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Potentiating SLC transporter activity: Emerging drug discovery opportunities

Biochemical pharmacology, 2017-07, Vol.135, p.1-11

2017

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T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers

PloS one, 2017-01, Vol.12 (1), p.e0170102-e0170102

2017

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disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (7), p.2758-2763

2014

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Sodium Channel Blockers for the Treatment of Neuropathic Pain

Neurotherapeutics, 2009-10, Vol.6 (4), p.663-678

2009

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The physiology, pharmacology and future of P2X7 as an analgesic drug target: hype or promise?

Current pharmaceutical biotechnology, 2011-10, Vol.12 (10), p.1698

2011

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In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.818

2008

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Activation of TRPA1 by Farnesyl Thiosalicylic Acid

Molecular pharmacology, 2008-04, Vol.73 (4), p.1225-1234

2008

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Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs

The Journal of pharmacology and experimental therapeutics, 2007-11, Vol.323 (2), p.665

2007

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Cardiac-Specific Elevations in Thyroid Hormone Enhance Contractility and Prevent Pressure Overload-Induced Cardiac Dysfunction

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (15), p.6043-6048

2006

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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567

British journal of pharmacology, 2013-10, Vol.170 (3), p.624-640

2013

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Stoichiometry of Expressed KCNQ2/KCNQ3 Potassium Channels and Subunit Composition of Native Ganglionic M Channels Deduced from Block by Tetraethylammonium

The Journal of neuroscience, 2003-06, Vol.23 (12), p.5012-5019

2003

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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

The Journal of pharmacology and experimental therapeutics, 2016-05, Vol.357 (2), p.394

2016

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Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides

Channels (Austin, Tex.), 2021-01, Vol.15 (1), p.193-207

2021

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A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)

The Journal of biological chemistry, 2020-03, Vol.295 (13), p.4359-4366

2020

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

European journal of pharmacology, 2011-08, Vol.663 (1), p.40-50

2011

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The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

Neuroscience letters, 2009-11, Vol.465 (2), p.138-142

2009

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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

Journal of medicinal chemistry, 2017-06, Vol.60 (11), p.4559-4572

2017

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Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties

The Journal of clinical investigation, 2020-11, Vol.130 (11), p.6158-6170

2020

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State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281

Molecular pharmacology, 2016-12, Vol.90 (6), p.766-774

2016

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K + channels as therapeutic drug targets

Pharmacology & therapeutics (Oxford), 2002-04, Vol.94 (1), p.157-182

Wickenden, Alan D

2002

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Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

The Journal of biological chemistry, 2013-08, Vol.288 (31), p.22707-22720

2013

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7

The Journal of biological chemistry, 2020-01, Vol.295 (5), p.1315-1327

2020

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa v 1.7

The Journal of biological chemistry, 2020-01, Vol.295 (5), p.1315-1327

2020

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Recent advances in the biology and medicinal chemistry of TRPA1

Future medicinal chemistry, 2010-05, Vol.2 (5), p.843-858

2010

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Overview of Electrophysiological Techniques

Current Protocols in Pharmacology, 2014-03, Vol.11 (1), p.11.1.1-11.1.17

Wickenden, Alan D.

2014

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Potentiating SLC transporter activity: Emerging drug discovery opportunities

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers

disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ

Sodium Channel Blockers for the Treatment of Neuropathic Pain

The physiology, pharmacology and future of P2X7 as an analgesic drug target: hype or promise?

In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

Activation of TRPA1 by Farnesyl Thiosalicylic Acid

Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs

Cardiac-Specific Elevations in Thyroid Hormone Enhance Contractility and Prevent Pressure Overload-Induced Cardiac Dysfunction

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567

Stoichiometry of Expressed KCNQ2/KCNQ3 Potassium Channels and Subunit Composition of Native Ganglionic M Channels Deduced from Block by Tetraethylammonium

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides

A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties

State-Dependent Allosteric Inhibition of the Human SLC13A5 Citrate Transporter by Hydroxysuccinic Acids, PF-06649298 and PF-06761281

K + channels as therapeutic drug targets

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7

Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa v 1.7

Recent advances in the biology and medicinal chemistry of TRPA1

Overview of Electrophysiological Techniques

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