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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

Nature communications, 2017-06, Vol.8 (1), p.15916-15916, Article 15916

2017

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SIRT1 is downregulated by autophagy in senescence and ageing

Nature cell biology, 2020-10, Vol.22 (10), p.1170

2020

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Synthesis of the Core Ring System of the Antiosteoporotic Citrofulvicin

Organic letters, 2021-06, Vol.23 (12), p.4575-4578

2021

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Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (21), p.8253-8258

2012

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The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

PLoS pathogens, 2015-10, Vol.11 (10), p.e1005184-e1005184

2015

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Synthesis of and Metal Complexation with a Chiral Cyclam

Journal of organic chemistry, 2021-04, Vol.86 (7), p.5417-5422

2021

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Lysosomal lipid peroxidation regulates tumor immunity

The Journal of clinical investigation, 2023-04, Vol.133 (8), p.1-19

2023

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De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (17), p.6968-6973

2009

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Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma

The Journal of clinical investigation, 2014-03, Vol.124 (3), p.1406-1417

2014

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PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

Cancer discovery, 2019-02, Vol.9 (2), p.220-229

2019

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Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

eLife, 2016-04, Vol.5

2016

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Synthesis and Applications of the C 2 -Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Journal of organic chemistry, 2020-06, Vol.85 (11), p.7424-7432

2020

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Synthesis and Applications of the C2-Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Journal of organic chemistry, 2020-06, Vol.85 (11), p.7424-7432

2020

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Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

Leukemia, 2019-04, Vol.33 (4), p.981-994

2019

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Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

Immunity (Cambridge, Mass.), 2014-10, Vol.41 (4), p.579-591

2014

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A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

Cancer discovery, 2017-11, Vol.7 (11), p.1266-1283

2017

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Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

Molecular cancer research, 2017-03, Vol.15 (3), p.250-258

2017

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Anticancer properties of bisaminoquinolines with modified linkers

Bioorganic & medicinal chemistry letters, 2021-10, Vol.49, p.128272-128272, Article 128272

2021

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ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

Cancer research (Chicago, Ill.), 2017-11, Vol.77 (21), p.5873-5885

2017

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Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain

Bioorganic & medicinal chemistry letters, 2021-10, Vol.50, p.128313-128313, Article 128313

2021

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Gilbert Stork (1921–2017)

Angewandte Chemie International Edition, 2018-01, Vol.57 (1), p.36-36

International ed. in English, 2018

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Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure–Activity Relationships

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2311-2323

2012

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A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

International journal of molecular sciences, 2019-11, Vol.20 (23), p.5881

2019

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N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers

Journal of medicinal chemistry, 2018-06, Vol.61 (11), p.5034-5046

2018

Volltextzugriff (PDF)

Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia

Gastroenterology (New York, N.Y. 1943), 2020-09, Vol.159 (3), p.1068-1084.e2

2020

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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

SIRT1 is downregulated by autophagy in senescence and ageing

Synthesis of the Core Ring System of the Antiosteoporotic Citrofulvicin

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Synthesis of and Metal Complexation with a Chiral Cyclam

Lysosomal lipid peroxidation regulates tumor immunity

De Novo Design and in vivo Activity of Conformationally Restrained Antimicrobial Arylamide Foldamers

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

Synthesis and Applications of the C 2 -Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Synthesis and Applications of the C2-Symmetrical Diamine 2,7-Diazabicyclo[4.4.1]undecane

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

Anticancer properties of bisaminoquinolines with modified linkers

ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma

Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain

Gilbert Stork (1921–2017)

Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure–Activity Relationships

A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers

Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia

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