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Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.639-646

2004

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Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

Chemical research in toxicology, 1998-04, Vol.11 (4), p.252-259

1998

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The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

British journal of clinical pharmacology, 1994-07, Vol.38 (1), p.15-22

1994

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Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

The Journal of pharmacology and experimental therapeutics, 1999-02, Vol.288 (2), p.791

1999

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Metabolism and excretion of atorvastatin in rats and dogs

Drug metabolism and disposition, 1999-08, Vol.27 (8), p.916

1999

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Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

Biochemical pharmacology, 2001-07, Vol.62 (2), p.191-198

2001

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Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase

Drug metabolism and disposition, 2004-04, Vol.32 (4), p.442-446

2004

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An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro: Studies with human and rat liver microsomes

Biochemical pharmacology, 1993-07, Vol.46 (1), p.13-20

1993

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Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference

Drug metabolism and disposition, 1993-09, Vol.21 (5), p.874

1993

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Characterization of the induction of rat microsomal cytochrome P450 by tacrine

Biochemical pharmacology, 1997-08, Vol.54 (3), p.425-427

1997

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The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity

Hepatology (Baltimore, Md.), 1996-06, Vol.23 (6), p.1429-1435

1996

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Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease

British journal of clinical pharmacology, 1998-09, Vol.46 (3), p.221-228

1998

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Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons

Drug metabolism and disposition, 1997-05, Vol.25 (5), p.590

1997

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The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity

Hepatology (Baltimore, Md.), 1996-06, Vol.23 (6), p.1429-1435

1996

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Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue

Drug metabolism and disposition, 1996-06, Vol.24 (6), p.628

1996

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Species variation in the bioactivation of tacrine by hepatic microsomes

Xenobiotica, 1995, Vol.25 (1), p.103-116

1995

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Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Journal of medicinal chemistry, 1996-07, Vol.39 (15), p.3014-3018

1996

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Stereoselective hydroxylation of tacrine in rats and humans

Drug metabolism and disposition, 1994-09, Vol.22 (5), p.719

1994

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Oxicams: Metabolic Disposition in Man and Animals

Drug metabolism reviews, 1989, Vol.21 (2), p.255-276

1989

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Characterization of nonlinear elimination of the xanthine-related drug ethimizol in 3-methylcholanthrene-induced rat liver by the "parallel-tube" model

Drug metabolism and disposition, 1993-05, Vol.21 (3), p.547

1993

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The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations

Xenobiotica, 1996-09, Vol.26 (9), p.935-946

1996

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Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations

Xenobiotica, 1987, Vol.17 (7), p.839-847

1987

Volltextzugriff (PDF)

Metabolic disposition of tacrine in primary suspensions of rat hepatocyte and in single-pass perfused liver: in vitro/in vivo comparisons

Xenobiotica, 1994, Vol.24 (11), p.1107-1117

1994

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Biodisposition studies with the acyl-coenzyme A: cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CI-976

Drug metabolism and disposition, 1993-11, Vol.21 (6), p.1112

1993

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Tacrine hepatotoxicity— The use of caffeine to identify potential susceptibility factors

Hepatology (Baltimore, Md.), 1994-04, Vol.19 (4), p.I63-I63

1994

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Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved

Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

Metabolism and excretion of atorvastatin in rats and dogs

Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro: Studies with human and rat liver microsomes

Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference

Characterization of the induction of rat microsomal cytochrome P450 by tacrine

The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity

Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease

Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons

The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity

Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue

Species variation in the bioactivation of tacrine by hepatic microsomes

Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Stereoselective hydroxylation of tacrine in rats and humans

Oxicams: Metabolic Disposition in Man and Animals

Characterization of nonlinear elimination of the xanthine-related drug ethimizol in 3-methylcholanthrene-induced rat liver by the "parallel-tube" model

The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations

Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations

Metabolic disposition of tacrine in primary suspensions of rat hepatocyte and in single-pass perfused liver: in vitro/in vivo comparisons

Biodisposition studies with the acyl-coenzyme A: cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CI-976

Tacrine hepatotoxicity— The use of caffeine to identify potential susceptibility factors

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