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Applications of accelerator mass spectrometry for pharmacological and toxicological research

Mass spectrometry reviews, 2006-01, Vol.25 (1), p.127-145

2006

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Adenomyosis—A Result of Disordered Stromal Differentiation

The American journal of pathology, 2001-08, Vol.159 (2), p.623-630

2001

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Anti-oestrogenic drugs and endometrial cancers

Toxicology letters, 2000-07, Vol.116 (1-2), p.21-29

2000

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Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans

Current drug metabolism, 2003-06, Vol.4 (3), p.223-239

White, I N H

2003

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Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA

Carcinogenesis (New York), 2002-11, Vol.23 (11), p.1897-1902

2002

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Activation of Transcription by Estrogen Receptor α and β Is Cell Type- and Promoter-dependent

The Journal of biological chemistry, 1999-11, Vol.274 (45), p.32008-32014

1999

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Techniques: The application of accelerator mass spectrometry to pharmacology and toxicology

Trends in pharmacological sciences (Regular ed.), 2004-08, Vol.25 (8), p.442-447

2004

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The tamoxifen dilemma

Carcinogenesis (New York), 1999-07, Vol.20 (7), p.1153-1160

WHITE, I. N. H

1999

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Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry

Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8461-8465

2003

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Influence of oestradiol and tamoxifen on oestrogen receptors-α and -β protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells

Journal of molecular endocrinology, 2005-12, Vol.35 (3), p.421-432

2005

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Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

Carcinogenesis (New York), 1992-12, Vol.13 (12), p.2197-2203

1992

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Anti-oestrogenic drugs and endometrial cancers

Toxicology letters, 2001-03, Vol.120 (1), p.21-29

White, Ian N.H.

2001

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Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of α-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen–DNA adducts

Carcinogenesis (New York), 2000-10, Vol.21 (10), p.1851-1858

2000

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Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia

Carcinogenesis (New York), 2000-04, Vol.21 (4), p.793-797

2000

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Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2005-03, Vol.56 (4), p.255-263

2005

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α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

Carcinogenesis (New York), 1999-01, Vol.20 (1), p.153-160

1999

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Chemoprevention of Breast Cancer by Tamoxifen: Risks and Opportunities

Critical reviews in toxicology, 2000-01, Vol.30 (5), p.571-594

2000

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Tamoxifen causes gene mutations in the livers of Lambda/lacI transgenic rats

Cancer research (Chicago, Ill.), 1997-04, Vol.57 (7), p.1288-1293

1997

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Comparison of the effect of oestradiol, tamoxifen and raloxifene on nerve growth factor-alpha expression in specific neonatal mouse uterine cell types using laser capture microdissection

Journal of molecular endocrinology, 2003-02, Vol.30 (1), p.1-11

2003

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The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons

Toxicology letters, 2001-10, Vol.124 (1), p.121-128

2001

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A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes

Carcinogenesis (New York), 1994-04, Vol.15 (4), p.589-593

1994

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Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N,N-didesmethyltamoxifen

Carcinogenesis (New York), 1999-10, Vol.20 (10), p.2011-2016

1999

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Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

Carcinogenesis (New York), 1994, Vol.15 (1), p.5-9

1994

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Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats : promotion by phenobarbital

Cancer research (Chicago, Ill.), 1995-02, Vol.55 (3), p.544-547

1995

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Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells

Toxicology letters, 2001-10, Vol.124 (1-3), p.129-138

2001

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Applications of accelerator mass spectrometry for pharmacological and toxicological research

Adenomyosis—A Result of Disordered Stromal Differentiation

Anti-oestrogenic drugs and endometrial cancers

Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans

Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA

Activation of Transcription by Estrogen Receptor α and β Is Cell Type- and Promoter-dependent

Techniques: The application of accelerator mass spectrometry to pharmacology and toxicology

The tamoxifen dilemma

Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry

Influence of oestradiol and tamoxifen on oestrogen receptors-α and -β protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

Anti-oestrogenic drugs and endometrial cancers

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of α-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen–DNA adducts

Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia

Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer

α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

Chemoprevention of Breast Cancer by Tamoxifen: Risks and Opportunities

Tamoxifen causes gene mutations in the livers of Lambda/lacI transgenic rats

Comparison of the effect of oestradiol, tamoxifen and raloxifene on nerve growth factor-alpha expression in specific neonatal mouse uterine cell types using laser capture microdissection

The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons

A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes

Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N,N-didesmethyltamoxifen

Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats : promotion by phenobarbital

Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells

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