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Following evolution's lead to a single residue switch for diterpene synthase product outcome

Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (18), p.7397-7401

2007

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Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores

Molecular ecology, 2018-02, Vol.27 (3), p.723-736

2018

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Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1

Biochemistry (Easton), 2020-04, Vol.59 (15), p.1537-1548

2020

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Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6

Molecular pharmacology, 2020-09, Vol.98 (3), p.267-279

2020

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Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist (Neotoma stephensi) and a generalist (Neotoma albigula)

Molecular ecology, 2020-05, Vol.29 (9), p.1674-1683

2020

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Functional characterization of the rice kaurene synthase-like gene family

Phytochemistry (Oxford), 2007-02, Vol.68 (3), p.312-326

2007

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Plasticity of CYP2B enzymes: structural and solution biophysical methods

Current drug metabolism, 2012-02, Vol.13 (2), p.167-176

2012

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Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

Biochemistry (Easton), 2012-09, Vol.51 (37), p.7225-7238

2012

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Solution Structural Behavior of UBAN Domains Revealed by Coarse‐Grained Computer Simulations

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

Wilderman, Ross

2020

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Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis

Plant physiology (Bethesda), 2004-08, Vol.135 (4), p.2098-2105

2004

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Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions

Plant physiology (Bethesda), 2004-12, Vol.136 (4), p.4228-4236

2004

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Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Molecular pharmacology, 2016-04, Vol.89 (4), p.435-445

2016

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Cytochrome P450 2B diversity in a dietary specialist—the red tree vole (Arborimus longicaudus)

Journal of mammalogy, 2018-06, Vol.99 (3), p.578-585

2018

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Tyrosine nitration contributes to nitric oxide-stimulated degradation of CYP2B6

Molecular pharmacology, 2020-09, Vol.98 (3), p.MOLPHARM-AR-2020-000020-279

2020

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Investigation by site‐directed mutagenesis of the role of cytochrome P450 2B4 non‐active‐site residues in protein–ligand interactions based on crystal structures of the ligand‐bound enzyme

The FEBS journal, 2012-05, Vol.279 (9), p.1607-1620

2012

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Using NMR Derived Structural Information Complemented by Molecular Docking and MM/GBSA Rescoring to Mitigate CYP3A4 Time‐Dependent Inhibition

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: Potent Mechanism-Based Inhibitors of Recombinant ent-Kaurene Synthase from Arabidopsis thaliana

Journal of the American Chemical Society, 2007-10, Vol.129 (41), p.12453-12460

2007

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Using CYP3A4 NMR derived structural information to mitigate time‐dependent inhibition due to diltiazem metabolism

The FASEB journal, 2019-04, Vol.33 (S1), p.673.3-673.3

2019

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A Modular Approach for Facile Biosynthesis of Labdane-Related Diterpenes

Journal of the American Chemical Society, 2007-05, Vol.129 (21), p.6684-6685

2007

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase

Journal of the American Chemical Society, 2007-12, Vol.129 (51), p.15736-15737

2007

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Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7‑Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations

Biochemistry (Easton), 2016-04, Vol.55 (13), p.1997-2007

2016

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Rational Re-Engineering of the O‑Dealkylation of 7‑Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida

Biochemistry (Easton), 2017-04, Vol.56 (16), p.2238-2246

2017

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Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6

Journal of the American Chemical Society, 2013-07, Vol.135 (28), p.10433-10440

2013

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Molecular dynamics simulations reveal that tyrosine nitration leads to destabilization of CYP2B6 secondary structure

The FASEB journal, 2018-04, Vol.32 (S1), p.lb651-lb651

2018

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Following evolution's lead to a single residue switch for diterpene synthase product outcome

Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores

Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1

Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6

Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist (Neotoma stephensi) and a generalist (Neotoma albigula)

Functional characterization of the rice kaurene synthase-like gene family

Plasticity of CYP2B enzymes: structural and solution biophysical methods

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

Solution Structural Behavior of UBAN Domains Revealed by Coarse‐Grained Computer Simulations

Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis

Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Cytochrome P450 2B diversity in a dietary specialist—the red tree vole (Arborimus longicaudus)

Tyrosine nitration contributes to nitric oxide-stimulated degradation of CYP2B6

Investigation by site‐directed mutagenesis of the role of cytochrome P450 2B4 non‐active‐site residues in protein–ligand interactions based on crystal structures of the ligand‐bound enzyme

Using NMR Derived Structural Information Complemented by Molecular Docking and MM/GBSA Rescoring to Mitigate CYP3A4 Time‐Dependent Inhibition

16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: Potent Mechanism-Based Inhibitors of Recombinant ent-Kaurene Synthase from Arabidopsis thaliana

Using CYP3A4 NMR derived structural information to mitigate time‐dependent inhibition due to diltiazem metabolism

A Modular Approach for Facile Biosynthesis of Labdane-Related Diterpenes

Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7‑Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations

Rational Re-Engineering of the O‑Dealkylation of 7‑Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida

Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6

Molecular dynamics simulations reveal that tyrosine nitration leads to destabilization of CYP2B6 secondary structure

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