UB Paderborn / Katalog / Suche / in CDI

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2293-2296

2007

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A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera

Journal of molecular biology, 2007-03, Vol.367 (3), p.882-894

2007

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Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model

Organic & biomolecular chemistry, 2013-04, Vol.11 (15), p.2514-2533

2013

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A Total Synthesis of Estrone Based on a Novel Cascade of Radical Cyclizations

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.12024-12029

2004

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Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.414-426

2005

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Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Bioorganic & medicinal chemistry, 2006-02, Vol.14 (4), p.1255-1273

2006

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AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Clinical cancer research, 2012-07, Vol.18 (14), p.3912-3923

2012

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AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth

Molecular cancer therapeutics, 2010-05, Vol.9 (5), p.1100-1110

2010

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Fragment-based discovery of inhibitors of protein kinase B

Current topics in medicinal chemistry, 2009-12, Vol.9 (18), p.1705

2009

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Towards the enantioselective synthesis of (−)-euonyminol - preparation of a fully functionalised lower-rim modelElectronic supplementary information (ESI) available: Crystallographic analysis for compounds 6, 17, 18c, 28a and 31 including CIF files and NMR spectra for all new compounds. CCDC 905361-905365. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3ob27187k

2013-03

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Abstract 4748: Discovery of JNJ-42756493, a potent fibroblast growth factor receptor (FGFR) inhibitor using a fragment based approach

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4748-4748

2014

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Abstract 928: The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.928-928

2012

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Enantioselective Desymmetrization of meso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores AE=Asymmetric epoxidation. Grateful acknowledgement is made to the EPSRC for a QUOTA studentship (S.J.W.) and to Pfizer (Drs. Alan R. Brown and John P. Mathias) for financial support of this work

Angewandte Chemie International Edition, 2001-02, Vol.40 (4), p.769-771

2001

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Enantioselective Desymmetrization of meso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores

Angewandte Chemie (International ed.), 2001-02, Vol.40 (4), p.769-771

2001

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Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.414-426

2005

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Chapter 2. Synthetic methods . Part (v) Protecting groups

Annual reports on the progress of chemistry. Section B. Organic chemistry, 1998, Vol.94, p.77

1998

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Synthetic approaches to celastraceae sesquiterpenoids

Woodhead, Steven J

1998

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Enantioselective Desymmetrization of meso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores

Angewandte Chemie, 2001-02, Vol.113 (4), p.791-793

2001

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Enantioselective Desymmetrization ofmeso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of PolyhydroxylatedCelastraceae Sesquiterpene Cores

Angewandte Chemie, 2001-02, Vol.113 (4), p.791-793

2001

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ChemInform Abstract: Chapter 2: Synthetic Methods. Part 5. Protecting Groups

ChemInform, 1999-04, Vol.30 (16), p.no-no

1999

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Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Nature chemical biology, 2012-11, Vol.8 (11), p.920

2012

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Elevated Southern Hemisphere moisture availability during glacial periods

Nature (London), 2024-02, Vol.626 (7998), p.319-326

2024

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Effect of exclusive enteral nutrition on bone turnover in children with Crohn’s disease

Journal of gastroenterology, 2010-04, Vol.45 (4), p.399-405

2010

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Cave opening and fossil accumulation in Naracoorte, Australia, through charcoal and pollen in dated speleothems

Communications earth & environment, 2022-12, Vol.3 (1), p.1-8, Article 210

2022

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Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera

Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model

A Total Synthesis of Estrone Based on a Novel Cascade of Radical Cyclizations

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth

Fragment-based discovery of inhibitors of protein kinase B

Abstract 4748: Discovery of JNJ-42756493, a potent fibroblast growth factor receptor (FGFR) inhibitor using a fragment based approach

Abstract 928: The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors

Enantioselective Desymmetrization of meso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation

Chapter 2. Synthetic methods . Part (v) Protecting groups

Synthetic approaches to celastraceae sesquiterpenoids

Enantioselective Desymmetrization of meso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of Polyhydroxylated Celastraceae Sesquiterpene Cores

Enantioselective Desymmetrization ofmeso-Decalin Diallylic Alcohols by a New Zr-Based Sharpless AE Process: A Novel Approach to the Asymmetric Synthesis of PolyhydroxylatedCelastraceae Sesquiterpene Cores

ChemInform Abstract: Chapter 2: Synthetic Methods. Part 5. Protecting Groups

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Elevated Southern Hemisphere moisture availability during glacial periods

Effect of exclusive enteral nutrition on bone turnover in children with Crohn’s disease

Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence

Cave opening and fossil accumulation in Naracoorte, Australia, through charcoal and pollen in dated speleothems

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