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A COVID‐19 human viral challenge model. Learning from experience

Influenza and other respiratory viruses, 2020-11, Vol.14 (6), p.747-756

2020

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The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

Respiratory research, 2018-06, Vol.19 (1), p.123-15, Article 123

2018

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Phase 2 Randomized Trial of the Safety and Efficacy of MHAA4549A, a Broadly Neutralizing Monoclonal Antibody, in a Human Influenza A Virus Challenge Model

Antimicrobial agents and chemotherapy, 2017-11, Vol.61 (11)

2017

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An Intranasal Proteosome-Adjuvanted Trivalent Influenza Vaccine Is Safe, Immunogenic & Efficacious in the Human Viral Influenza Challenge Model. Serum IgG & Mucosal IgA Are Important Correlates of Protection against Illness Associated with Infection

PloS one, 2016-12, Vol.11 (12), p.e0163089

2016

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The effective rate of influenza reassortment is limited during human infection

PLoS pathogens, 2017-02, Vol.13 (2), p.e1006203-e1006203

2017

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Inhibition of viral and bacterial trigger-stimulated prostaglandin E by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

SAGE open medicine, 2020-09, Vol.8

2020

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A Tool for Investigating Asthma and COPD Exacerbations: A Newly Manufactured and Well Characterised GMP Wild-Type Human Rhinovirus for Use in the Human Viral Challenge Model

PloS one, 2016-12, Vol.11 (12), p.e0166113-e0166113

2016

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The manufacturing of human viral challenge agents for use in clinical studies to accelerate the drug development process

BMC research notes, 2018-08, Vol.11 (1), p.620-620, Article 620

2018

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Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

PloS one, 2016-01, Vol.11 (1), p.e0145902-e0145902

2016

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Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination

PloS one, 2013-08, Vol.8 (8), p.e71376-e71376

2013

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Correction: Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

PloS one, 2016-06, Vol.11 (6), p.e0157211-e0157211

2016

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Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge

PloS one, 2014-05, Vol.9 (5), p.e93761-e93761

2014

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Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine

Vaccine, 2010-09, Vol.28 (39), p.6527-6541

2010

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Flu: Effect of Vaccine in Elderly Care Home Residents: A Randomized Trial

Journal of the American Geriatrics Society (JAGS), 2007-12, Vol.55 (12), p.1912-1920

2007

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Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study

The Journal of infectious diseases, 2022-08, Vol.226 (3), p.396-406

2022

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Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

Nature medicine, 2012-02, Vol.18 (2), p.274-280

2012

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Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

The New England journal of medicine, 2015-11, Vol.373 (21), p.2048-2058

2015

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Preliminary Assessment of the Efficacy of a T-Cell-Based Influenza Vaccine, MVA-NP+M1, in Humans

Clinical infectious diseases, 2012-07, Vol.55 (1), p.19-25

2012

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Inhibition of viral and bacterial trigger-stimulated prostaglandin E2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

SAGE open medicine, 2020, Vol.8, p.2050312120960568-2050312120960568

2020

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Inhibition of viral and bacterial trigger-stimulated prostaglandin E 2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

SAGE open medicine, 2020-01, Vol.8, p.205031212096056

2020

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Inhibition of viral and bacterial trigger-stimulated prostaglandin E 2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

SAGE open medicine, 2020, Vol.8, p.2050312120960568

2020

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A Synthetic Influenza Virus Vaccine Induces a Cellular Immune Response That Correlates with Reduction in Symptomatology and Virus Shedding in a Randomized Phase Ib Live-Virus Challenge in Humans

Clinical and vaccine immunology, 2015-07, Vol.22 (7), p.828-835

2015

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Re-Inventing the Common Cold Institute for the 21st Century

Journal of human virology & retrovirology, 2016-01, Vol.3 (1)

Lambkin-Williams, Rob

2016

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DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

Vaccine, 2009-04, Vol.27 (18), p.2506-2512

2009

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Virus-Specific Antibody Secreting Cell, Memory B-cell, and Sero-Antibody Responses in the Human Influenza Challenge Model

The Journal of infectious diseases, 2014-05, Vol.209 (9), p.1354-1361

2014

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A COVID‐19 human viral challenge model. Learning from experience

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

Phase 2 Randomized Trial of the Safety and Efficacy of MHAA4549A, a Broadly Neutralizing Monoclonal Antibody, in a Human Influenza A Virus Challenge Model

An Intranasal Proteosome-Adjuvanted Trivalent Influenza Vaccine Is Safe, Immunogenic & Efficacious in the Human Viral Influenza Challenge Model. Serum IgG & Mucosal IgA Are Important Correlates of Protection against Illness Associated with Infection

The effective rate of influenza reassortment is limited during human infection

Inhibition of viral and bacterial trigger-stimulated prostaglandin E by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

A Tool for Investigating Asthma and COPD Exacerbations: A Newly Manufactured and Well Characterised GMP Wild-Type Human Rhinovirus for Use in the Human Viral Challenge Model

The manufacturing of human viral challenge agents for use in clinical studies to accelerate the drug development process

Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination

Correction: Accelerating Influenza Research: Vaccines, Antivirals, Immunomodulators and Monoclonal Antibodies. The Manufacture of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model

Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge

Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine

Flu: Effect of Vaccine in Elderly Care Home Residents: A Randomized Trial

Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

Preliminary Assessment of the Efficacy of a T-Cell-Based Influenza Vaccine, MVA-NP+M1, in Humans

Inhibition of viral and bacterial trigger-stimulated prostaglandin E2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

Inhibition of viral and bacterial trigger-stimulated prostaglandin E 2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

Inhibition of viral and bacterial trigger-stimulated prostaglandin E 2 by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line

A Synthetic Influenza Virus Vaccine Induces a Cellular Immune Response That Correlates with Reduction in Symptomatology and Virus Shedding in a Randomized Phase Ib Live-Virus Challenge in Humans

Re-Inventing the Common Cold Institute for the 21st Century

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

Virus-Specific Antibody Secreting Cell, Memory B-cell, and Sero-Antibody Responses in the Human Influenza Challenge Model

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