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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13924-13929

2014

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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

PLoS genetics, 2014-03, Vol.10 (3), p.e1004160-e1004160

2014

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A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

Cell metabolism, 2012-07, Vol.16 (1), p.122-134

2012

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Minireview: Implication of Mitochondria in Insulin Secretion and Action

Endocrinology (Philadelphia), 2006-06, Vol.147 (6), p.2643-2649

2006

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Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

Experimental & molecular medicine, 2024-02, Vol.56 (2), p.273-288

2024

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Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

Diabetologia, 2020-12, Vol.63 (12), p.2628-2640

2020

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Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Cell metabolism, 2011-05, Vol.13 (5), p.601-611

2011

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Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Scientific reports, 2017-03, Vol.7 (1), p.44986-44986, Article 44986

2017

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Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

Cell metabolism, 2012-11, Vol.16 (5), p.625-633

2012

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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Translational psychiatry, 2021-02, Vol.11 (1), p.59-59, Article 59

2021

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Essential Role of Mitochondrial Ca2+ Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells

The Journal of biological chemistry, 2015-02, Vol.290 (7), p.4086-4096

2015

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Synaptotagmins bind calcium to release insulin

American journal of physiology: endocrinology and metabolism, 2008-12, Vol.295 (6), p.E1279-E1286

2008

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Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells

American journal of physiology: endocrinology and metabolism, 2015-06, Vol.308 (11), p.E933-E941

2015

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β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

Diabetes (New York, N.Y.), 2005-06, Vol.54 (6), p.1808-1815

2005

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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

Endocrinology (Philadelphia), 2004-02, Vol.145 (2), p.667-678

2004

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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

Biochemical journal, 2013-03, Vol.450 (3), p.595-605

2013

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Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Diabetes (New York, N.Y.), 2018-03, Vol.67 (3), p.372-384

2018

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Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane

Biomolecules (Basel, Switzerland), 2023-03, Vol.13 (3), p.557

2023

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α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains

Endocrine reviews, 2007-02, Vol.28 (1), p.84-116

2007

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Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release

Diabetes (New York, N.Y.), 2005-06, Vol.54 (6), p.1798-1807

2005

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Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Biochemical journal, 2015-05, Vol.468 (1), p.49-63

2015

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Selective Actions of Mitochondrial Fission/Fusion Genes on Metabolism-Secretion Coupling in Insulin-releasing Cells

The Journal of biological chemistry, 2008-11, Vol.283 (48), p.33347-33356

2008

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Mitochondrial signals drive insulin secretion in the pancreatic β-cell

Molecular and cellular endocrinology, 2012-04, Vol.353 (1-2), p.128-137

2012

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Proteomics Analysis of Insulin Secretory Granules

Molecular & cellular proteomics, 2007-06, Vol.6 (6), p.1007-1017

2007

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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

Minireview: Implication of Mitochondria in Insulin Secretion and Action

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Essential Role of Mitochondrial Ca2+ Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells

Synaptotagmins bind calcium to release insulin

Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells

β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane

α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains

Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Selective Actions of Mitochondrial Fission/Fusion Genes on Metabolism-Secretion Coupling in Insulin-releasing Cells

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

Proteomics Analysis of Insulin Secretory Granules

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

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