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The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting

Nature reviews. Drug discovery, 2008-05, Vol.6 (5), p.411-425

Winkles, Jeffrey A

2008

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Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

Current pharmaceutical design, 2016-01, Vol.22 (9), p.1177-1193

2016

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Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

Frontiers in oncology, 2018-10, Vol.8, p.462-462

2018

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EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival

Molecular cancer research, 2018-07, Vol.16 (7), p.1185-1195

2018

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MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain

PloS one, 2018-02, Vol.13 (2), p.e0192240-e0192240

2018

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Regulation of Fibroblast Growth Factor-inducible 14 (Fn14) Expression Levels via Ligand-independent Lysosomal Degradation

The Journal of biological chemistry, 2014-05, Vol.289 (19), p.12976-12988

2014

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The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

Journal of the American Society of Nephrology, 2008-04, Vol.19 (4), p.695-703

2008

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Leveraging Surface Plasmon Resonance to Dissect the Interfacial Properties of Nanoparticles: Implications for Tissue Binding and Tumor Penetration

Nanomedicine, 2019-08, Vol.20, p.102024-102024, Article 102024

2019

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Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer

PloS one, 2017-03, Vol.12 (3), p.e0174557

2017

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TWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain

PloS one, 2013-06, Vol.8 (6), p.e65248

2013

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TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

The EMBO journal, 2006-12, Vol.25 (24), p.5826-5839

2006

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Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Molecular cancer research, 2012-07, Vol.10 (7), p.958-968

2012

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Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas

Biomedicines, 2024-06, Vol.12 (6), p.1230

2024

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TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic

Frontiers in immunology, 2013-01, Vol.4, p.473

2013

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Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues

Oncogene, 2005-01, Vol.24 (2), p.260-266

2005

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Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells

Molecular cancer therapeutics, 2011-07, Vol.10 (7), p.1276-1288

2011

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Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma

Scientific reports, 2018-01, Vol.8 (1), p.1180-15, Article 1180

2018

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Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors

Cancer research (Chicago, Ill.), 2013-07, Vol.73 (14), p.4439-4450

2013

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The TWEAK Receptor Fn14 Is a Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment

Journal of investigative dermatology, 2013-04, Vol.133 (4), p.1052-1062

2013

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Fibroblast Growth Factor-Inducible-14 Is Induced in Axotomized Neurons and Promotes Neurite Outgrowth

The Journal of neuroscience, 2003-10, Vol.23 (29), p.9675-9686

2003

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Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling

Journal of bone and mineral research, 2010-08, Vol.25 (8), p.1771-1783

2010

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A Novel TNF Receptor Family Member Binds TWEAK and Is Implicated in Angiogenesis

Immunity (Cambridge, Mass.), 2001-11, Vol.15 (5), p.837-846

2001

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TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia

Journal of cerebral blood flow and metabolism, 2007-03, Vol.27 (3), p.534-544

2007

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Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment

Advanced drug delivery reviews, 2022-09, Vol.188, p.114415-114415, Article 114415

2022

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Emerging translational approaches for brain cancer therapeutics

Advanced drug delivery reviews, 2022-10, Vol.189, p.114522-114522, Article 114522

2022

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The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival

MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain

Regulation of Fibroblast Growth Factor-inducible 14 (Fn14) Expression Levels via Ligand-independent Lysosomal Degradation

The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

Leveraging Surface Plasmon Resonance to Dissect the Interfacial Properties of Nanoparticles: Implications for Tissue Binding and Tumor Penetration

Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer

TWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain

TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas

TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic

Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues

Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells

Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma

Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors

The TWEAK Receptor Fn14 Is a Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment

Fibroblast Growth Factor-Inducible-14 Is Induced in Axotomized Neurons and Promotes Neurite Outgrowth

Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling

A Novel TNF Receptor Family Member Binds TWEAK and Is Implicated in Angiogenesis

TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia

Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment

Emerging translational approaches for brain cancer therapeutics

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