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Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.16974-17003

2021

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

EMBO reports, 2011-05, Vol.12 (5), p.463-469

2011

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Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1810-1818

2010

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Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily‐Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

Chemistry, an Asian journal, 2018-10, Vol.13 (19), p.2854-2867

2018

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Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Nanoscale, 2020-09, Vol.12 (35), p.1822-183

2020

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A Cost-Effectiveness Analysis of Wittmann Patch-Assisted Abdominal Closure Compared to Planned Ventral Hernia in Management of the Open Abdomen

The American surgeon, 2024-06, Vol.90 (6), p.1140-1147

2024

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A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity

Chemical communications (Cambridge, England), 2016-01, Vol.52 (36), p.6181-6184

2016

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Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Angewandte Chemie International Edition, 2012-02, Vol.51 (7), p.1631-1634

International ed. in English, 2012

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Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors

Angewandte Chemie International Edition, 2012-07, Vol.51 (27), p.6672-6675

2012

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Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2173-2184

2012

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Observations on the Deprotection of Pinanediol and Pinacol Boronate Esters via Fluorinated Intermediates

Journal of organic chemistry, 2010-01, Vol.75 (2), p.468-471

2010

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Poly(ADP-ribose)polymerase inhibition - where now?

Current medicinal chemistry, 2005-01, Vol.12 (20), p.2373-2392

2005

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Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

ChemMedChem, 2011-05, Vol.6 (5), p.759-764

2011

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A safe lithium mimetic for bipolar disorder

Nature communications, 2013-01, Vol.4 (1), p.1332-1332, Article 1332

2013

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5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2049-2059

2011

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Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors

Journal of medicinal chemistry, 2009-10, Vol.52 (19), p.6097-6106

2009

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Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)

ACS chemical biology, 2011-09, Vol.6 (9), p.943-951

2011

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Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

International journal of nanomedicine, 2017-01, Vol.12, p.2759-2767

2017

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N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

Scientific reports, 2016-05, Vol.6 (1), p.25677, Article 25677

2016

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Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis

International journal of pharmaceutics, 2024-04, Vol.654, p.123960-123960, Article 123960

2024

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Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity

Biochemical and biophysical research communications, 2016-10, Vol.479 (3), p.476-481

2016

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A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6 -methyladenosine demethylase activity in cells

Chemical science (Cambridge), 2018-09, Vol.9 (36), p.7174-7185

2018

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A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6 -methyladenosine demethylase FTO

Chemical science (Cambridge), 2015-01, Vol.6 (1), p.112-122

2015

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Microsurgical Resection of a Left Eloquent Arteriovenous Malformation Presenting With Papilledema: 3-Dimensional Operative Video

Operative neurosurgery (Hagerstown, Md.), 2024-09

2024

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Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily‐Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

A Cost-Effectiveness Analysis of Wittmann Patch-Assisted Abdominal Closure Compared to Planned Ventral Hernia in Management of the Open Abdomen

A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors

Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Observations on the Deprotection of Pinanediol and Pinacol Boronate Esters via Fluorinated Intermediates

Poly(ADP-ribose)polymerase inhibition - where now?

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

A safe lithium mimetic for bipolar disorder

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors

Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6 -methyladenosine demethylase activity in cells

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6 -methyladenosine demethylase FTO

Microsurgical Resection of a Left Eloquent Arteriovenous Malformation Presenting With Papilledema: 3-Dimensional Operative Video

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