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Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Molecular cancer therapeutics, 2008-07, Vol.7 (7), p.1880-1889

2008

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Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4‑d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8103-8124

2016

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Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4-d]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors

Journal of medicinal chemistry, 1998-02, Vol.41 (5), p.742-751

1998

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Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

Journal of medicinal chemistry, 2006-02, Vol.49 (4), p.1475-1485

2006

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DFTMP, an NMR Reagent for Assessing the Near-Neutral pH of Biological Samples

Journal of the American Chemical Society, 2006-09, Vol.128 (38), p.12360-12361

2006

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Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.1915-1926

2001

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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5457-5465

1998

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Intramolecular capture of Pummerer rearrangement intermediates. 3. Interrupted Pummerer rearrangement: capture of tricoordinate sulfur species generated under Pummerer rearrangement conditions

Journal of organic chemistry, 1992-05, Vol.57 (11), p.3094-3097

1992

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2296-2303

1997

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Intramolecular capture of pummerer rearrangement intermediates. I. Synthesis of pyrrolo[2,1-c][1,4]benzothiazines

Journal of heterocyclic chemistry, 1986-05, Vol.23 (3), p.695-699

1986

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Interrupted Pummerer rearrangement : capture of tricoordinate sulfur species generated under Pummerer rearrangement conditions

Journal of organic chemistry, 1992-05, Vol.57 (11), p.3094-3097

1992

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Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

Journal of medicinal chemistry, 1992-01, Vol.35 (1), p.2-14

1992

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Concise Syntheses of the Novel 1H-Pyrrolo[3,2-g]quinazoline Ring System and its [2,3-f] Angular Isomer

Journal of organic chemistry, 1996-02, Vol.61 (3), p.1155-1158

1996

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Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3759-3771

1995

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Concise Syntheses of the Novel 1 H -Pyrrolo[3,2- g ]quinazoline Ring System and its [2,3- f ] Angular Isomer

Journal of organic chemistry, 1996-01, Vol.61 (3), p.1155-1158

1996

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Facile synthesis of thioglucose analogs of the anticancer agent etoposide

Tetrahedron letters, 1991-06, Vol.32 (25), p.2849-2852

1991

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Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

Journal of medicinal chemistry, 1993-06, Vol.36 (12), p.1735-1745

1993

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Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2253-2265

1993

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Synthesis and evaluation of a series of 3,5-disubstituted benzisoxazole-4,7-diones. Potent radiosensitizers in vitro

Journal of medicinal chemistry, 1991-11, Vol.34 (11), p.3290-3294

1991

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Efficient Synthesis of peri-Hydroxylated 9,10-Anthracenedione Ethers via Alkylation of Cesium Phenolates

Synthesis (Stuttgart), 1988, Vol.1988 (9), p.712-714

1988

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The epidemiology of male infertility

Urologic clinics of North America, 2014-02, Vol.41 (1), p.195

2014

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The evolution and ecology of multiple antipredator defences

Journal of evolutionary biology, 2023-07, Vol.36 (7), p.975-991

2023

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Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations

PloS one, 2020-03, Vol.15 (3), p.e0230306-e0230306

2020

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An immuno-northern technique to measure the size of dsRNA byproducts in in vitro transcribed RNA

Electrophoresis, 2024-05

2024

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Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4‑d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

DFTMP, an NMR Reagent for Assessing the Near-Neutral pH of Biological Samples

Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Intramolecular capture of Pummerer rearrangement intermediates. 3. Interrupted Pummerer rearrangement: capture of tricoordinate sulfur species generated under Pummerer rearrangement conditions

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Intramolecular capture of pummerer rearrangement intermediates. I. Synthesis of pyrrolo[2,1-c][1,4]benzothiazines

Interrupted Pummerer rearrangement : capture of tricoordinate sulfur species generated under Pummerer rearrangement conditions

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

Concise Syntheses of the Novel 1H-Pyrrolo[3,2-g]quinazoline Ring System and its [2,3-f] Angular Isomer

Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Concise Syntheses of the Novel 1 H -Pyrrolo[3,2- g ]quinazoline Ring System and its [2,3- f ] Angular Isomer

Facile synthesis of thioglucose analogs of the anticancer agent etoposide

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

Synthesis and evaluation of a series of 3,5-disubstituted benzisoxazole-4,7-diones. Potent radiosensitizers in vitro

Efficient Synthesis of peri-Hydroxylated 9,10-Anthracenedione Ethers via Alkylation of Cesium Phenolates

The epidemiology of male infertility

The evolution and ecology of multiple antipredator defences

Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations

Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

An immuno-northern technique to measure the size of dsRNA byproducts in in vitro transcribed RNA

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