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Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6271-6279

2008

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Reversible inhibition of tomato fruit senescence by antisense RNA

Science (American Association for the Advancement of Science), 1991-10, Vol.254 (5030), p.437-439

1991

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NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

iScience, 2024-06, Vol.27 (6), p.109913-109913, Article 109913

2024

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Identification of the Auxin-responsive Element, AuxRE, in the Primary indoleacetic Acid-inducible Gene, PS-IAA4/5, of Pea (Pisum sativum)

Journal of molecular biology, 1993-10, Vol.233 (4), p.580-596

1993

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Signal Transduction and Ligand Specificity of the Human Monocyte Chemoattractant Protein-1 Receptor in Transfected Embryonic Kidney Cells (∗)

The Journal of biological chemistry, 1995-03, Vol.270 (11), p.5786-5792

1995

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Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

The Journal of immunology (1950), 1999-07, Vol.163 (1), p.380-386

1999

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6398-6411

2010

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DNA elements responsive to auxin

BioEssays, 1996-08, Vol.18 (8), p.647-654

1996

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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6280-6292

2008

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Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1625-1630

1999

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A carcinoembryonic antigen-specific cell therapy selectively targets tumor cells with HLA loss of heterozygosity in vitro and in vivo

Science translational medicine, 2022-03, Vol.14 (634)

2022

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Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking

The Journal of biological chemistry, 1997-01, Vol.272 (2), p.1038-1045

1997

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Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1680-1684

2010

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Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (9), p.2409-2413

2005

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Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4724-4728

2009

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A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy

Toxicology and applied pharmacology, 2022-02, Vol.437, p.115894-115894, Article 115894

2022

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Identification of triazolopyridazinones as potent p38α inhibitors

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1226-1229

2012

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Transcriptional regulation of PS-IAA4/5 and PS-IAA6 early gene expression by indoleacetic acid and protein synthesis inhibitors in pea (Pisum sativum)

Journal of molecular biology, 1995-10, Vol.253 (3), p.396-413

1995

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Two Auxin-Responsive Domains Interact Positively to Induce Expression of the Early Indoleacetic Acid-Inducible Gene PS-IAA4/5

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (8), p.3483-3487

1995

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Differential activation of the primary auxin response genes, PS‐IAA4/5 and PS‐IAA6, during early plant development

The Plant journal : for cell and molecular biology, 1996-05, Vol.9 (5), p.587-599

1996

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Thalidomide analogs and PDE4 inhibition

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2669-2674

1998

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Abstract 2751: The modular Tmod dual_receptor system exploits tumor deletions to achieve robust tumor-selective cytotoxicity

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2751-2751

2022

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Use of a tomato mutant constructed with reverse genetics to study fruit ripening, a complex developmental process

Developmental genetics, 1993, Vol.14 (4), p.282-295

1993

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Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Reversible inhibition of tomato fruit senescence by antisense RNA

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

Identification of the Auxin-responsive Element, AuxRE, in the Primary indoleacetic Acid-inducible Gene, PS-IAA4/5, of Pea (Pisum sativum)

Signal Transduction and Ligand Specificity of the Human Monocyte Chemoattractant Protein-1 Receptor in Transfected Embryonic Kidney Cells (∗)

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

DNA elements responsive to auxin

3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

A carcinoembryonic antigen-specific cell therapy selectively targets tumor cells with HLA loss of heterozygosity in vitro and in vivo

Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking

Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy

Identification of triazolopyridazinones as potent p38α inhibitors

Transcriptional regulation of PS-IAA4/5 and PS-IAA6 early gene expression by indoleacetic acid and protein synthesis inhibitors in pea (Pisum sativum)

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Two Auxin-Responsive Domains Interact Positively to Induce Expression of the Early Indoleacetic Acid-Inducible Gene PS-IAA4/5

Differential activation of the primary auxin response genes, PS‐IAA4/5 and PS‐IAA6, during early plant development

Thalidomide analogs and PDE4 inhibition

Abstract 2751: The modular Tmod dual_receptor system exploits tumor deletions to achieve robust tumor-selective cytotoxicity

Use of a tomato mutant constructed with reverse genetics to study fruit ripening, a complex developmental process

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