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C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization

Current biology, 2020-07, Vol.30 (14), p.2695-2706.e4

2020

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Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits

Journal of thrombosis and haemostasis, 2022-02, Vol.20 (2), p.399-408

2022

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The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence

BMC biology, 2019-12, Vol.17 (1), p.100-100, Article 100

2019

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Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

Journal of thrombosis and haemostasis, 2008-05, Vol.6 (5), p.820-829

2008

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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5339-5356

2007

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Factor Xa Inhibitors: Next-Generation Antithrombotic Agents

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6243-6274

2010

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Pan-metazoan phylogeny of the DMRT gene family: a framework for functional studies

Development genes and evolution, 2014-06, Vol.224 (3), p.175-181

2014

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9703-9723

2017

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1729-1744

2005

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The Prevalence of Huntington's Disease

Neuroepidemiology, 2016-03, Vol.46 (2), p.144-153

2016

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In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa

Journal of thrombosis and thrombolysis, 2015-11, Vol.40 (4), p.416-423

2015

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Involvement of endothelial PECAM-1/CD31 in angiogenesis

The American journal of pathology, 1997-09, Vol.151 (3), p.671-677

1997

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Huntington’s and the History of Sleep

Journal of Huntington's disease, 2023-01, Vol.12 (2), p.167-168

2023

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Transformation of Anionically Activated Trifluoromethyl Groups to Heterocycles under Mild Aqueous Conditions

Organic letters, 2011-04, Vol.13 (7), p.1804-1807

2011

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Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.625-656

1996

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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2001-02, Vol.44 (4), p.566-578

2001

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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1770-1785

2022

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Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (8), p.2432-2435

2013

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Advances in genome sequencing reveal changes in gene content that contribute to arthropod macroevolution

Development genes and evolution, 2023-12, Vol.233 (2), p.59-76

2023

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Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9010-9026

2015

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Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

Science translational medicine, 2017-01, Vol.9 (371)

2017

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Experimental Entomology in the Age of Video

Journal of visualized experiments, 2023-02 (192)

2023

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Dynamic, Non-binary Specification of Sexual State in the C. elegans Nervous System

Current biology, 2020-09, Vol.30 (18), p.3617-3623.e3

2020

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Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor

European journal of drug metabolism and pharmacokinetics, 2011-09, Vol.36 (3), p.129-139

2011

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C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization

Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits

The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence

Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Factor Xa Inhibitors: Next-Generation Antithrombotic Agents

Pan-metazoan phylogeny of the DMRT gene family: a framework for functional studies

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

The Prevalence of Huntington's Disease

In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa

Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist

Involvement of endothelial PECAM-1/CD31 in angiogenesis

Huntington’s and the History of Sleep

Transformation of Anionically Activated Trifluoromethyl Groups to Heterocycles under Mild Aqueous Conditions

Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

Advances in genome sequencing reveal changes in gene content that contribute to arthropod macroevolution

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

Experimental Entomology in the Age of Video

Dynamic, Non-binary Specification of Sexual State in the C. elegans Nervous System

Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor

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