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Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system

Pharmacology & therapeutics (Oxford), 2004-07, Vol.103 (1), p.1-20

2004

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Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression

The Journal of pharmacology and experimental therapeutics, 2017-04, Vol.361 (1), p.68

2017

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mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice

CNS & neurological disorders drug targets, 2013-08, Vol.12 (5), p.554

2013

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The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development

Pharmacology, biochemistry and behavior, 2020-09, Vol.196, p.172996-172996, Article 172996

2020

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Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (31), p.10978-10983

2008

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Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors

Pharmacology, biochemistry and behavior, 2017-06, Vol.157, p.35-40

2017

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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors

Pharmacology, biochemistry and behavior, 2018-07, Vol.170, p.9-13

2018

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R-(−)-ketamine modifies behavioral effects of morphine predicting efficacy as a novel therapy for opioid use disorder1

Pharmacology, biochemistry and behavior, 2020-07, Vol.194, p.172927, Article 172927

2020

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The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Pharmacology, biochemistry and behavior, 2019-05, Vol.180, p.22-31

2019

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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors

Pharmacology, biochemistry and behavior, 2018-07, Vol.170, p.9-13

2018

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Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy

Neuropharmacology, 2018-07, Vol.137, p.332-343

2018

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Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABA A receptors

Pharmacology, biochemistry and behavior, 2017-06, Vol.157, p.35-40

2017

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P.6.007 Experimental pharmacological evaluation of Sydnocarb effects: Comparisons with methamphetamine

European neuropsychopharmacology, 2005, Vol.15, p.S267-S268

2005

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Effects of ifenprodil on stimulatory, discriminative stimulus, and convulsant effects of cocaine

Behavioural pharmacology, 1995-04, Vol.6 (3), p.245-253

1995

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Transient hypersensitivity to apomorphine-induced gnawing after termination of acute effects of a single high dose of cocaine

Behavioural pharmacology, 1994-06, Vol.5 (3), p.289-298

1994

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A pharmacogenetic evaluation of the role of local anesthetic actions in the cocaine kindling process

Brain research, 1991-10, Vol.562 (2), p.251-257

1991

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Effects of D1 dopamine agonists on schedule-controlled behavior in the squirrel monkey

Behavioural pharmacology, 1995-03, Vol.6 (2), p.143-148

1995

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Discriminative stimulus effects of the benzodiazepine receptor partial agonist bretazenil in pigeons and in rats

Behavioural pharmacology, 1996-01, Vol.7 (1), p.72-77

1996

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Effects of d-amphetamine, WIN 35,428, pentobarbital and morphine on schedule-controlled responding in two inbred rat strains that differ in locomotor stimulatory effects of cocaine

Behavioural pharmacology, 1992-10, Vol.3 (5), p.455-464

1992

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Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl-ester (cocaethylene)

Life sciences (1973), 1992, Vol.50 (18), p.1351-1361

1992

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Modulation of the lethal effects of cocaine by cholinomimetics

Life sciences (1973), 1989, Vol.45 (24), p.2295-2301

1989

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Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats

Behavioural pharmacology, 1989, Vol.1 (3), p.247-254

1989

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Stereoselective effects of cocaine

Behavioural pharmacology, 1990, Vol.1 (4), p.347-354

1990

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Central histaminergic H3-receptors and locomotor activity

Inflammation research, 2001-04, Vol.50 Suppl 2 (S2), p.S76-77

2001

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Behavioral rebound hypersensitivity of Depo-minergic function after acute cocaine

Pharmacology, biochemistry and behavior, 1991-05, Vol.39 (1), p.246-246

1991

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Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression

mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice

The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development

Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia

Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors

R-(−)-ketamine modifies behavioral effects of morphine predicting efficacy as a novel therapy for opioid use disorder1

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy

Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABA A receptors

P.6.007 Experimental pharmacological evaluation of Sydnocarb effects: Comparisons with methamphetamine

Effects of ifenprodil on stimulatory, discriminative stimulus, and convulsant effects of cocaine

Transient hypersensitivity to apomorphine-induced gnawing after termination of acute effects of a single high dose of cocaine

A pharmacogenetic evaluation of the role of local anesthetic actions in the cocaine kindling process

Effects of D1 dopamine agonists on schedule-controlled behavior in the squirrel monkey

Discriminative stimulus effects of the benzodiazepine receptor partial agonist bretazenil in pigeons and in rats

Effects of d-amphetamine, WIN 35,428, pentobarbital and morphine on schedule-controlled responding in two inbred rat strains that differ in locomotor stimulatory effects of cocaine

Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl-ester (cocaethylene)

Modulation of the lethal effects of cocaine by cholinomimetics

Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats

Stereoselective effects of cocaine

Central histaminergic H3-receptors and locomotor activity

Behavioral rebound hypersensitivity of Depo-minergic function after acute cocaine

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