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Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)‑2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction

Organic letters, 2020-05, Vol.22 (9), p.3444-3448

2020

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Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N

Chemical science (Cambridge), 2017-05, Vol.8 (5), p.4093-4099

2017

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Biochemical characterization and substrate profiling of a reversible 2,3-dihydroxybenzoic acid decarboxylase for biocatalytic Kolbe-Schmitt reaction

Enzyme and microbial technology, 2018-06, Vol.113, p.37-43

2018

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Enzymatic synthesis of chiral 2-hydroxy carboxylic acids

Process biochemistry (1991), 2015-05, Vol.50 (5), p.759-770

2015

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A Novel meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum: Overexpression, Characterization, and Potential for d-Amino Acid Synthesis

Applied and Environmental Microbiology, 2012-12, Vol.78 (24), p.8595-8600

2012

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Synthesis of single stereoisomers of 2,2-disubstituted 3-hydroxycyclohexane-1-ones via enzymatic desymmetric reduction of the 1,3-cyclohexanediones

Green synthesis and catalysis, 2021-08, Vol.2 (3), p.320-323

2021

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Engineering the meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum by Site Saturation Mutagenesis for d-Phenylalanine Synthesis

Applied and Environmental Microbiology, 2013-08, Vol.79 (16), p.5078-5081

2013

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Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C–C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols

JACS Au, 2023-11, Vol.3 (11), p.3005-3013

2023

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Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration

Catalysts, 2022-10, Vol.12 (10), p.1133

2022

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Efficient enzymatic synthesis of (S)-1-(3′-bromo-2′-methoxyphenyl)ethanol, the key building block of lusutrombopag

Green synthesis and catalysis, 2023-08, Vol.4 (3), p.268-271

2023

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A New 3-Ketosteroid-Δ1–Dehydrogenase with High Activity and Broad Substrate Scope for Efficient Transformation of Hydrocortisone at High Substrate Concentration

Microorganisms (Basel), 2022-02, Vol.10 (3), p.508

2022

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Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10α-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols

JACS Au, 2024-04, Vol.4 (4), p.1356-1364

2024

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Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines

Applied microbiology and biotechnology, 2014-02, Vol.98 (4), p.1681-1689

2014

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Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids

Journal of molecular catalysis. B, Enzymatic, 2014-02, Vol.100, p.32-39

2014

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Structural and Mutational Studies on the Unusual Substrate Specificity of meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum

Chembiochem : a European journal of chemical biology, 2014-01, Vol.15 (2), p.217-222

2014

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Actinomycetes-derived imine reductases with a preference towards bulky amine substrates

Communications chemistry, 2022-10, Vol.5 (1), p.123-123, Article 123

2022

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Microbial stereospecific reduction of 3-quinuclidinone with newly isolated Nocardia sp. and Rhodococcus erythropolis

Journal of molecular catalysis. B, Enzymatic, 2013-04, Vol.88, p.14-19

2013

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Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

Beilstein journal of organic chemistry, 2015-11, Vol.11 (1), p.2245-2251

2015

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Structural Analysis Reveals the Substrate-Binding Mechanism for the Expanded Substrate Specificity of Mutant meso-Diaminopimelate Dehydrogenase

Chembiochem : a European journal of chemical biology, 2015-04, Vol.16 (6), p.924-929

2015

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Enzymatic hydrogenation of diverse activated alkenes. Identification of two Bacillus old yellow enzymes with broad substrate profiles

Journal of molecular catalysis. B, Enzymatic, 2014-07, Vol.105, p.118-125

2014

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Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals

ChemSusChem, 2022-05, Vol.15 (9), p.e202102399-n/a

2022

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Biocatalytic desymmetrization of 3-substituted glutaronitriles by nitrilases. A convenient chemoenzymatic access to optically active (S)-Pregabalin and (R)-Baclofen

Science China. Chemistry, 2014-08, Vol.57 (8), p.1164-1171

2014

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Chemo-enzymatic synthesis of chiral 3-substituted tetrahydroquinolines by a sequential biocatalytic cascade and Buchwald-Hartwig cyclization

Green chemistry : an international journal and green chemistry resource : GC, 2023-06, Vol.25 (12), p.4667-4673

2023

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N-terminal truncation of a maleate cis–trans isomerase from Rhodococcus jostii RHA1 results in a highly active enzyme for the biocatalytic production of fumaric acid

Journal of molecular catalysis. B, Enzymatic, 2013-09, Vol.93, p.44-50

2013

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Isolation and characterization of a novel Rhodococcus strain with switchable carbonyl reductase and para-acetylphenol hydroxylase activities

Journal of industrial microbiology & biotechnology, 2013, Vol.40 (1), p.11-20

2013

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Structure-Guided Directed Evolution of a Carbonyl Reductase Enables the Stereoselective Synthesis of (2S,3S)‑2,2-Disubstituted-3-hydroxycyclopentanones via Desymmetric Reduction

Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N

Biochemical characterization and substrate profiling of a reversible 2,3-dihydroxybenzoic acid decarboxylase for biocatalytic Kolbe-Schmitt reaction

Enzymatic synthesis of chiral 2-hydroxy carboxylic acids

A Novel meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum: Overexpression, Characterization, and Potential for d-Amino Acid Synthesis

Synthesis of single stereoisomers of 2,2-disubstituted 3-hydroxycyclohexane-1-ones via enzymatic desymmetric reduction of the 1,3-cyclohexanediones

Engineering the meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum by Site Saturation Mutagenesis for d-Phenylalanine Synthesis

Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C–C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols

Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration

Efficient enzymatic synthesis of (S)-1-(3′-bromo-2′-methoxyphenyl)ethanol, the key building block of lusutrombopag

A New 3-Ketosteroid-Δ1–Dehydrogenase with High Activity and Broad Substrate Scope for Efficient Transformation of Hydrocortisone at High Substrate Concentration

Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10α-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols

Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines

Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids

Structural and Mutational Studies on the Unusual Substrate Specificity of meso-Diaminopimelate Dehydrogenase from Symbiobacterium thermophilum

Actinomycetes-derived imine reductases with a preference towards bulky amine substrates

Microbial stereospecific reduction of 3-quinuclidinone with newly isolated Nocardia sp. and Rhodococcus erythropolis

Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

Structural Analysis Reveals the Substrate-Binding Mechanism for the Expanded Substrate Specificity of Mutant meso-Diaminopimelate Dehydrogenase

Enzymatic hydrogenation of diverse activated alkenes. Identification of two Bacillus old yellow enzymes with broad substrate profiles

Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals

Biocatalytic desymmetrization of 3-substituted glutaronitriles by nitrilases. A convenient chemoenzymatic access to optically active (S)-Pregabalin and (R)-Baclofen

Chemo-enzymatic synthesis of chiral 3-substituted tetrahydroquinolines by a sequential biocatalytic cascade and Buchwald-Hartwig cyclization

N-terminal truncation of a maleate cis–trans isomerase from Rhodococcus jostii RHA1 results in a highly active enzyme for the biocatalytic production of fumaric acid

Isolation and characterization of a novel Rhodococcus strain with switchable carbonyl reductase and para-acetylphenol hydroxylase activities

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