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Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line

Toxicological sciences, 2012-06, Vol.127 (2), p.403-411

2012

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Anticancer Potential of Sutherlandia frutescens and Xysmalobium undulatum in LS180 Colorectal Cancer Mini-Tumors

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.605

2021

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From 2D to 3D--a New Dimension for Modelling the Effect of Natural Products on Human Tissue

Current pharmaceutical design, 2015-01, Vol.21 (38), p.5605-5616

2015

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A Novel NCI-H69AR Drug-Resistant Small-Cell Lung Cancer Mini-Tumor Model for Anti-Cancer Treatment Screening

Cells (Basel, Switzerland), 2023-07, Vol.12 (15), p.1980

2023

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Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors

Bioengineering (Basel), 2018-03, Vol.5 (1), p.22

2018

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The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments

PloS one, 2014-09, Vol.9 (9), p.e106973-e106973

2014

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Hepatocellular carcinoma (HepG2/C3A) cell-based 3D model for genotoxicity testing of chemicals

The Science of the total environment, 2021-02, Vol.755 (Pt 2), p.143255, Article 143255

2021

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A novel NCI‐H69V small cell lung cancer functional mini‐tumor model for future treatment screening applications

Biotechnology progress, 2022-07, Vol.38 (4), p.e3253-n/a

2022

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In vitro evaluation of the anti-melanoma effects (A375 cell line) of the gel and whole leaf extracts from selected aloe species

Journal of herbal medicine, 2022-02, Vol.31, p.100539, Article 100539

2022

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Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes

Molecular & cellular proteomics, 2011-01, Vol.10 (1), p.M110.000299-M110.000299, Article M110.000299

2011

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Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns[S]

Molecular & cellular proteomics, 2015-12, Vol.14 (12), p.3142-3153

2015

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Microgravity spheroids as a reliable, long-term tool for predictive toxicology

Toxicology letters, 2013-08, Vol.221, p.S153-S153

2013

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Response to and recovery from treatment in human liver-mimetic clinostat spheroids: a model for assessing repeated-dose drug toxicity

Toxicology research (Cambridge), 2020-07, Vol.9 (4), p.379-389

2020

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Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2273, p.17

2021

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Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

ACS medicinal chemistry letters, 2020-05, Vol.11 (5), p.1014-1021

2020

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A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model

Journal of ethnopharmacology, 2019-07, Vol.239, p.111897, Article 111897

2019

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Cell-free DNA in a three-dimensional spheroid cell culture model: A preliminary study

The international journal of biochemistry & cell biology, 2017-08, Vol.89, p.182-192

2017

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The role of reversible cysteine oxidations in intracellular signaling – mass spectrometry based study of acetaminophen driven redox imbalance

Free radical biology & medicine, 2016-07, Vol.96, p.S53

2016

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P-49 - The role of reversible cysteine oxidations in intracellular signaling – mass spectrometry based study of acetaminophen driven redox imbalance

Free radical biology & medicine, 2016-07, Vol.96, p.S53-S53

2016

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Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective

Toxicology mechanisms and methods, 2018-06, Vol.28 (5), p.1-385

2018

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After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver

Toxicology research (Cambridge), 2013-01, Vol.2 (2), p.123-135

2013

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Heteromer score-using internal standards to assess the quality of proteomic data

Proteomics (Weinheim), 2014-05, Vol.14 (9), p.1042-1047

2014

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Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures

Toxicology mechanisms and methods, 2018-11, Vol.28 (9), p.641-652

2018

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Acetaminophen-induced S -nitrosylation and S -sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids

Toxicology research (Cambridge), 2016-05, Vol.5 (3), p.905-920

2016

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Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes

The Journal of biological chemistry, 2003-03, Vol.278 (12), p.10436-10442

2003

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Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line

Anticancer Potential of Sutherlandia frutescens and Xysmalobium undulatum in LS180 Colorectal Cancer Mini-Tumors

From 2D to 3D--a New Dimension for Modelling the Effect of Natural Products on Human Tissue

A Novel NCI-H69AR Drug-Resistant Small-Cell Lung Cancer Mini-Tumor Model for Anti-Cancer Treatment Screening

Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors

The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments

Hepatocellular carcinoma (HepG2/C3A) cell-based 3D model for genotoxicity testing of chemicals

A novel NCI‐H69V small cell lung cancer functional mini‐tumor model for future treatment screening applications

In vitro evaluation of the anti-melanoma effects (A375 cell line) of the gel and whole leaf extracts from selected aloe species

Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes

Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns[S]

Microgravity spheroids as a reliable, long-term tool for predictive toxicology

Response to and recovery from treatment in human liver-mimetic clinostat spheroids: a model for assessing repeated-dose drug toxicity

Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids

Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model

Cell-free DNA in a three-dimensional spheroid cell culture model: A preliminary study

The role of reversible cysteine oxidations in intracellular signaling – mass spectrometry based study of acetaminophen driven redox imbalance

P-49 - The role of reversible cysteine oxidations in intracellular signaling – mass spectrometry based study of acetaminophen driven redox imbalance

Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective

After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver

Heteromer score-using internal standards to assess the quality of proteomic data

Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures

Acetaminophen-induced S -nitrosylation and S -sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids

Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes

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