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Acyclic cyanamide-based inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.3039-3043

2005

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Design of Potent, Selective, and Orally Bioavailable Inhibitors of Cysteine Protease Cathepsin K

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.588-599

2004

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Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells

Physiological genomics, 2001-02, Vol.5 (1), p.11-19

2001

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Novel and potent cyclic cyanamide-based cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1815-1819

2005

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Agouti structure and function: characterization of a potent .alpha.-melanocyte stimulating hormone receptor antagonist

Biochemistry (Easton), 1995-09, Vol.34 (38), p.12341-12346

1995

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Hydration Changes Implicated in the Remarkable Temperature-Dependent Membrane Permeation of Cyclosporin A

Biochemistry (Easton), 2000-06, Vol.39 (25), p.7621-7630

2000

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Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.978-983

2006

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Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1735-1739

2006

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P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3540-3546

2005

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Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4897-4902

2004

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Exploration of the P1 SAR of aldehyde cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.275-278

2004

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Agouti Antagonism of Melanocortin-4 Receptor: Greater Effect with Desacetyl-α-Melanocyte-Stimulating Hormone (MSH) than withα -MSH

Endocrinology (Philadelphia), 1999-05, Vol.140 (5), p.2167-2172

1999

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Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1

Protein expression and purification, 2001-04, Vol.21 (3), p.367-377

2001

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Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

Biochemistry (Easton), 1997-11, Vol.36 (46), p.14250-14261

1997

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Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors

Biochemistry (Easton), 1997-02, Vol.36 (8), p.2084-2090

1997

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Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3425-3429

2004

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Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding

Protein expression and purification, 1997-03, Vol.9 (2), p.191-202

1997

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Replication-Associated Activities of Purified Human Papillomavirus Type 11 E1 Helicase

Protein expression and purification, 2000-03, Vol.18 (2), p.148-159

2000

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Product Release Is the Major Contributor tok cat for the Hepatitis C Virus Helicase-catalyzed Strand Separation of Short Duplex DNA

The Journal of biological chemistry, 1998-07, Vol.273 (30), p.18906-18914

1998

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Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor-α-converting Enzyme (TACE)

The Journal of biological chemistry, 1999-10, Vol.274 (43), p.30563-30570

1999

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P 2–P 3 conformationally constrained ketoamide-based inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3540-3546

2005

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Solution Structure of the Human pp60c-src SH2 Domain Complexed with a Phosphorylated Tyrosine Pentapeptide

Biochemistry (Easton), 1995-02, Vol.34 (7), p.2107-2121

1995

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Potent and selective P 2–P 3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P 1′, P 1, and/or P 3 substitutions

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4897-4902

2004

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Catalytic Activity of the SH2 Domain of Human pp60c-src; Evidence from NMR, Mass Spectrometry, Site-Directed Mutagenesis and Kinetic Studies for an Inherent Phosphatase Activity

Biochemistry (Easton), 1995-11, Vol.34 (46), p.15351-15358

1995

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Novel, potent P super(2)-P super(3) pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (6), p.1735-1739

2006

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Acyclic cyanamide-based inhibitors of cathepsin K

Design of Potent, Selective, and Orally Bioavailable Inhibitors of Cysteine Protease Cathepsin K

Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells

Novel and potent cyclic cyanamide-based cathepsin K inhibitors

Agouti structure and function: characterization of a potent .alpha.-melanocyte stimulating hormone receptor antagonist

Hydration Changes Implicated in the Remarkable Temperature-Dependent Membrane Permeation of Cyclosporin A

Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions

Exploration of the P1 SAR of aldehyde cathepsin K inhibitors

Agouti Antagonism of Melanocortin-4 Receptor: Greater Effect with Desacetyl-α-Melanocyte-Stimulating Hormone (MSH) than withα -MSH

Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1

Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors

Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors

Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding

Replication-Associated Activities of Purified Human Papillomavirus Type 11 E1 Helicase

Product Release Is the Major Contributor tok cat for the Hepatitis C Virus Helicase-catalyzed Strand Separation of Short Duplex DNA

Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor-α-converting Enzyme (TACE)

P 2–P 3 conformationally constrained ketoamide-based inhibitors of cathepsin K

Solution Structure of the Human pp60c-src SH2 Domain Complexed with a Phosphorylated Tyrosine Pentapeptide

Potent and selective P 2–P 3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P 1′, P 1, and/or P 3 substitutions

Catalytic Activity of the SH2 Domain of Human pp60c-src; Evidence from NMR, Mass Spectrometry, Site-Directed Mutagenesis and Kinetic Studies for an Inherent Phosphatase Activity

Novel, potent P super(2)-P super(3) pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

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