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Glutamate-gated Chloride Channels

The Journal of biological chemistry, 2012-11, Vol.287 (48), p.40232-40238

Wolstenholme, Adrian J.

2012

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Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

International journal for parasitology, 2014-12, Vol.4 (3), p.164-184

2014

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Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes

PLoS pathogens, 2015-12, Vol.11 (12), p.e1005267-e1005267

2015

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An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus

Molecular pharmacology, 2009-06, Vol.75 (6), p.1347-1355

2009

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EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor

PLoS pathogens, 2020-04, Vol.16 (4), p.e1008396

2020

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Lack of detectable short-term effects of a single dose of ivermectin on the human immune system

Parasites & vectors, 2021-06, Vol.14 (1), p.1-304, Article 304

2021

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Resistance to macrocyclic lactones

Current pharmaceutical biotechnology, 2012-05, Vol.13 (6), p.873

2012

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Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release

PLoS neglected tropical diseases, 2017-01, Vol.11 (1), p.e0005279-e0005279

2017

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Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol

Parasites & vectors, 2018-12, Vol.11 (1), p.671-671, Article 671

2018

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Refugia and anthelmintic resistance: Concepts and challenges

International journal for parasitology -- drugs and drug resistance, 2019-08, Vol.10, p.51-57

2019

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Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus

Molecular and biochemical parasitology, 2011-12, Vol.180 (2), p.99-105

2011

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Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans

PloS one, 2011-07, Vol.6 (7), p.e22390-e22390

2011

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Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?

Parasites & vectors, 2017-11, Vol.10 (Suppl 2), p.480-480, Article 480

2017

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FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways

Biochemical journal, 2013-12, Vol.456 (2), p.219-229

2013

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Surviving in a Toxic World

Science (American Association for the Advancement of Science), 2012-02, Vol.335 (6068), p.545-546

Wolstenholme, Adrian J.

2012

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The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

PLoS pathogens, 2009-07, Vol.5 (7), p.e1000517-e1000517

2009

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Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

International journal for parasitology -- drugs and drug resistance, 2021-12, Vol.17, p.27-35

2021

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Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro

Veterinary parasitology, 2014-11, Vol.206 (1-2), p.38-42

2014

Volltextzugriff (PDF)

Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite

International journal for parasitology -- drugs and drug resistance, 2019-08, Vol.10, p.45-50

2019

Volltextzugriff (PDF)

Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep

Invertebrate neuroscience, 2010-11, Vol.10 (1), p.5-10

Wolstenholme, Adrian J

2010

Volltextzugriff (PDF)

Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on a sheep farm

International journal for parasitology -- drugs and drug resistance, 2021-04, Vol.15, p.134-143

2021

Volltextzugriff (PDF)

Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside

PLoS neglected tropical diseases, 2014-12, Vol.8 (12), p.e3401-e3401

2014

Volltextzugriff (PDF)

Anthelmintics – From Discovery to Resistance III (Indian Rocks Beach, FL, 2018)

International journal for parasitology -- drugs and drug resistance, 2018-12, Vol.8 (3), p.494-495

2018

Volltextzugriff (PDF)

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

Scientific reports, 2015-02, Vol.5 (1), p.8558-8558, Article 8558

2015

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Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species

Glutamate-gated Chloride Channels

Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes

An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus

EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor

Lack of detectable short-term effects of a single dose of ivermectin on the human immune system

Resistance to macrocyclic lactones

Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release

Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol

Refugia and anthelmintic resistance: Concepts and challenges

Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus

Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans

Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?

FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways

Surviving in a Toxic World

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro

Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite

Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep

Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on a sheep farm

Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside

Anthelmintics – From Discovery to Resistance III (Indian Rocks Beach, FL, 2018)

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

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