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Osteoarthritis - an untreatable disease?

Nature reviews. Drug discovery, 2005-04, Vol.4 (4), p.331-344

2005

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Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices

European journal of pharmacology, 2000-09, Vol.404 (1-2), p.133-136

2000

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BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist

European journal of pharmacology, 1999-11, Vol.384 (2-3), p.R3-R5

1999

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Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies

Molecules (Basel, Switzerland), 2001-05, Vol.6 (5), p.448-467

2001

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The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist : BIBP3226

European journal of pharmacology, 1994-12, Vol.271 (2-3), p.R11-R13

1994

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The SK‐N‐MC cell line expresses an orexin binding site different from recombinant orexin 1‐type receptor

European journal of biochemistry, 2002-02, Vol.269 (4), p.1128-1135

2002

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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

Journal of medicinal chemistry, 1994-12, Vol.37 (26), p.4576-4580

1994

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BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: A review of its pharmacological properties

Regulatory peptides, 1996-08, Vol.65 (1), p.71-77

1996

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Ala31-Aib32: Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y5-Receptor

Biochemistry (Easton), 2002-06, Vol.41 (25), p.8043-8049

2002

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Validation of a diffusion chamber as in vitro system for the analysis of compound diffusibility through cartilage tissue

Biomedicine & pharmacotherapy, 2005-08, Vol.59 (7), p.395-401

2005

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Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus

Regulatory peptides, 2003-03, Vol.111 (1), p.21-29

2003

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Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor

FEBS letters, 1996-09, Vol.394 (2), p.169-173

1996

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The First Selective Agonist for the Neuropeptide YY5Receptor Increases Food Intake in Rats

The Journal of biological chemistry, 2000-11, Vol.275 (46), p.36043-36048

2000

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Divalent cations influencing neuropeptide Y receptor subtype binding in rat hippocampus and cortex membranes as well as in recombinant cells

Regulatory peptides, 1998-09, Vol.75, p.263-269

1998

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A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

The Journal of biological chemistry, 1992-01, Vol.267 (3), p.1426-1429

1992

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A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor

Journal of peptide science, 1995-09, Vol.1 (5), p.341-348

1995

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Adrenomedullin mediates vasodilation via CGRP1 receptors

Life sciences (1973), 1994-11, Vol.56 (1), p.PL19-PL25

1994

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Y-receptor affinity modulation by the design of pancreatic polypeptide/neuropeptide Y chimera led to Y5-receptor ligands with picomolar affinity

Peptides (New York, N.Y. : 1980), 2001-03, Vol.22 (3), p.365-378

2001

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The role of NPY in metabolic homeostasis: implications for obesity therapy

Expert opinion on investigational drugs, 2000-06, Vol.9 (6), p.1327-1346

2000

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Y-receptor affinity modulation by the design of pancreatic polypeptide/neuropeptide Y chimera led to Y 5-receptor ligands with picomolar affinity

Peptides (New York, N.Y. : 1980), 2001-03, Vol.22 (3), p.365-378

2001

Volltextzugriff (PDF)

Ala 31 -Aib 32 : Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y 5 -Receptor

Biochemistry (Easton), 2002-06, Vol.41 (25), p.8043-8049

2002

Volltextzugriff (PDF)

Y1 receptors in the nucleus accumbens: Ultrastructural localization and association with neuropeptide Y

Journal of neuroscience research, 1998-04, Vol.52 (1), p.54-68

1998

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Effects of the neuropeptide Y Y 2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices

European journal of pharmacology, 2000, Vol.404 (1), p.133-136

2000

Volltextzugriff (PDF)

Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y 2 receptor

FEBS letters, 1996-09, Vol.394 (2), p.169-173

1996

Volltextzugriff (PDF)

Approaches in anticoagulation: rationales for target positioning

Current opinion in investigational drugs (London, England : 2000), 2003-03, Vol.4 (3), p.264

2003

Volltextzugriff (PDF)

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Osteoarthritis - an untreatable disease?

Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices

BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist

Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies

The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist : BIBP3226

The SK‐N‐MC cell line expresses an orexin binding site different from recombinant orexin 1‐type receptor

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: A review of its pharmacological properties

Ala31-Aib32: Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y5-Receptor

Validation of a diffusion chamber as in vitro system for the analysis of compound diffusibility through cartilage tissue

Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus

Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor

The First Selective Agonist for the Neuropeptide YY5Receptor Increases Food Intake in Rats

Divalent cations influencing neuropeptide Y receptor subtype binding in rat hippocampus and cortex membranes as well as in recombinant cells

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor

Adrenomedullin mediates vasodilation via CGRP1 receptors

Y-receptor affinity modulation by the design of pancreatic polypeptide/neuropeptide Y chimera led to Y5-receptor ligands with picomolar affinity

The role of NPY in metabolic homeostasis: implications for obesity therapy

Y-receptor affinity modulation by the design of pancreatic polypeptide/neuropeptide Y chimera led to Y 5-receptor ligands with picomolar affinity

Ala 31 -Aib 32 : Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y 5 -Receptor

Y1 receptors in the nucleus accumbens: Ultrastructural localization and association with neuropeptide Y

Effects of the neuropeptide Y Y 2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices

Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y 2 receptor

Approaches in anticoagulation: rationales for target positioning

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