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A New Classification of Prodrugs: Regulatory Perspectives

Pharmaceuticals (Basel, Switzerland), 2009-10, Vol.2 (3), p.77-81

Wu, Kuei-Meng

2009

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Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States

Food and chemical toxicology, 2008-08, Vol.46 (8), p.2606-2610

2008

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New therapies from old medicines

Nature biotechnology, 2008-10, Vol.26 (10), p.1077-1083

2008

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Green Tea Extract-Induced Lethal Toxicity in Fasted but Not in Nonfasted Dogs

International journal of toxicology, 2011-02, Vol.30 (1), p.19-20

2011

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Current regulatory perspectives on genotoxicity testing for botanical drug product development in the U.S.A

Regulatory toxicology and pharmacology, 2010-02, Vol.56 (1), p.1-3

2010

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Timing of Carcinogenicity Studies and Predictability of Genotoxicity for Tumorigenicity in Anti-HIV Drug Development

International journal of toxicology, 2012-06, Vol.31 (3), p.211-221

2012

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Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology

Toxicology (Amsterdam), 2007-07, Vol.236 (1), p.1-6

2007

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Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA

American journal of therapeutics, 2006-03, Vol.13 (2), p.141

2006

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Regulatory toxicology perspectives on the development of botanical drug products in the United States

American journal of therapeutics, 2004-05, Vol.11 (3), p.213-217

2004

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Regulatory science: a special update from the United States Food and Drug Administration: Preclinical issues and status of investigation of botanical drug products in the United States

Toxicology letters, 2000-01, Vol.111 (3), p.199-202

2000

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Cardiovascular and respiratory effects of an opioid kappa agonist ethylketazocine and sigma agonist N-allylnormetazocine in acutely decerebrated dogs

Pharmacology, biochemistry and behavior, 1989-10, Vol.34 (2), p.405-411

1989

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Effects of Ritanserin on Transmembrane Action Potentials in Canine Purkinje Fibers

Proceedings of the Society for Experimental Biology and Medicine, 1992-01, Vol.199 (1), p.88-92

1992

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A dual model for cardiac arrhythmias: coexistence of re‐entry and abnormal automaticity and effects of antiarrhythmic agents

British journal of pharmacology, 1989-09, Vol.98 (1), p.268-274

1989

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Pharmacological characterisation of a re-entry model for atrial tachycardia in conscious dogs

Cardiovascular research, 1989-05, Vol.23 (5), p.400-409

1989

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Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis

The Journal of infectious diseases, 1986-01, Vol.153 (1), p.71

1986

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Botanical Drug Development: Waiver of Preclinical Pharm/Tox Studies and Importance of Initial Cinical Trial Design

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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Botanical Drug Product Development in the U.S.A.: Importance of Genotoxicity Testing

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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New therapies from old medicines: although new botanical drugs pose many challenges for both industry and the FDA, approval of the first botanical prescription drug shows they can be successfully met

Nature biotechnology, 2008-10, Vol.26 (10), p.1077

2008

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Monophasic Action Potentials During Reentrant Atrial Flutter in the Dog: Effects of Clofilium and Acetylcholine

Journal of cardiovascular pharmacology, 1989-06, Vol.13 (6), p.908-914

1989

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Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits

Journal of applied physiology (1985), 1985-12, Vol.59 (6), p.1978

1985

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A dual electrophysiologic test for atrial antireentry and ventricular antifibrillatory studies: Effects of bethanidine, procainamide, and WY-48986

Journal of pharmacological methods, 1990-04, Vol.23 (2), p.87-95

1990

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Regulatory science: a special update from the United States Food and Drug Administration

Toxicology letters, 2000-01, Vol.111 (3), p.199-202

2000

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Effect of procainamide and N-acetylprocainamide on atrial flutter; studies in vivo and in vitro

Circulation (New York, N.Y.), 1987-12, Vol.76 (6), p.1397-1408

1987

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A dual electrophysiologic test for atrial antireentry and ventricular antifibrillatory studies

Journal of pharmacological methods, 1990-04, Vol.23 (2), p.87-95

1990

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THE EFFECTS OF FENTANYL, ETHYLKETAZOCINE, N-ALLYLNORMETAZOCINE AND NALOXONE IN ACUTELY DECEREBRATED DOGS

WU, KUEI-MENG

1983

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A New Classification of Prodrugs: Regulatory Perspectives

Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States

New therapies from old medicines

Green Tea Extract-Induced Lethal Toxicity in Fasted but Not in Nonfasted Dogs

Current regulatory perspectives on genotoxicity testing for botanical drug product development in the U.S.A

Timing of Carcinogenicity Studies and Predictability of Genotoxicity for Tumorigenicity in Anti-HIV Drug Development

Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology

Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA

Regulatory toxicology perspectives on the development of botanical drug products in the United States

Regulatory science: a special update from the United States Food and Drug Administration: Preclinical issues and status of investigation of botanical drug products in the United States

Cardiovascular and respiratory effects of an opioid kappa agonist ethylketazocine and sigma agonist N-allylnormetazocine in acutely decerebrated dogs

Effects of Ritanserin on Transmembrane Action Potentials in Canine Purkinje Fibers

A dual model for cardiac arrhythmias: coexistence of re‐entry and abnormal automaticity and effects of antiarrhythmic agents

Pharmacological characterisation of a re-entry model for atrial tachycardia in conscious dogs

Streptococcus pneumoniae-induced alterations in levels of circulating thromboxane and prostacyclin: dissociation from granulocytopenia, thrombocytopenia, and pulmonary leukostasis

Botanical Drug Development: Waiver of Preclinical Pharm/Tox Studies and Importance of Initial Cinical Trial Design

Botanical Drug Product Development in the U.S.A.: Importance of Genotoxicity Testing

New therapies from old medicines: although new botanical drugs pose many challenges for both industry and the FDA, approval of the first botanical prescription drug shows they can be successfully met

Monophasic Action Potentials During Reentrant Atrial Flutter in the Dog: Effects of Clofilium and Acetylcholine

Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits

A dual electrophysiologic test for atrial antireentry and ventricular antifibrillatory studies: Effects of bethanidine, procainamide, and WY-48986

Regulatory science: a special update from the United States Food and Drug Administration

Effect of procainamide and N-acetylprocainamide on atrial flutter; studies in vivo and in vitro

A dual electrophysiologic test for atrial antireentry and ventricular antifibrillatory studies

THE EFFECTS OF FENTANYL, ETHYLKETAZOCINE, N-ALLYLNORMETAZOCINE AND NALOXONE IN ACUTELY DECEREBRATED DOGS

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