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Redox-directed cancer therapeutics: molecular mechanisms and opportunities

Antioxidants & redox signaling, 2009-12, Vol.11 (12), p.3013

Wondrak, Georg T

2009

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Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth

Redox biology, 2021-02, Vol.39, p.101838, Article 101838

2021

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Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

Diabetes (New York, N.Y.), 2011-11, Vol.60 (11), p.3055-3066

2011

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An Essential Role of NRF2 in Diabetic Wound Healing

Diabetes (New York, N.Y.), 2016-03, Vol.65 (3), p.780-793

2016

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TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

Current medicinal chemistry, 2018, Vol.25 (40), p.5487

2018

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Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin

Nutrients, 2017-12, Vol.9 (12), p.1371

2017

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Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer

Frontiers in oncology, 2022-04, Vol.12, p.887220

2022

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The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes

Journal of investigative dermatology, 2015-06, Vol.135 (6), p.1649-1658

2015

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Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo

Antioxidants & redox signaling, 2013-11, Vol.19 (14), p.1647

2013

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Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

Experimental cell research, 2013-10, Vol.319 (17), p.2673-2683

2013

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Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin

Frontiers in pharmacology, 2018-03, Vol.9, p.287-287

2018

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Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Scientific reports, 2016-01, Vol.6 (1), p.18760, Article 18760

2016

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Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin

Redox biology, 2021-09, Vol.45, p.102042, Article 102042

2021

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Deuterium Oxide (D 2 O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma

Cancers, 2021-02, Vol.13 (4), p.605

2021

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The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

Redox biology, 2013-01, Vol.1 (1), p.532-541

2013

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The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth

Free radical biology & medicine, 2009-01, Vol.46 (2), p.220-231

2009

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Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Cancer prevention research (Philadelphia, Pa.), 2015-05, Vol.8 (5), p.444-454

2015

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Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer

Cancers, 2021-07, Vol.13 (14), p.3608

2021

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Parkinson's Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy

Frontiers in neuroscience, 2018-01, Vol.11, p.737

2018

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UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts

Journal of photochemistry and photobiology. B, Biology, 2013-06, Vol.123, p.1-12

2013

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The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

Autophagy, 2013-12, Vol.9 (12), p.2087-2102

2013

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Melanotransferrin (MELTF, MFI2, CD228) Expression Attenuates Malignant Melanoma Progression in the A375-Luc2 Murine Metastasis Model and Human Patients

Journal of investigative dermatology, 2024-06

2024

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Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Cancers, 2020-05, Vol.12 (6), p.1369

2020

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The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis

Redox biology, 2020-09, Vol.36, p.101594, Article 101594

2020

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Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

Biometals, 2011-10, Vol.24 (5), p.875-890

2011

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Redox-directed cancer therapeutics: molecular mechanisms and opportunities

Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

An Essential Role of NRF2 in Diabetic Wound Healing

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin

Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes

Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin

Deuterium Oxide (D 2 O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer

Parkinson's Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy

UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death

Melanotransferrin (MELTF, MFI2, CD228) Expression Attenuates Malignant Melanoma Progression in the A375-Luc2 Murine Metastasis Model and Human Patients

Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis

Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

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