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Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

Acta pharmaceutica Sinica. B, 2020-07, Vol.10 (7), p.1294-1308

2020

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One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides

Organic letters, 2018-04, Vol.20 (7), p.1712-1715

2018

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Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Acta pharmaceutica Sinica. B, 2021-06, Vol.11 (6), p.1617-1628

2021

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Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Acta pharmaceutica Sinica. B, 2019-01, Vol.9 (1), p.144-156

2019

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A novel route for the synthesis of androgen receptor antagonist enzalutamide

Chinese chemical letters, 2023-06, Vol.34 (6), p.108096-453, Article 108096

2023

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Tackling Fungal Resistance by Biofilm Inhibitors

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2193-2211

2017

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Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Angewandte Chemie International Edition, 2020-02, Vol.59 (8), p.3028-3032

International ed. in English, 2020

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Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7245-7260

2018

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Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT)

Journal of medicinal chemistry, 2022-06, Vol.65 (11), p.7619-7628

2022

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Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer

Journal of medicinal chemistry, 2020-01, Vol.63 (2), p.696-713

2020

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Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4818-4831

2022

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Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

Organic letters, 2016-03, Vol.18 (5), p.1028-1031

2016

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Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound

European journal of medicinal chemistry, 2021-08, Vol.220, p.113544-113544, Article 113544

2021

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Programming Affinity for Precise Tumor Recognition with Allosteric Nanosensing-Circles

ACS nano, 2023-07, Vol.17 (14), p.13430-13440

2023

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Iridium-Catalyzed Enantioselective and Diastereoselective Allylation of Dioxindoles: A One-Step Synthesis of 3‑Allyl-3-hydroxyoxindoles

Organic letters, 2018-10, Vol.20 (19), p.6183-6187

2018

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Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors

European journal of medicinal chemistry, 2020-09, Vol.201, p.112515-112515, Article 112515

2020

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Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

ACS medicinal chemistry letters, 2018-04, Vol.9 (4), p.312-317

2018

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A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine

Nucleic acids research, 2022-09, Vol.50 (16), p.9039

2022

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Divergent Cascade Construction of Skeletally Diverse "Privileged" Pyrazole-Derived Molecular Architectures

European journal of organic chemistry, 2015-03, Vol.2015 (9), p.2030-2037

2015

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Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer

ACS medicinal chemistry letters, 2020-04, Vol.11 (4), p.439-444

2020

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Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity

Bioorganic & medicinal chemistry letters, 2020-01, Vol.30 (1), p.126662-126662, Article 126662

2020

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Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors

Bioorganic chemistry, 2022-05, Vol.122, p.105702-105702, Article 105702

2022

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Frontispiece: Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Angewandte Chemie International Edition, 2020-02, Vol.59 (8), p.n/a

International ed. in English, 2020

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Novel spiropyrazolone antitumor scaffold with potent activity: Design, synthesis and structure–activity relationship

European journal of medicinal chemistry, 2016-06, Vol.115, p.141-147

2016

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Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

ChemMedChem, 2018-01, Vol.13 (1), p.30-36

2018

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Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

A novel route for the synthesis of androgen receptor antagonist enzalutamide

Tackling Fungal Resistance by Biofilm Inhibitors

Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT)

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer

Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound

Programming Affinity for Precise Tumor Recognition with Allosteric Nanosensing-Circles

Iridium-Catalyzed Enantioselective and Diastereoselective Allylation of Dioxindoles: A One-Step Synthesis of 3‑Allyl-3-hydroxyoxindoles

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine

Divergent Cascade Construction of Skeletally Diverse "Privileged" Pyrazole-Derived Molecular Architectures

Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer

Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity

Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors

Frontispiece: Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Novel spiropyrazolone antitumor scaffold with potent activity: Design, synthesis and structure–activity relationship

Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

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