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An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Drug metabolism and disposition, 2019-06, Vol.47 (6), p.601-615

2019

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Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

Carcinogenesis (New York), 1993-09, Vol.14 (9), p.1821-1824

1993

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Cellular responses to stress

2014

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123 Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

European journal of cancer supplements, 2010, Vol.8 (7), p.45-46

2010

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391 A phase I clinical trial of CXR1002 in patients (pts) with advanced cancer

European journal of cancer supplements, 2010, Vol.8 (7), p.124-124

2010

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Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

The pharmacogenomics journal, 2009-02, Vol.9 (1), p.61-70

2009

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Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

British journal of dermatology (1951), 2012-02, Vol.166 (2), p.380-388

2012

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Biochemical Society transactions, 2000-02, Vol.28 (2), p.33-41

2000

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Human Cytochrome P450 Enzyme Selectivities in the Oxidation of Chlorinated Benzenes

Toxicology and applied pharmacology, 1995-05, Vol.132 (1), p.44-52

1995

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Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy: GST genotype and PUVA sensitivity

British journal of dermatology (1951), 2012-02, Vol.166 (2), p.380-388

2012

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Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

The Lancet (British edition), 1993-10, Vol.342 (8877), p.963-964

1993

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CYP4B1 Activates 4-Ipomeanol in Rat Lung

Toxicology and applied pharmacology, 1993-12, Vol.123 (2), p.193-198

1993

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Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

Carcinogenesis (New York), 2003-02, Vol.24 (2), p.275-282

2003

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Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

British journal of dermatology (1951), 2006-08, Vol.155 (2), p.275-281

2006

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Role of CAR and PXR in xenobiotic toxicity

Toxicology letters, 2011-08, Vol.205, p.S13-S13

2011

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Human Antiendoplasmic Reticulum Autoantibodies Produced in Aromatic Anticonvulsant Hypersensitivity Reactions Recognize Rodent CYP3A Proteins and a Similarly Regulated Human P450 Enzyme(s)

Biochemical and biophysical research communications, 1993-02, Vol.191 (1), p.32-40

1993

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Electron transfer in human cytochrome P450 reductase

Biochemical Society transactions, 2003-06, Vol.31 (Pt 3), p.497-501

2003

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Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver

Carcinogenesis (New York), 1985-04, Vol.6 (4), p.513-521

1985

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Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

British journal of dermatology (1951), 2007-12, Vol.157 (6), p.1230-1234

2007

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Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

The Lancet (British edition), 1992-06, Vol.339 (8806), p.1375-1377

1992

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Characterization of the nature of chemical species of heterogeneous Ziegler–Natta catalysts for the production of HDPE

Catalysis today, 2005-10, Vol.107, p.451-457

2005

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Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo: Cutaneous gene regulation by topical drugs

British journal of dermatology (1951), 2006-08, Vol.155 (2), p.275-281

2006

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Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450

Toxicology (Amsterdam), 1988-08, Vol.50 (3), p.283-301

1988

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A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid

Journal of medical genetics, 1997-09, Vol.34 (9), p.758-760

1997

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Genetic polymorphisms in xenobiotic metabolism

European journal of cancer (1990), 1994, Vol.30 (13), p.1921-1935

1994

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An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

Cellular responses to stress

123 Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

391 A phase I clinical trial of CXR1002 in patients (pts) with advanced cancer

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Human Cytochrome P450 Enzyme Selectivities in the Oxidation of Chlorinated Benzenes

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy: GST genotype and PUVA sensitivity

Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

CYP4B1 Activates 4-Ipomeanol in Rat Lung

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

Role of CAR and PXR in xenobiotic toxicity

Human Antiendoplasmic Reticulum Autoantibodies Produced in Aromatic Anticonvulsant Hypersensitivity Reactions Recognize Rodent CYP3A Proteins and a Similarly Regulated Human P450 Enzyme(s)

Electron transfer in human cytochrome P450 reductase

Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver

Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

Characterization of the nature of chemical species of heterogeneous Ziegler–Natta catalysts for the production of HDPE

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo: Cutaneous gene regulation by topical drugs

Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450

A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid

Genetic polymorphisms in xenobiotic metabolism

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