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Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor

Science (American Association for the Advancement of Science), 2019-07, Vol.365 (6449), p.162-168

2019

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What, Why, Where, and When: Bringing Timing to Immuno-Oncology

Trends in immunology, 2019-01, Vol.40 (1), p.12-21

2019

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Spatiotemporally programming cytokine immunotherapies through protein engineering

Immunological reviews, 2023-11, Vol.320 (1), p.10-28

2023

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A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

Molecular cancer therapeutics, 2009-10, Vol.8 (10), p.2861-2871

2009

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Maximizing response to intratumoral immunotherapy in mice by tuning local retention

Nature communications, 2022-01, Vol.13 (1), p.109-13, Article 109

2022

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An engineered protein antagonist of K-Ras/B-Raf interaction

Scientific reports, 2017-07, Vol.7 (1), p.5831-9, Article 5831

2017

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Biophysical properties of the clinical-stage antibody landscape

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (5), p.944-949

2017

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Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

Advanced drug delivery reviews, 2008-09, Vol.60 (12), p.1421-1434

2008

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Yeast surface display for protein engineering and characterization

Current opinion in structural biology, 2007-08, Vol.17 (4), p.467-473

2007

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Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries

Journal of molecular biology, 2018-01, Vol.430 (1), p.119-130

2018

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Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

Cell, 2015-02, Vol.160 (4), p.785-797

2015

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A mechanistic compartmental model for total antibody uptake in tumors

Journal of theoretical biology, 2012-12, Vol.314, p.57-68

2012

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Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

Journal of molecular biology, 2008-09, Vol.381 (5), p.1238-1252

2008

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Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.3320-3325

2015

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Computational design of antibody-affinity improvement beyond in vivo maturation

Nature biotechnology, 2007-10, Vol.25 (10), p.1171-1176

2007

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Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae

Biotechnology and bioengineering, 2009-08, Vol.103 (6), p.1192-1201

2009

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Practical Theoretic Guidance for the Design of Tumor-Targeting Agents

Methods in Enzymology, 2012, Vol.503, p.255-268

2012

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Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2

Cancer cell, 2015-04, Vol.27 (4), p.489-501

2015

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Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Nature communications, 2018-04, Vol.9 (1), p.1461-18, Article 1461

2018

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Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

Proceedings of the National Academy of Sciences - PNAS, 2022-09, Vol.119 (36), p.e2205983119

2022

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Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity

Nature biomedical engineering, 2022-02, Vol.6 (2), p.129

2022

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CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs

Nature communications, 2024-03, Vol.15 (1), p.1900-1900, Article 1900

2024

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CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies

Blood, 2018-02, Vol.131 (6), p.611-620

2018

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Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface

Structure (London), 2013-11, Vol.21 (11), p.1966-1978

2013

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Molecular Magnetic Resonance Imaging of Tumor Response to Therapy

Scientific reports, 2015-10, Vol.5 (1), p.14759-14759, Article 14759

2015

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Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor

What, Why, Where, and When: Bringing Timing to Immuno-Oncology

Spatiotemporally programming cytokine immunotherapies through protein engineering

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

Maximizing response to intratumoral immunotherapy in mice by tuning local retention

An engineered protein antagonist of K-Ras/B-Raf interaction

Biophysical properties of the clinical-stage antibody landscape

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

Yeast surface display for protein engineering and characterization

Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

A mechanistic compartmental model for total antibody uptake in tumors

Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution

Computational design of antibody-affinity improvement beyond in vivo maturation

Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae

Practical Theoretic Guidance for the Design of Tumor-Targeting Agents

Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity

CD8 + T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs

CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies

Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface

Molecular Magnetic Resonance Imaging of Tumor Response to Therapy

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