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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

Nature communications, 2017-06, Vol.8 (1), p.15916-15916, Article 15916

2017

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Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (21), p.8253-8258

2012

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Lys05: A new lysosomal autophagy inhibitor

Autophagy, 2012-09, Vol.8 (9), p.1383-1384

2012

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Lysosomal lipid peroxidation regulates tumor immunity

The Journal of clinical investigation, 2023-04, Vol.133 (8), p.1-19

2023

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De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (17), p.6968-6973

2009

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Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

eLife, 2016-04, Vol.5

2016

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Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury

PloS one, 2024-04, Vol.19 (4), p.e0301824

2024

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The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

PLoS pathogens, 2015-10, Vol.11 (10), p.e1005184-e1005184

2015

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Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

Immunity (Cambridge, Mass.), 2014-10, Vol.41 (4), p.579-591

2014

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Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

Molecular cancer research, 2017-03, Vol.15 (3), p.250-258

2017

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Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (10), p.3492-3497

2012

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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

JCI insight, 2020-09, Vol.5 (17)

2020

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SIRT1 is downregulated by autophagy in senescence and ageing

Nature cell biology, 2020-10, Vol.22 (10), p.1170

2020

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Synthesis of the Core Ring System of the Antiosteoporotic Citrofulvicin

Organic letters, 2021-06, Vol.23 (12), p.4575-4578

2021

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Design and Synthesis of Inhibitors of Hedgehog Signaling Based on the Alkaloid Cyclopamine

Organic letters, 2009-07, Vol.11 (13), p.2824-2827

2009

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Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

Molecular & cellular oncology, 2018-01, Vol.5 (1), p.e1395504-e1395504

2018

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Studies directed toward the synthesis of nakadomarin A

Tetrahedron letters, 2011-04, Vol.52 (17), p.2162-2164

2011

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HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest

Cancer research (Chicago, Ill.), 2007-02, Vol.67 (3), p.1221-1227

2007

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Synthesis of and Metal Complexation with a Chiral Cyclam

Journal of organic chemistry, 2021-04, Vol.86 (7), p.5417-5422

2021

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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

JCI insight, 2022-10, Vol.7 (20)

2022

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PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

Cancer discovery, 2019-02, Vol.9 (2), p.220-229

2019

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Stereoselective Synthesis of F-Ring Saturated Estrone-Derived Inhibitors of Hedgehog Signaling Based on Cyclopamine

Organic letters, 2011-09, Vol.13 (18), p.4786-4789

2011

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Synthesis and Applications of the C2-Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Journal of organic chemistry, 2020-06, Vol.85 (11), p.7424-7432

2020

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Synthesis and Applications of the C 2 -Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Journal of organic chemistry, 2020-06, Vol.85 (11), p.7424-7432

2020

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Synthesis of Substituted Phenazines via Palladium-Catalyzed Aryl Ligation

Heterocycles, 2012, Vol.84 (2), p.1345

2012

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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Lys05: A new lysosomal autophagy inhibitor

Lysosomal lipid peroxidation regulates tumor immunity

De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

SIRT1 is downregulated by autophagy in senescence and ageing

Synthesis of the Core Ring System of the Antiosteoporotic Citrofulvicin

Design and Synthesis of Inhibitors of Hedgehog Signaling Based on the Alkaloid Cyclopamine

Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

Studies directed toward the synthesis of nakadomarin A

HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest

Synthesis of and Metal Complexation with a Chiral Cyclam

PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

Stereoselective Synthesis of F-Ring Saturated Estrone-Derived Inhibitors of Hedgehog Signaling Based on Cyclopamine

Synthesis and Applications of the C2-Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Synthesis and Applications of the C 2 -Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Synthesis of Substituted Phenazines via Palladium-Catalyzed Aryl Ligation

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