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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (42), p.15072-15077

2014

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The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Blood, 2006-01, Vol.107 (1), p.176-183

2006

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Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Journal of leukocyte biology, 2009-02, Vol.85 (2), p.278-288

2009

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Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1298-1303

2017

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The JAK kinases: Not just another kinase drug discovery target

Seminars in cell & developmental biology, 2008-08, Vol.19 (4), p.319-328

Wilks, Andrew F.

2008

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The Use of JAK-specific inhibitors as chemical biology tools

Methods in molecular biology (Clifton, N.J.), 2013, Vol.967, p.99

2013

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The 2.7 Å Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain

Journal of molecular biology, 2007-03, Vol.367 (3), p.839-847

2007

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Plasmodium kinases as targets for new-generation antimalarials

Future medicinal chemistry, 2012-12, Vol.4 (18), p.2295-2310

2012

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CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo

Molecular cancer therapeutics, 2009-11, Vol.8 (11), p.3036-3045

2009

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Vascular Endothelial Growth Factor D (VEGF-D) is a Ligand for the Tyrosine Kinases VEGF Receptor 2 (Flk1) and VEGF Receptor 3 (Flt4)

Proceedings of the National Academy of Sciences - PNAS, 1998-01, Vol.95 (2), p.548-553

1998

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c-FMS inhibitors: a patent review

Expert opinion on therapeutic patents, 2011-02, Vol.21 (2), p.147-165

2011

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Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

Oncotarget, 2017-08, Vol.8 (35), p.57948-57963

2017

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Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5887-5892

2009

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CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations

The FASEB journal, 2006-09, Vol.20 (11), p.1921-1923

2006

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Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence

Cancer research (Chicago, Ill.), 1996-01, Vol.56 (2), p.393-401

1996

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The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo

The Journal of pharmacology and experimental therapeutics, 2011-12, Vol.339 (3), p.799

2011

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Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk

Nature genetics, 2000-08, Vol.25 (4), p.414-418

2000

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Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4639-4642

2009

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The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Nature (London), 1993-11, Vol.366 (6451), p.129-135

1993

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Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

Nature (London), 1993-12, Vol.366 (6455), p.580-583

1993

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A Mutant Form of Vascular Endothelial Growth Factor (VEGF) That Lacks VEGF Receptor-2 Activation Retains the Ability to Induce Vascular Permeability

The Journal of biological chemistry, 1999-12, Vol.274 (49), p.34884-34892

1999

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Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1206-1209

2009

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Tyrosine Kinase JAK1 is Associated with the Granulocyte-Colony-Stimulating Factor Receptor and Both Become Tyrosine-Phosphorylated after Receptor Activation

Proceedings of the National Academy of Sciences - PNAS, 1994-04, Vol.91 (8), p.2985-2988

1994

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Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on Vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding

Journal of cardiovascular pharmacology, 2008-11, Vol.52 (5), p.403-412

2008

Volltextzugriff (PDF)

The Expression Patterns of Guidance Receptors, DCC and Neogenin, Are Spatially and Temporally Distinct throughout Mouse Embryogenesis

Developmental biology, 1997-12, Vol.192 (2), p.258-273

1997

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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

The JAK kinases: Not just another kinase drug discovery target

The Use of JAK-specific inhibitors as chemical biology tools

The 2.7 Å Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain

Plasmodium kinases as targets for new-generation antimalarials

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo

Vascular Endothelial Growth Factor D (VEGF-D) is a Ligand for the Tyrosine Kinases VEGF Receptor 2 (Flk1) and VEGF Receptor 3 (Flt4)

c-FMS inhibitors: a patent review

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)

CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations

Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence

The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo

Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

A Mutant Form of Vascular Endothelial Growth Factor (VEGF) That Lacks VEGF Receptor-2 Activation Retains the Ability to Induce Vascular Permeability

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Tyrosine Kinase JAK1 is Associated with the Granulocyte-Colony-Stimulating Factor Receptor and Both Become Tyrosine-Phosphorylated after Receptor Activation

Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on Vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding

The Expression Patterns of Guidance Receptors, DCC and Neogenin, Are Spatially and Temporally Distinct throughout Mouse Embryogenesis

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