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Metabolism and excretion of atorvastatin in rats and dogs

Drug metabolism and disposition, 1999-08, Vol.27 (8), p.916

1999

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The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

British journal of clinical pharmacology, 1994-07, Vol.38 (1), p.15-22

1994

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Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference

Drug metabolism and disposition, 1993-09, Vol.21 (5), p.874

1993

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Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

Chemical research in toxicology, 1998-04, Vol.11 (4), p.252-259

1998

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Species variation in the bioactivation of tacrine by hepatic microsomes

Xenobiotica, 1995, Vol.25 (1), p.103-116

1995

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Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue

Drug metabolism and disposition, 1996-06, Vol.24 (6), p.628

1996

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Stereoselective hydroxylation of tacrine in rats and humans

Drug metabolism and disposition, 1994-09, Vol.22 (5), p.719

1994

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Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

The Journal of pharmacology and experimental therapeutics, 1999-02, Vol.288 (2), p.791

1999

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Characterization of the induction of rat microsomal cytochrome P450 by tacrine

Biochemical pharmacology, 1997-08, Vol.54 (3), p.425-427

1997

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Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons

Drug metabolism and disposition, 1997-05, Vol.25 (5), p.590

1997

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The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity

Hepatology (Baltimore, Md.), 1996-06, Vol.23 (6), p.1429-1435

1996

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The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations

Xenobiotica, 1996-09, Vol.26 (9), p.935-946

1996

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Characterization of nonlinear elimination of the xanthine-related drug ethimizol in 3-methylcholanthrene-induced rat liver by the "parallel-tube" model

Drug metabolism and disposition, 1993-05, Vol.21 (3), p.547

1993

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Biodisposition studies with the acyl-coenzyme A: cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CI-976

Drug metabolism and disposition, 1993-11, Vol.21 (6), p.1112

1993

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Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Journal of medicinal chemistry, 1996-07, Vol.39 (15), p.3014-3018

1996

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Metabolism and excretion studies in mouse after single and multiple oral doses of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.755

1998

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Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

Biochemical pharmacology, 2001-07, Vol.62 (2), p.191-198

2001

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Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog

Drug metabolism and disposition, 1990-11, Vol.18 (6), p.980

1990

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Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway

Drug metabolism and disposition, 1991-05, Vol.19 (3), p.696

1991

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Oxicams: Metabolic Disposition in Man and Animals

Drug metabolism reviews, 1989, Vol.21 (2), p.255-276

1989

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An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro: Studies with human and rat liver microsomes

Biochemical pharmacology, 1993-07, Vol.46 (1), p.13-20

1993

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Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations

Xenobiotica, 1987, Vol.17 (7), p.839-847

1987

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Metabolic disposition of tacrine in primary suspensions of rat hepatocyte and in single-pass perfused liver: in vitro/in vivo comparisons

Xenobiotica, 1994, Vol.24 (11), p.1107-1117

1994

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In vivo metabolism of isoxicam in rats, dogs, and monkeys

Drug metabolism and disposition, 1989-11, Vol.17 (6), p.662

1989

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Preparation of diastereomeric β-d-glucuronides of the bronchodilator procaterol using immobilized rabbit liver microsomal enzymes

European journal of drug metabolism and pharmacokinetics, 1989-04, Vol.14 (2), p.111-116

1989

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Metabolism and excretion of atorvastatin in rats and dogs

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference

Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

Species variation in the bioactivation of tacrine by hepatic microsomes

Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue

Stereoselective hydroxylation of tacrine in rats and humans

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

Characterization of the induction of rat microsomal cytochrome P450 by tacrine

Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons

The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity

The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations

Characterization of nonlinear elimination of the xanthine-related drug ethimizol in 3-methylcholanthrene-induced rat liver by the "parallel-tube" model

Biodisposition studies with the acyl-coenzyme A: cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CI-976

Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Metabolism and excretion studies in mouse after single and multiple oral doses of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin

Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog

Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway

Oxicams: Metabolic Disposition in Man and Animals

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro: Studies with human and rat liver microsomes

Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations

Metabolic disposition of tacrine in primary suspensions of rat hepatocyte and in single-pass perfused liver: in vitro/in vivo comparisons

In vivo metabolism of isoxicam in rats, dogs, and monkeys

Preparation of diastereomeric β-d-glucuronides of the bronchodilator procaterol using immobilized rabbit liver microsomal enzymes

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