAS, 2003-06, Vol.100 (13), p.7632-7637

2003

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Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus

Hepatology communications, 2019-10, Vol.3 (10), p.1296-1310

2019

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A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells

Human vaccines & immunotherapeutics, 2015-08, Vol.11 (8), p.2038-2050

2015

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One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines

Organic letters, 2003-10, Vol.5 (20), p.3587-3590

2003

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Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators

Journal of pharmaceutical sciences, 2018-09, Vol.107 (9), p.2310-2314

2018

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A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and β-Carbolines

Organic letters, 2002-11, Vol.4 (23), p.4033-4036

2002

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Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6978-6982

2010

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Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles

Organic letters, 2001-11, Vol.3 (24), p.3827-3830

2001

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Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.449-453

2004

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Abstract 684: Gastrointestinal/liver-targeted TLR7 agonist for treatment of colorectal and liver cancers

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.684-684

2020

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Pancreas-Specific Delivery of [beta]-Cell Proliferating Small Molecules

ChemMedChem, 2016-06, Vol.11 (11), p.1129

2016

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Biarylimidazoles as inhibitors of microsomal prostaglandin E 2 synthase-1

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6978-6982

2010

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Topical SMIP-7.7, a Toll–Like Receptor 7 Agonist, Protects against Genital Herpes Simplex Virus Type-2 Disease in the Guinea Pig Model of Genital Herpes

Antiviral chemistry & chemotherapy, 2014-10, Vol.23 (5), p.189-196

2014

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Applying chemical tools to the discovery of novel regenerative medicine

Drug discovery today. Technologies, 2006, Vol.3 (3), p.255-260

2006

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Biarylimidazoles as inhibitors of microsomal prostaglandin E sub(2) synthase-1

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6978-6982

2010

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Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction

Chemistry & biology, 2003-08, Vol.10 (8), p.759-767

2003

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A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification

Chemistry & biology, 2005, Vol.12 (1), p.55-63

2005

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2 - Target validation in chemogenomics

Target Validation in Drug Discovery, 2007, p.27-39

2007

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Strategies for designing synthetic immune agonists

Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide

A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877

Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133

Rational design of small molecules as vaccine adjuvants

Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes

Synthetic Small Molecules That Control Stem Cell Fate

Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus

A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells

One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines

Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators

A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and β-Carbolines

Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1

Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles

Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group

Abstract 684: Gastrointestinal/liver-targeted TLR7 agonist for treatment of colorectal and liver cancers

Pancreas-Specific Delivery of [beta]-Cell Proliferating Small Molecules

Biarylimidazoles as inhibitors of microsomal prostaglandin E 2 synthase-1

Topical SMIP-7.7, a Toll–Like Receptor 7 Agonist, Protects against Genital Herpes Simplex Virus Type-2 Disease in the Guinea Pig Model of Genital Herpes

Applying chemical tools to the discovery of novel regenerative medicine

Biarylimidazoles as inhibitors of microsomal prostaglandin E sub(2) synthase-1

Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction

A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification

2 - Target validation in chemogenomics

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