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The Case for Development of 11-Aza-artemisinins for Malaria

Current medicinal chemistry, 2015-01, Vol.22 (31), p.3607-3630

2015

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Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action

ChemMedChem, 2012-12, Vol.7 (12), p.2204-2226

2012

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Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

ChemMedChem, 2010-08, Vol.5 (8), p.1282-1299

2010

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Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria

Antimicrobial Agents and Chemotherapy, 2012-01, Vol.56 (1), p.163-173

2012

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Artesunate and Dihydroartemisinin (DHA): Unusual Decomposition Products Formed under Mild Conditions and Comments on the Fitness of DHA as an Antimalarial Drug

ChemMedChem, 2007-10, Vol.2 (10), p.1448-1463

2007

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Artemisone Uptake in Plasmodium falciparum-Infected Erythrocytes

Antimicrobial Agents and Chemotherapy, 2011-02, Vol.55 (2), p.550-556

2011

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A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine

ChemMedChem, 2011-09, Vol.6 (9), p.1603-1615

2011

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The evaluation of the anti‐cancer drug elesclomol that forms a redox‐active copper chelate as a potential anti‐tubercular drug

IUBMB life, 2019-05, Vol.71 (5), p.532-538

2019

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Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model

Veterinary research (Paris), 2016-02, Vol.47 (32), p.32-32, Article 32

2016

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Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins

Frontiers in pharmacology, 2024-01, Vol.14, p.1308400-1308400

2024

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Facile Preparation of N -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

Molecules (Basel, Switzerland), 2018-07, Vol.23 (7), p.1713

2018

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Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

Frontiers in pharmacology, 2022-09, Vol.13, p.988748-988748

2022

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Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs

Frontiers in pharmacology, 2020-09, Vol.11, p.558894-558894

2020

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Preparation of N-Sulfonyl- and N-Carbonyl-11-Azaartemisinins with Greatly Enhanced Thermal Stabilities: in vitro Antimalarial Activities

ChemMedChem, 2007-10, Vol.2 (10), p.1464-1479

2007

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The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

Pharmaceutics, 2021-12, Vol.13 (12), p.2066

2021

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Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites

Frontiers in chemistry, 2020-01, Vol.7, p.901-901

2020

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Elimination of Schistosoma mansoni in infected mice by slow release of artemisone

International journal for parasitology -- drugs and drug resistance, 2017-08, Vol.7 (2), p.241-247

2017

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Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether

Antimicrobial agents and chemotherapy, 2021-07, Vol.65 (8), p.e0099021

2021

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Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: A test of N-glycosylation methodologies on a lipophilic peroxide

Tetrahedron, 2018-09, Vol.74 (38), p.5156-5171

2018

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Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (19), p.3161-3163

2018

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Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.289-292

2018

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Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice

Experimental parasitology, 2023-12, Vol.255, p.108655-108655, Article 108655

2023

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Cover Picture: Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006)

Angewandte Chemie (International ed.), 2006-03, Vol.45 (13), p.1989-1989

2006

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Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class

Angewandte Chemie (International ed.), 2006-03, Vol.45 (13), p.2082-2088

2006

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The Case for Development of 11-Aza-artemisinins for Malaria

Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action

Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria

Artesunate and Dihydroartemisinin (DHA): Unusual Decomposition Products Formed under Mild Conditions and Comments on the Fitness of DHA as an Antimalarial Drug

Artemisone Uptake in Plasmodium falciparum-Infected Erythrocytes

A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine

The evaluation of the anti‐cancer drug elesclomol that forms a redox‐active copper chelate as a potential anti‐tubercular drug

Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model

Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins

Facile Preparation of N -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs

Preparation of N-Sulfonyl- and N-Carbonyl-11-Azaartemisinins with Greatly Enhanced Thermal Stabilities: in vitro Antimalarial Activities

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites

Elimination of Schistosoma mansoni in infected mice by slow release of artemisone

Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether

Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: A test of N-glycosylation methodologies on a lipophilic peroxide

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice

Cover Picture: Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006)

Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class

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