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mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects

Pharmacology, biochemistry and behavior, 2020-03, Vol.190, p.172854, Article 172854

Witkin, Jeffrey M.

2020

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Potentiation of AMPA receptors for rapid therapeutic gain in psychiatry has reached a new level of excitement

Neuropsychopharmacology (New York, N.Y.), 2024-01, Vol.49 (1), p.339-340

2024

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The romantic age of pharmacological science

Pharmacology, biochemistry and behavior, 2022-03, Vol.214, p.173354-173354, Article 173354

Witkin, Jeffrey M.

2022

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Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy

CNS & neurological disorders drug targets, 2013-06, Vol.12 (4), p.487-497

2013

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ANXIOLYTICS: Origins, drug discovery, and mechanisms

Pharmacology, biochemistry and behavior, 2024-12, Vol.245, p.173858, Article 173858

2024

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Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?

Biochemical pharmacology, 2024-04, Vol.222, p.116046, Article 116046

2024

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GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Pharmacology & therapeutics (Oxford), 2022-06, Vol.234, p.108035-108035, Article 108035

2022

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Clinical investigations of compounds targeting metabotropic glutamate receptors

Pharmacology, biochemistry and behavior, 2022-09, Vol.219, p.173446-173446, Article 173446

2022

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High Impact AMPAkines Induce a Gq‐Protein Coupled Endoplasmic Calcium Release in Cortical Neurons: A Possible Mechanism for Explaining the Toxicity of High Impact AMPAkines

Synapse (New York, N.Y.), 2024-09, Vol.78 (5), p.e22310-n/a

2024

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Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

Pharmacological reviews, 2018-07, Vol.70 (3), p.621-660

2018

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Synthesis of (−)-11‑O‑Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation

Journal of the American Chemical Society, 2017-07, Vol.139 (28), p.9637-9644

2017

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Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

Pharmacological reviews, 2017-04, Vol.69 (2), p.200-235

2017

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Trace Amines and Their Receptors

Pharmacological reviews, 2018-07, Vol.70 (3), p.549-620

2018

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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological reviews, 2016-07, Vol.68 (3), p.816-871

2016

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Prediction of human efficacious antidepressant doses using the mouse forced swim test

Pharmacology, biochemistry and behavior, 2017-10, Vol.161, p.22-29

2017

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The biology of Nociceptin/Orphanin FQ(N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

Pharmacology & therapeutics (Oxford), 2014-03, Vol.141 (3), p.283-299

2014

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Rapid-Acting Antidepressants

Current pharmaceutical design, 2018-01, Vol.24 (22), p.2556-2563

2018

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Where do we go next in antidepressant drug discovery? A new generation of antidepressants: a pivotal role of AMPA receptor potentiation and mGlu2/3 receptor antagonism

Expert opinion on drug discovery, 2022-10, Vol.17 (10), p.1131-1146

2022

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( R )-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders

International journal of molecular sciences, 2024-06, Vol.25 (12), p.6804

2024

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Mood disorders: Regulation by metabotropic glutamate receptors

Biochemical pharmacology, 2008-03, Vol.75 (5), p.997-1006

2008

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Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611

Biochemical pharmacology, 2018-01, Vol.147, p.191-200

2018

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Synthesis and Receptor Binding Studies of α5 GABAAR Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders

Molecules (Basel, Switzerland), 2023-06, Vol.28 (12), p.4771

2023

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Preclinical characterization of a water-soluble low-impact ampakine prodrug, CX1942 and its active moiety, CX1763

Future medicinal chemistry, 2024-09, p.1-12

2024

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The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders

Pharmacology, biochemistry and behavior, 2022-02, Vol.213, p.173321-173321, Article 173321

2022

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mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects

Potentiation of AMPA receptors for rapid therapeutic gain in psychiatry has reached a new level of excitement

The romantic age of pharmacological science

Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy

ANXIOLYTICS: Origins, drug discovery, and mechanisms

Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?

GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Clinical investigations of compounds targeting metabotropic glutamate receptors

High Impact AMPAkines Induce a Gq‐Protein Coupled Endoplasmic Calcium Release in Cortical Neurons: A Possible Mechanism for Explaining the Toxicity of High Impact AMPAkines

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

Synthesis of (−)-11‑O‑Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

Trace Amines and Their Receptors

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Prediction of human efficacious antidepressant doses using the mouse forced swim test

The biology of Nociceptin/Orphanin FQ(N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

Rapid-Acting Antidepressants

Where do we go next in antidepressant drug discovery? A new generation of antidepressants: a pivotal role of AMPA receptor potentiation and mGlu2/3 receptor antagonism

( R )-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders

Mood disorders: Regulation by metabotropic glutamate receptors

Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611

Synthesis and Receptor Binding Studies of α5 GABAAR Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders

Preclinical characterization of a water-soluble low-impact ampakine prodrug, CX1942 and its active moiety, CX1763

The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders

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