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Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1813-1822

2005

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THU0236 Once-Daily Dosing of GLPG0634, a Selective JAK1 Inhibitor, is Supported by Its Active Metabolite

Annals of the rheumatic diseases, 2013-06, Vol.72 (Suppl 3), p.A244-A245

2013

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Stereoselective and Efficient Synthesis of (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

Organic letters, 2005-12, Vol.7 (26), p.5917-5920

2005

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OP0263 Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial

Annals of the rheumatic diseases, 2013-06, Vol.71 (Suppl 3), p.145-145

2013

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GLPG0187 inhibits progression of established bone metastasis and achieves maximum efficacy when combined with standard-of-care metastatic breast cancer treatments

Bone (New York, N.Y.), 2011-01, Vol.48 (1), p.S45-S45

2011

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PP 87 Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models

European journal of cancer (1990), 2011, Vol.47, p.S28-S28

2011

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TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

Antimicrobial Agents and Chemotherapy, 2005-06, Vol.49 (6), p.2314-2321

2005

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Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

Journal of Virology, 2004-11, Vol.78 (21), p.12012-12021

2004

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Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors of HIV-1 Integrase

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1930-1940

2005

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Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1965-1973

2005

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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2072-2079

2005

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5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2383-2389

1991

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Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models

European journal of cancer (1990), 2011-10, Vol.47, p.S28-S28

2011

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Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus

The Journal of biological chemistry, 1994-03, Vol.269 (11), p.8036-8043

1994

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Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

Journal of medicinal chemistry, 1991-06, Vol.34 (6), p.1767-1772

1991

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Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

Tetrahedron letters, 1992, Vol.33 (49), p.7609-7612

1992

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Synthesis of thymidine from 5-iodo-2′-deoxyuridine

Tetrahedron letters, 1991, Vol.32 (34), p.4397-4400

1991

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Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2′-Deoxyuridine

Nucleosides & nucleotides, 1995-05, Vol.14 (3-5), p.525-528

1995

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2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation

Antiviral chemistry & chemotherapy, 1995-08, Vol.6 (4), p.262-270

1995

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Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogs

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.538-543

1993

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Synthesis of Thymidine Analogues with a Cyanoimido Substituent

Nucleosides & nucleotides, 1991-01, Vol.10 (1-3), p.583-584

1991

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Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.868-873

1990

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Synthesis of 8‐Mercapto‐2′,3′‐Dideoxyadenosine and 8‐Mercapto‐2′,3′‐Dideoxyinosine

Bulletin des sociétés chimiques belges, 1991, Vol.100 (2), p.183-184

1991

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5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

Nucleosides & nucleotides, 1991-01, Vol.10 (1-3), p.585-586

1991

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3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-triazol-1-yl)-2′,3′-dideoxyuridine

Journal of heterocyclic chemistry, 1989-11, Vol.26 (6), p.1635-1642

1989

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Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor

THU0236 Once-Daily Dosing of GLPG0634, a Selective JAK1 Inhibitor, is Supported by Its Active Metabolite

Stereoselective and Efficient Synthesis of (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

OP0263 Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial

GLPG0187 inhibits progression of established bone metastasis and achieves maximum efficacy when combined with standard-of-care metastatic breast cancer treatments

PP 87 Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models

TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors of HIV-1 Integrase

Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus

Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus

Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

Synthesis of thymidine from 5-iodo-2′-deoxyuridine

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2′-Deoxyuridine

2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation

Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogs

Synthesis of Thymidine Analogues with a Cyanoimido Substituent

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines

Synthesis of 8‐Mercapto‐2′,3′‐Dideoxyadenosine and 8‐Mercapto‐2′,3′‐Dideoxyinosine

5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-triazol-1-yl)-2′,3′-dideoxyuridine

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