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The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins

Molecular cell, 2011-06, Vol.42 (5), p.662-672

2011

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Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with the Inhibitor Ribavirin Monophosphate Reveals a Catalysis-dependent Ion-binding Site

The Journal of biological chemistry, 2002-12, Vol.277 (52), p.50654-50659

2002

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Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

Molecular cancer therapeutics, 2007-03, Vol.6 (3), p.935-944

2007

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Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design

Journal of antimicrobial chemotherapy, 2003-10, Vol.52 (4), p.543-546

2003

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Phosphorylation of Ribavirin and Viramidine by Adenosine Kinase and Cytosolic 5′-Nucleotidase II: Implications for Ribavirin Metabolism in Erythrocytes

Antimicrobial Agents and Chemotherapy, 2005-06, Vol.49 (6), p.2164-2171

2005

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Current state and challenges in respiratory syncytial virus drug discovery and development

Antiviral research, 2024-01, Vol.221, p.105791-105791, Article 105791

2024

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Selection of 3′-Template Bases and Initiating Nucleotides by Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase

Journal of Virology, 2002-07, Vol.76 (14), p.7030-7039

2002

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Canonical 3′-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase

Antiviral research, 2003-05, Vol.58 (3), p.243-251

2003

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Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions

Antimicrobial Agents and Chemotherapy, 2003-01, Vol.47 (1), p.426-431

2003

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Design, Synthesis, and Antiviral Activity of Adenosine 5‘-Phosphonate Analogues as Chain Terminators against Hepatitis C Virus

Journal of medicinal chemistry, 2005-04, Vol.48 (8), p.2867-2875

2005

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Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

Antimicrobial Agents and Chemotherapy, 2004-10, Vol.48 (10), p.4006-4008

2004

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Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6003-6014

2019

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Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency

The Journal of infection, 2024-02, Vol.88 (2), p.211-214

2024

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Functional Properties of a Monoclonal Antibody Inhibiting the Hepatitis C Virus RNA-dependent RNA Polymerase

The Journal of biological chemistry, 2002-01, Vol.277 (1), p.593-601

2002

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Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10228-10241

2018

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Internally Located Signal Peptides Direct Hepatitis C Virus Polyprotein Processing in the ER Membrane

IUBMB life, 2001-01, Vol.51 (1), p.19-23

Wu, Jim Zhen

2001

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Discovery and Pre-Clinical Characterization of Third-Generation 4‑H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3352-3371

2017

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A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein

hLife, 2023-11, Vol.1 (1), p.12-25

2023

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Potential drug interventions for diabetic retinopathy

Drug discovery today, 2013-12, Vol.18 (23-24), p.1334-1341

2013

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Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma

Molecular cancer therapeutics, 2013-08, Vol.12 (8), p.1393-1401

2013

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Identification of novel, selective and potent Chk2 inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.172-175

2007

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Conversion of Viramidine to Ribavirin in Vivo by Adenosine Deaminase and its Inhibition by 2′-Deoxycoformycin

Antiviral chemistry & chemotherapy, 2006, Vol.17 (1), p.33-39

2006

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Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase

Mini reviews in medicinal chemistry, 2005-12, Vol.5 (12), p.1103-1112

2005

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Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10228-10241

2018

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Internally Located Signal Peptides Direct Hepatitis C Virus Polyprotein Processing in the ER Membrane

IUBMB life, 2001-01, Vol.51 (1), p.19-23

Wu, Jim Zhen

2001

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The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins

Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with the Inhibitor Ribavirin Monophosphate Reveals a Catalysis-dependent Ion-binding Site

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design

Phosphorylation of Ribavirin and Viramidine by Adenosine Kinase and Cytosolic 5′-Nucleotidase II: Implications for Ribavirin Metabolism in Erythrocytes

Current state and challenges in respiratory syncytial virus drug discovery and development

Selection of 3′-Template Bases and Initiating Nucleotides by Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase

Canonical 3′-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase

Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions

Design, Synthesis, and Antiviral Activity of Adenosine 5‘-Phosphonate Analogues as Chain Terminators against Hepatitis C Virus

Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency

Functional Properties of a Monoclonal Antibody Inhibiting the Hepatitis C Virus RNA-dependent RNA Polymerase

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Internally Located Signal Peptides Direct Hepatitis C Virus Polyprotein Processing in the ER Membrane

Discovery and Pre-Clinical Characterization of Third-Generation 4‑H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors

A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein

Potential drug interventions for diabetic retinopathy

Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma

Identification of novel, selective and potent Chk2 inhibitors

Conversion of Viramidine to Ribavirin in Vivo by Adenosine Deaminase and its Inhibition by 2′-Deoxycoformycin

Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Internally Located Signal Peptides Direct Hepatitis C Virus Polyprotein Processing in the ER Membrane

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