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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3260-3268

2015

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A New, Efficient Method for the Synthesis of Bisindolylmaleimides

Journal of organic chemistry, 1998-08, Vol.63 (17), p.6053-6058

1998

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8076-8100

2021

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Salt form selection and characterization of LY333531 mesylate monohydrate

International journal of pharmaceutics, 2000-04, Vol.198 (2), p.239-247

2000

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Synthesis of Novel Retinoid X Receptor-Selective Retinoids

Journal of organic chemistry, 2001-08, Vol.66 (17), p.5772-5782

2001

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115194, Article 115194

2020

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Synthesis, Optimization, and Large-Scale Preparation of the Low-Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition

Organic process research & development, 2020-02, Vol.24 (2), p.306-314

2020

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Practical Asymmetric Fluorination Approach to the Scalable Synthesis of New Fluoroaminothiazine BACE Inhibitors

Organic process research & development, 2018-05, Vol.22 (5), p.650-654

2018

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Synthesis of Rebeccamycin and 11-Dechlororebeccamycin

Journal of organic chemistry, 1999-04, Vol.64 (7), p.2465-2470

1999

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NONCLINICAL PHARMACOLOGICAL CHARACTERIZATION OF THE BACE1 INHIBITOR LY3202626

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P432-P433

2016

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A CORRELATIONAL ANALYSIS OF EXPOSURE AND PHARMACODYNAMIC EFFECTS OF THE BACE1 INHIBITOR LY3202626 IN PDAPP MICE FOLLOWING ACUTE ORAL DOSING

Alzheimer's & dementia, 2016-07, Vol.12 (7), p.P831-P831

2016

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(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

Journal of medicinal chemistry, 1996-07, Vol.39 (14), p.2664-2671

1996

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Design and Synthesis of Dual Peroxisome Proliferator-Activated Receptors γ and δ Agonists as Novel Euglycemic Agents with a Reduced Weight Gain Profile

Journal of medicinal chemistry, 2006-09, Vol.49 (19), p.5649-5652

2006

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Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids: A New Class of Dual PPARα/γ Agonists

Journal of medicinal chemistry, 2001-06, Vol.44 (13), p.2061-2064

2001

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Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2422-2425

2004

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Design and synthesis of a novel class of dual PPARγ/δ agonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.1052-1055

2007

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Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3835-3839

2003

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Two Complementary Approaches toward 2-Alkoxy Carboxylic Acid Synthesis from 1,3-Dioxolan-4-ones

Journal of organic chemistry, 2004-07, Vol.69 (15), p.4948-4953

2004

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Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6744-6749

2007

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Conversion of human-selective PPARα agonists to human/mouse dual agonists: a molecular modeling analysis

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6113-6116

2004

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Macrocyclic Bisindolylmaleimides: Synthesis by Inter- and Intramolecular Alkylation

Journal of organic chemistry, 1998-03, Vol.63 (6), p.1961-1973

1998

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P1‐080: Nonclinical Pharmacological Characterization of the Bace1 Inhibitor LY3202626

Alzheimer's & dementia, 2016-07, Vol.12 (7S_Part_9), p.P432-P433

2016

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P3‐035: A Correlational Analysis of Exposure and Pharmacodynamic Effects of the Bace1 Inhibitor LY3202626 in PDAPP Mice Following Acute Oral Dosing

Alzheimer's & dementia, 2016-07, Vol.12 (7S_Part_17), p.P831-P831

2016

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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

A New, Efficient Method for the Synthesis of Bisindolylmaleimides

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Salt form selection and characterization of LY333531 mesylate monohydrate

Synthesis of Novel Retinoid X Receptor-Selective Retinoids

Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints

Synthesis, Optimization, and Large-Scale Preparation of the Low-Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition

Practical Asymmetric Fluorination Approach to the Scalable Synthesis of New Fluoroaminothiazine BACE Inhibitors

Synthesis of Rebeccamycin and 11-Dechlororebeccamycin

Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species

NONCLINICAL PHARMACOLOGICAL CHARACTERIZATION OF THE BACE1 INHIBITOR LY3202626

A CORRELATIONAL ANALYSIS OF EXPOSURE AND PHARMACODYNAMIC EFFECTS OF THE BACE1 INHIBITOR LY3202626 IN PDAPP MICE FOLLOWING ACUTE ORAL DOSING

(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

Design and Synthesis of Dual Peroxisome Proliferator-Activated Receptors γ and δ Agonists as Novel Euglycemic Agents with a Reduced Weight Gain Profile

Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids: A New Class of Dual PPARα/γ Agonists

Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists

Design and synthesis of a novel class of dual PPARγ/δ agonists

Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors

Two Complementary Approaches toward 2-Alkoxy Carboxylic Acid Synthesis from 1,3-Dioxolan-4-ones

Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists

Conversion of human-selective PPARα agonists to human/mouse dual agonists: a molecular modeling analysis

Macrocyclic Bisindolylmaleimides: Synthesis by Inter- and Intramolecular Alkylation

P1‐080: Nonclinical Pharmacological Characterization of the Bace1 Inhibitor LY3202626

P3‐035: A Correlational Analysis of Exposure and Pharmacodynamic Effects of the Bace1 Inhibitor LY3202626 in PDAPP Mice Following Acute Oral Dosing

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