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Covalent hits and where to find them

SLAS discovery, 2024-04, Vol.29 (3), p.100142, Article 100142

2024

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Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine

Organic letters, 2016-04, Vol.18 (7), p.1694-1697

2016

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Put a ring on it: application of small aliphatic rings in medicinal chemistry

RSC medicinal chemistry, 2021-04, Vol.12 (4), p.448-471

2021

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C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes

mSphere, 2018-01, Vol.3 (1)

2018

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Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery

Journal of medicinal chemistry, 2023-06, Vol.66 (11), p.7594-7604

2023

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P143 Evaluation of a pharmacist led severe asthma medicines optimisation clinic

Thorax, 2022-11, Vol.77 (Suppl 1), p.A158-A158

2022

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Hit me with your best shot: Integrated hit discovery for the next generation of drug targets

Drug discovery today, 2024-10, Vol.29 (10), p.104143, Article 104143

2024

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Identification of 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamides as a novel class of potent DprE1 inhibitors

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (12), p.127192-127192, Article 127192

2020

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Mycobacterium tuberculosis Decaprenylphosphoryl-β‑d‑ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2557-2576

2020

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Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy

British journal of dermatology (1951), 2000-10, Vol.143 (4), p.767-772

2000

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4.56 Exploring Countertransference Through Film

Journal of the American Academy of Child and Adolescent Psychiatry, 2018-10, Vol.57 (10), p.S222-S222

2018

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M24 3-year real world outcomes with benralizumab for severe eosinophilic asthma

Thorax, 2023-11, Vol.78 (Suppl 4), p.A274-A275

2023

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An open study to determine the efficacy of blue light in the treatment of mild to moderate acne

The Journal of dermatological treatment, 2005, Vol.16 (4), p.219-223

2005

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Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway

Molecular medicine (Cambridge, Mass.), 1994-11, Vol.1 (1), p.93-103

1994

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Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter

Immunity (Cambridge, Mass.), 1999-03, Vol.10 (3), p.313-322

1999

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Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease

British journal of dermatology (1951), 1996-11, Vol.135 (5), p.766-771

1996

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Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy

British journal of dermatology (1951), 2000-12, Vol.143 (6), p.1270-1275

2000

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Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine

Organic letters, 2016-05, Vol.18 (9), p.2326-2326

2016

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Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms

Immunity (Cambridge, Mass.), 2000-11, Vol.13 (5), p.703-714

2000

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MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells

The Journal of immunology (1950), 1996-02, Vol.156 (3), p.1020-1029

1996

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Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth

Virology (New York, N.Y.), 2006-03, Vol.347 (1), p.199-207

2006

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Photodynamic therapy for superficial bladder cancer under local anaesthetic

BJU international, 2002-05, Vol.89 (7), p.665-670

2002

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A Nuclear Matrix Attachment Region Upstream of the T Cell Receptor β Gene Enhancer Binds Cux/CDP and SATB1 and Modulates Enhancer-dependent Reporter Gene Expression but Not Endogenous Gene Expression

The Journal of biological chemistry, 1998-11, Vol.273 (45), p.29838-29846

1998

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Light penetration in bladder tissue: implications for the intravesical photodynamic therapy of bladder tumours

BJU international, 2000-10, Vol.86 (6), p.638-643

2000

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Photodynamic treatment for lower genital tract intraepithelial neoplasia

The Lancet (British edition), 1998-05, Vol.351 (9113), p.1403-1403

1998

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Covalent hits and where to find them

Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine

Put a ring on it: application of small aliphatic rings in medicinal chemistry

C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes

Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery

P143 Evaluation of a pharmacist led severe asthma medicines optimisation clinic

Hit me with your best shot: Integrated hit discovery for the next generation of drug targets

Identification of 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamides as a novel class of potent DprE1 inhibitors

Mycobacterium tuberculosis Decaprenylphosphoryl-β‑d‑ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity

Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy

4.56 Exploring Countertransference Through Film

M24 3-year real world outcomes with benralizumab for severe eosinophilic asthma

An open study to determine the efficacy of blue light in the treatment of mild to moderate acne

Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway

Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter

Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease

Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy

Chemoselective Sequential Click Ligations Directed by Enhanced Reactivity of an Aromatic Ynamine

Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms

MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells

Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth

Photodynamic therapy for superficial bladder cancer under local anaesthetic

A Nuclear Matrix Attachment Region Upstream of the T Cell Receptor β Gene Enhancer Binds Cux/CDP and SATB1 and Modulates Enhancer-dependent Reporter Gene Expression but Not Endogenous Gene Expression

Light penetration in bladder tissue: implications for the intravesical photodynamic therapy of bladder tumours

Photodynamic treatment for lower genital tract intraepithelial neoplasia

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