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Clinical development times for innovative drugs

Nature reviews. Drug discovery, 2022-11, Vol.21 (11), p.793-794

2022

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Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant

PloS one, 2017-05, Vol.12 (5), p.e0177181

2017

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A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions

Journal of medicinal chemistry, 2021-03, Vol.64 (5), p.2312-2338

2021

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Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

PloS one, 2019-11, Vol.14 (11), p.e0225145-e0225145

2019

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Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Frontiers in molecular neuroscience, 2019-07, Vol.12, p.173-173

2019

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Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

Cell reports (Cambridge), 2019-07, Vol.28 (3), p.670-681.e8

2019

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Investigation of a long non-coding RNA at the 4Q26 coronary artery disease locus

ATHEROSCLEROSIS, 2020-12, Vol.315, p.e37-e37

2020

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Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.1823-1840

2020

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Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126942, Article 126942

2020

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The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

FEBS letters, 2015-01, Vol.589 (1), p.77-83

2015

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The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

Medicinal research reviews, 2020-07, Vol.40 (4), p.1352-1384

2020

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Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases

Bioorganic & medicinal chemistry, 2023-02, Vol.80, p.117170-117170, Article 117170

2023

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Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau -/- mice

Frontiers in neuroscience, 2017-04, Vol.11, p.201-201

2017

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A survey of the clinical pipeline in neuroscience

Bioorganic & medicinal chemistry letters, 2022-01, Vol.56, p.128482-128482, Article 128482

2022

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Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies

Journal of medicinal chemistry, 2020-06, Vol.63 (12), p.6251-6275

2020

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Clinical development times for innovative drugs

Nature reviews. Drug discovery, 2022-11, Vol.21 (11), p.793-794

2022

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The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

Nature medicine, 2017-12, Vol.23 (12), p.1394

2017

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Identification of a Core Amino Acid Motif within the α Subunit of GABA A Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

Cell reports (Cambridge), 2019-07, Vol.28 (3), p.670

2019

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Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy

Scientific reports, 2017-02, Vol.7 (1), p.43198-43198, Article 43198

2017

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Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus

Circulation (New York, N.Y.), 2017-08, Vol.136 (5), p.476-489

2017

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Platelet Inhibition In Carriers Of The Gucy1A3 Coronary Artery Disease Risk Allele

Atherosclerosis, 2019-08, Vol.287, p.e140-e140

2019

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Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro

Frontiers in molecular neuroscience, 2017-02, Vol.10, p.46-46

2017

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Platelet soluble guanylyl cyclase deficiency promotes atherosclerosis in mice

Atherosclerosis, 2022-08, Vol.355, p.19

2022

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Functional investigation of the coronary artery disease gene SVEP1

Basic research in cardiology, 2020-12, Vol.115 (6), p.67-67, Article 67

2020

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Clinical development times for innovative drugs

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant

A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

Investigation of a long non-coding RNA at the 4Q26 coronary artery disease locus

Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau -/- mice

A survey of the clinical pipeline in neuroscience

Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies

Clinical development times for innovative drugs

The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

Identification of a Core Amino Acid Motif within the α Subunit of GABA A Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis

Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus

Platelet Inhibition In Carriers Of The Gucy1A3 Coronary Artery Disease Risk Allele

Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro

Platelet soluble guanylyl cyclase deficiency promotes atherosclerosis in mice

Functional investigation of the coronary artery disease gene SVEP1

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