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Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable--Case Studies for Critical Thinking

1, 2023

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Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4

Molecular pharmacology, 2014-12, Vol.86 (6), p.665-674

2014

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Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture

Drug metabolism and disposition, 2011-08, Vol.39 (8), p.1415-1422

2011

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Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

Drug metabolism and disposition, 2010-06, Vol.38 (6), p.981-987

2010

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Effects of interleukin 1β (IL-1β) and IL-1β/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture

Current drug metabolism, 2012-09, Vol.13 (7), p.930-937

2012

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Beyond cytotoxic potency: disposition features required to design ADC payload

Xenobiotica, 2024-09, Vol.54 (8), p.442-457

2024

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Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.47-53

2012

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Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1546-1554

2011

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Handbook of Drug Metabolism, Third Edition

3, 2019

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Handbook of Drug Metabolism

Third edition, 2019

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Characterization of the active site properties of CYP4F12

Drug metabolism and disposition, 2014-10, Vol.42 (10), p.1698-1707

2014

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Predicting in vivo drug interactions from in vitro drug discovery data

Nature reviews. Drug discovery, 2005-10, Vol.4 (10), p.825-833

2005

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Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction

Drug metabolism and disposition, 2011-07, Vol.39 (7), p.1188-1195

2011

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Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes

Archives of biochemistry and biophysics, 2013-07, Vol.535 (2), p.143-149

2013

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Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression

Biochemical pharmacology, 2012-06, Vol.83 (12), p.1682-1689

2012

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Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

Drug metabolism and disposition, 2020-06, Vol.48 (6), p.508-514

2020

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In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract

Drug metabolism and disposition, 2009-09, Vol.37 (9), p.1848-1855

2009

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The in vitro drug interaction potential of dietary supplements containing multiple herbal components

Drug metabolism and disposition, 2007-02, Vol.35 (2), p.185-188

2007

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Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates

Chemical research in toxicology, 2007-12, Vol.20 (12), p.1778-1786

2007

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In vitro metabolism of clindamycin in human liver and intestinal microsomes

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.878-887

2003

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Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1906-1913

2014

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Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

Archives of biochemistry and biophysics, 2003-02, Vol.410 (1), p.16-24

2003

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In vitro characterization of the drug-drug interaction potential of catabolites of antibody-maytansinoid conjugates

Drug metabolism and disposition, 2012-10, Vol.40 (10), p.1927-1934

2012

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Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1523-1529

2006

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Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

Drug metabolism and disposition, 2001-01, Vol.29 (1), p.70

2001

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Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable--Case Studies for Critical Thinking

Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4

Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture

Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

Effects of interleukin 1β (IL-1β) and IL-1β/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture

Beyond cytotoxic potency: disposition features required to design ADC payload

Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition

Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate

Handbook of Drug Metabolism, Third Edition

Handbook of Drug Metabolism

Characterization of the active site properties of CYP4F12

Predicting in vivo drug interactions from in vitro drug discovery data

Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction

Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes

Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression

Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract

The in vitro drug interaction potential of dietary supplements containing multiple herbal components

Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates

In vitro metabolism of clindamycin in human liver and intestinal microsomes

Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

In vitro characterization of the drug-drug interaction potential of catabolites of antibody-maytansinoid conjugates

Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine

Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

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