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Codon Modification and PAMPs in Clinical AAV Vectors: The Tortoise or the Hare?

Molecular therapy, 2020-03, Vol.28 (3), p.701-703

Wright, J. Fraser

2020

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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

The New England journal of medicine, 2013-04, Vol.368 (16), p.1509-1518

2013

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Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll

Molecular therapy, 2020-08, Vol.28 (8), p.1756-1758

Wright, J. Fraser

2020

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Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes

Frontiers in immunology, 2021-05, Vol.12, p.675897-675897

2021

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Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery

Molecular therapy, 2018-09, Vol.26 (9), p.2282-2294

2018

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Assessing the potential for AAV vector genotoxicity in a murine model

Blood, 2011-03, Vol.117 (12), p.3311-3319

2011

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Transient transfection methods for clinical adeno-associated viral vector production

Human gene therapy, 2009-07, Vol.20 (7), p.698-706

Wright, J Fraser

2009

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Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease

Science translational medicine, 2021-06, Vol.13 (598)

2021

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AAV vector production: Troublesome host innate responses in another setting

Molecular therapy. Methods & clinical development, 2023-03, Vol.28, p.412-413

Wright, J. Fraser

2023

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Product-Related Impurities in Clinical-Grade Recombinant AAV Vectors: Characterization and Risk Assessment

Biomedicines, 2014-03, Vol.2 (1), p.80-97

Wright, J Fraser

2014

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Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2

Ophthalmology (Rochester, Minn.), 2013-06, Vol.120 (6), p.1283-1291

2013

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Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

The New England journal of medicine, 2008-05, Vol.358 (21), p.2240-2248

2008

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Quality Control Testing, Characterization and Critical Quality Attributes of Adeno‐Associated Virus Vectors Used for Human Gene Therapy

Biotechnology journal, 2021-01, Vol.16 (1), p.e2000022-n/a

Wright, J. Fraser

2021

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Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses

Molecular therapy, 2013-01, Vol.21 (1), p.158-166

2013

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AAV vector manufacturing process design and scalability - Bending the trajectory to address vector-associated immunotoxicities

Molecular therapy, 2022-06, Vol.30 (6), p.2119-2121

Wright, J. Fraser

2022

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Re-administration of AAV vectors by masking with host albumin: A Goldilocks hypothesis

Molecular therapy, 2023-07, Vol.31 (7), p.1870-1873

Wright, J. Fraser

2023

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Translational nanomedicine: status assessment and opportunities

Nanomedicine, 2009-09, Vol.5 (3), p.251-273

2009

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Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates

Molecular therapy. Methods & clinical development, 2020-06, Vol.17, p.1129-1138

2020

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Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver

Blood, 2007-10, Vol.110 (7), p.2334-2341

2007

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Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

Molecular therapy, 2012-07, Vol.20 (7), p.1410-1416

2012

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Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

PloS one, 2015-06, Vol.10 (6), p.e0130612-e0130612

2015

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Systemic errors in quantitative polymerase chain reaction titration of self-complementary adeno-associated viral vectors and improved alternative methods

Human gene therapy. Part B. Methods, 2012-02, Vol.23 (1), p.1-7

2012

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AAV Empty Capsids: For Better or for Worse?

Molecular therapy, 2014-01, Vol.22 (1), p.1-2

Wright, J Fraser

2014

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Codon Modification and PAMPs in Clinical AAV Vectors: The Tortoise or the Hare?

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll

Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes

Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

Assessing the potential for AAV vector genotoxicity in a murine model

Transient transfection methods for clinical adeno-associated viral vector production

Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease

AAV vector production: Troublesome host innate responses in another setting

Product-Related Impurities in Clinical-Grade Recombinant AAV Vectors: Characterization and Risk Assessment

Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

Quality Control Testing, Characterization and Critical Quality Attributes of Adeno‐Associated Virus Vectors Used for Human Gene Therapy

Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses

AAV vector manufacturing process design and scalability - Bending the trajectory to address vector-associated immunotoxicities

Re-administration of AAV vectors by masking with host albumin: A Goldilocks hypothesis

Translational nanomedicine: status assessment and opportunities

Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material

Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates

Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

Systemic errors in quantitative polymerase chain reaction titration of self-complementary adeno-associated viral vectors and improved alternative methods

AAV Empty Capsids: For Better or for Worse?

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