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Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (19), p.5207-5211

2006

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Small-molecule melanin-concentrating hormone-1 receptor antagonists require brain penetration for inhibition of food intake and reduction in body weight

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.206-213

2008

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MCH-R1 antagonists: what is keeping most research programs away from the clinic?

Drug discovery today, 2007-11, Vol.12 (21), p.972-979

2007

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Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4668-4673

2006

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Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4745-4761

2006

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Design, synthesis, and evaluation of proline based melanocortin receptor ligands

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2819-2823

2005

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Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.6055-6066

2008

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Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.814-818

2007

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Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (3), p.1311-1322

2007

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Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.657-661

2007

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Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4291-4294

2005

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Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5434-5438

2005

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Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4728-4732

2006

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Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1721-1725

2006

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Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5445-5450

2006

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The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: A novel class of potent MCH-R1 antagonists

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.2092-2105

2007

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Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists—Increasing selectivity over hERG

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.819-822

2007

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The Synthesis and Human FP Receptor Binding Affinity of 13, 14-Dihydro Prostaglandin F1α Sulfonamides : Potential Treatments for Osteoporosis

Chemical and Pharmaceutical Bulletin, 2000/09/01, Vol.48(9), pp.1332-1337

2000

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Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4233-4236

2006

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Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4322-4326

2005

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Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4157-4169

2001

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Patent developments in anabolic agents for treatment of bone diseases

Expert opinion on therapeutic patents, 2003-08, Vol.13 (8), p.1141-1156

2003

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An Efficient Synthesis of 3-Hetero-13,14-dihydro Prostaglandin F1α Analogues

Organic letters, 2001-03, Vol.3 (5), p.791-794

2001

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Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

Bioorganic & medicinal chemistry letters, 2000-07, Vol.10 (14), p.1519-1522

2000

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Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4307-4307

2001

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Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents

Small-molecule melanin-concentrating hormone-1 receptor antagonists require brain penetration for inhibition of food intake and reduction in body weight

MCH-R1 antagonists: what is keeping most research programs away from the clinic?

Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists

Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach

Design, synthesis, and evaluation of proline based melanocortin receptor ligands

Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG

Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors

Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis

Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors

Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity

The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: A novel class of potent MCH-R1 antagonists

Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists—Increasing selectivity over hERG

The Synthesis and Human FP Receptor Binding Affinity of 13, 14-Dihydro Prostaglandin F1α Sulfonamides : Potential Treatments for Osteoporosis

Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors

Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme

Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis

Patent developments in anabolic agents for treatment of bone diseases

An Efficient Synthesis of 3-Hetero-13,14-dihydro Prostaglandin F1α Analogues

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis

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