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TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets

PloS one, 2017-10, Vol.12 (10), p.e0187262-e0187262

2017

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Abstract 2720: The CD47-blocking innate immune checkpoint inhibitor, TTI-621, triggers CD47-mediated tumor cell apoptosis

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2720-2720

2018

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Abstract 3854: Preclinical characterization of a novel non-cyclic dinucleotide small molecule STING agonist with potent antitumor activity in mice

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3854-3854

2019

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TTI-621

PloS one, 2017-10, Vol.12 (10), p.e0187262

2017

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DDIS-11. TTI-2341: A NOVEL, ORALLY BIOAVAILABLE, BRAIN-PENETRANT, COVALENT EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR FOR TREATMENT OF GLIOBLASTOMA MULTIFORME (GBM) AND BRAIN METASTASES OF NON-SMALL CELL LUNG CANCER (NSCLC)

Neuro-oncology (Charlottesville, Va.), 2017-11, Vol.19 (suppl_6), p.vi61-vi61

2017

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Abstract 2653: The anti-myeloma activity of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, is enhanced when combined with a proteasome inhibitor

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2653-2653

2017

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Abstract 2709: TTI-622 (SIRPα-IgG4 Fc), a CD47-blocking innate immune checkpoint inhibitor, suppresses tumor growth and demonstrates enhanced efficacy in combination with antitumor antibodies in both hematologic and solid tumor models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2709-2709

2018

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The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.834-840

2015

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Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.775-780

2015

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The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.847-855

2015

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Empirical essays in economics. Part I. Unbalanced productivity growth and its effects on real labor costs. Part II. Inefficiencies in firm governance

Huther, Jeff Winston

1997

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Development of an outsole compound for outdoor footwear

Rubber world, 1997-12, Vol.217 (3), p.26

1997

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Mine First, Reclaim, Then Settle

Landscape architecture, 1980-07, Vol.70 (4), p.401-403

1980

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DOE: Proposed cleanup cut may mean staff reductions

ENR, 1997-08, Vol.239 (7), p.7

Sherie Winston and Jeff Barber

1997

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Labor: Court upholds suspension of helper rules

ENR, 1997-08, Vol.239 (7), p.7

Sherie Winston and Jeff Barber

1997

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Recycling: EPA studying industrial-waste fertilizer

ENR, 1997-08, Vol.239 (7), p.7

Sherie Winston and Jeff Barber

1997

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MIT's Moniz in line for job as under secretary

ENR, 1997-05, Vol.238 (20), p.9

Sherie Winston and Jeff Barber

1997

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White House revises `FAR 15' proposal

ENR, 1997-05, Vol.238 (20), p.9

Sherie Winston and Jeff Barber

1997

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State regulator heads OSHA candidate list

ENR, 1997-05, Vol.238 (20), p.9

Sherie Winston and Jeff Barber

1997

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NotifiVR: Exploring Interruptions and Notifications in Virtual Reality

IEEE transactions on visualization and computer graphics, 2018-04, Vol.24 (4), p.1447-1456

2018

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Extinction vortex dynamics of top predators isolated by urbanization

Ecological applications, 2019-04, Vol.29 (3), p.1-14

2019

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Genomic analysis of mouse retinal development

PLoS biology, 2004-09, Vol.2 (9), p.E247

2004

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First reproductive signs of inbreeding depression in Southern California male mountain lions (Puma concolor)

Theriogenology, 2022-01, Vol.177, p.157-164

2022

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The ecology of human-caused mortality for a protected large carnivore

Proceedings of the National Academy of Sciences - PNAS, 2023-03, Vol.120 (13), p.e2220030120-e2220030120

2023

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Arguments for the biological and predictive relevance of the proportional recovery rule

eLife, 2022-10, Vol.11

2022

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TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets

Abstract 2720: The CD47-blocking innate immune checkpoint inhibitor, TTI-621, triggers CD47-mediated tumor cell apoptosis

Abstract 3854: Preclinical characterization of a novel non-cyclic dinucleotide small molecule STING agonist with potent antitumor activity in mice

TTI-621

DDIS-11. TTI-2341: A NOVEL, ORALLY BIOAVAILABLE, BRAIN-PENETRANT, COVALENT EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR FOR TREATMENT OF GLIOBLASTOMA MULTIFORME (GBM) AND BRAIN METASTASES OF NON-SMALL CELL LUNG CANCER (NSCLC)

Abstract 2653: The anti-myeloma activity of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, is enhanced when combined with a proteasome inhibitor

Abstract 2709: TTI-622 (SIRPα-IgG4 Fc), a CD47-blocking innate immune checkpoint inhibitor, suppresses tumor growth and demonstrates enhanced efficacy in combination with antitumor antibodies in both hematologic and solid tumor models

The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors

Empirical essays in economics. Part I. Unbalanced productivity growth and its effects on real labor costs. Part II. Inefficiencies in firm governance

Development of an outsole compound for outdoor footwear

Mine First, Reclaim, Then Settle

DOE: Proposed cleanup cut may mean staff reductions

Labor: Court upholds suspension of helper rules

Recycling: EPA studying industrial-waste fertilizer

MIT's Moniz in line for job as under secretary

White House revises `FAR 15' proposal

State regulator heads OSHA candidate list

NotifiVR: Exploring Interruptions and Notifications in Virtual Reality

Extinction vortex dynamics of top predators isolated by urbanization

Genomic analysis of mouse retinal development

First reproductive signs of inbreeding depression in Southern California male mountain lions (Puma concolor)

The ecology of human-caused mortality for a protected large carnivore

Arguments for the biological and predictive relevance of the proportional recovery rule

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