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LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

PloS one, 2013-06, Vol.8 (6), p.e65763

2013

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319

PloS one, 2013-03, Vol.8 (3), p.e58575

2013

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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

mAbs, 2015-05, Vol.7 (3), p.483-493

2015

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Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

Blood, 2009-05, Vol.113 (21), p.5277-5286

2009

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The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21

Endocrinology (Philadelphia), 2007-02, Vol.148 (2), p.774-781

2007

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

mAbs, 2015-11, Vol.7 (6), p.1084-1093

2015

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Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model

The Journal of pharmacology and experimental therapeutics, 2015-09, Vol.354 (3), p.350-357

2015

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Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys

mAbs, 2016-07, Vol.8 (5), p.969-982

2016

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Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry

Blood, 2007-08, Vol.110 (3), p.1048-1054

2007

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In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS

Analytical chemistry (Washington), 2005-03, Vol.77 (5), p.1432-1439

2005

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Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]

Journal of lipid research, 2015-11, Vol.56 (11), p.2124-2132

2015

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FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys

Drug metabolism and disposition, 2012-08, Vol.40 (8), p.1545-1555

2012

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Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587

Oncotarget, 2017-11, Vol.8 (55), p.94619-94634

2017

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Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting

Molecular cancer therapeutics, 2015-07, Vol.14 (7), p.1661-1670

2015

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Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells

Molecular biology of the cell, 2008-12, Vol.19 (12), p.5490-5505

2008

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Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.86

2007

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Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys

mAbs, 2012-03, Vol.4 (2), p.267-273

2012

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Peripheral and central nervous system distribution of the CGRP neutralizing antibody [125I] galcanezumab in male rats

Cephalalgia, 2019-09, Vol.39 (10), p.1241-1248

2019

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A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets

The Journal of biological chemistry, 2016-05, Vol.291 (21), p.11337-11347

2016

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Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency

British journal of haematology, 2009-03, Vol.144 (5), p.789-793

2009

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Application of FcRn binding assays to guide mAb development

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1867-1872

2014

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Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

Journal of inflammation research, 2016-04, Vol.9 (Issue 1), p.39-50

2016

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FGF-21 as a novel metabolic regulator

The Journal of clinical investigation, 2005-06, Vol.115 (6), p.1627-1635

2005

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Monoclonal Antibody Clearance: IMPACT OF MODULATING THE INTERACTION OF IgG WITH THE NEONATAL Fc RECEPTOR

The Journal of biological chemistry, 2007-01, Vol.282 (3), p.1709-1717

2007

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Correlation between antidrug antibodies, pre-existing antidrug reactivity, and immunogenetics (MHC class II alleles) in cynomolgus macaque

Immunogenetics (New York), 2019-11, Vol.71 (10), p.605-615

2019

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LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model

Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry

In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]

FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys

Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587

Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting

Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys

Peripheral and central nervous system distribution of the CGRP neutralizing antibody [125I] galcanezumab in male rats

A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets

Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency

Application of FcRn binding assays to guide mAb development

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

FGF-21 as a novel metabolic regulator

Monoclonal Antibody Clearance: IMPACT OF MODULATING THE INTERACTION OF IgG WITH THE NEONATAL Fc RECEPTOR

Correlation between antidrug antibodies, pre-existing antidrug reactivity, and immunogenetics (MHC class II alleles) in cynomolgus macaque

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