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Successful treatment of a PNH patient non‐responsive to eculizumab with the novel complement C5 inhibitor coversin (nomacopan)

British journal of haematology, 2020-01, Vol.188 (2), p.334-337

2020

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Allergic eye disease: Blocking LTB4/C5 in vivo suppressed disease and Th2 & Th9 cells

Allergy (Copenhagen), 2022-02, Vol.77 (2), p.660-664

2022

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Dual inhibition of complement component 5 and leukotriene B4 by topical rVA576 in atopic keratoconjunctivis: TRACKER phase 1 clinical trial results

Orphanet journal of rare diseases, 2021-06, Vol.16 (1), p.270-270, Article 270

2021

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Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning

Frontiers in immunology, 2023-09, Vol.14, p.1192765-1192765

2023

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Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury

PloS one, 2013-05, Vol.8 (5), p.e64443-e64443

2013

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Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis

Cells (Basel, Switzerland), 2021-02, Vol.10 (2), p.396

2021

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Complement C5 inhibition attenuates lung inflammation in H1N1 influenza

Molecular immunology, 2010-08, Vol.47 (13), p.2252-2252

2010

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Histamine Scavenging Attenuates Endotoxin-Induced Acute Lung Injury

Annals of the New York Academy of Sciences, 2005-11, Vol.1056 (1), p.197-205

2005

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Arthropod-Derived Protein EV131 Inhibits Histamine Action and Allergic Asthma

Annals of the New York Academy of Sciences, 2005-11, Vol.1056 (1), p.189-196

2005

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Long Term Nomacopan Administration Results in Complete Transfusion Independence in Previously Transfusion-Dependent PNH Patients

Blood, 2019-11, Vol.134 (Supplement_1), p.4797-4797

2019

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Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues

The American journal of pathology, 2021-02, Vol.191 (2), p.320-334

2021

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Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells

The American journal of pathology, 2021-02, Vol.191 (2), p.320-334

2021

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Coversin, a Novel C5 Complement Inhibitor, Is Safe and Effective in the Treatment of PNH: Results of a Phase II Clinical Trial

Blood, 2017-12, Vol.130, p.4747-4747

2017

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C5 Polymorphism in a Dutch Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH) and No Asian Ancestry, Resistant to Eculizumab, but in Vitro Sensitive to Coversin

Blood, 2015-12, Vol.126 (23), p.1209-1209

2015

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Coversin Blocked in Vitro Hemolysis in an Eculizumab-Resistant PNH Patient with the C5 Polymorphism (c.2654G>A)

Blood, 2015-12, Vol.126 (23), p.2138-2138

2015

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Leukotriene B 4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB 4 Dependence of Retinal Th17 Cells

The American journal of pathology, 2021-02, Vol.191 (2), p.320

2021

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Arthropod-Derived Histamine-Binding Protein Prevents Murine Allergic Asthma

The Journal of immunology (1950), 2004-09, Vol.173 (5), p.3281-3286

2004

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Clinical and Immunological Characterisation of Coversin, a Novel Small Protein Inhibitor of Complement C5 with Potential As a Therapeutic Agent in PNH and Other Complement Mediated Disorders

Blood, 2014-12, Vol.124 (21), p.4280-4280

2014

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Coversin is effective in the treatment of PNH with resistance to eculizumab due to complement C5 polymorphism

Immunobiology (1979), 2016-10, Vol.221 (10), p.1213-1213

2016

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Parasite saliva as a source of antiallergic agents

The Lancet (British edition), 2002-03, Vol.359 (9311), p.1067-1067

2002

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Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury. e64443

PloS one, 2013-05, Vol.8 (5)

2013

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Evaluating general practitioner services

BMJ, 1989-09, Vol.299 (6702), p.794-794

Weston-Davies, W.

1989

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Successful treatment of a PNH patient non‐responsive to eculizumab with the novel complement C5 inhibitor coversin (nomacopan)

Allergic eye disease: Blocking LTB4/C5 in vivo suppressed disease and Th2 & Th9 cells

Dual inhibition of complement component 5 and leukotriene B4 by topical rVA576 in atopic keratoconjunctivis: TRACKER phase 1 clinical trial results

Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning

Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury

Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis

Complement C5 inhibition attenuates lung inflammation in H1N1 influenza

Histamine Scavenging Attenuates Endotoxin-Induced Acute Lung Injury

Arthropod-Derived Protein EV131 Inhibits Histamine Action and Allergic Asthma

Long Term Nomacopan Administration Results in Complete Transfusion Independence in Previously Transfusion-Dependent PNH Patients

Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues

Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells

Coversin, a Novel C5 Complement Inhibitor, Is Safe and Effective in the Treatment of PNH: Results of a Phase II Clinical Trial

C5 Polymorphism in a Dutch Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH) and No Asian Ancestry, Resistant to Eculizumab, but in Vitro Sensitive to Coversin

Coversin Blocked in Vitro Hemolysis in an Eculizumab-Resistant PNH Patient with the C5 Polymorphism (c.2654G>A)

Leukotriene B 4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB 4 Dependence of Retinal Th17 Cells

Arthropod-Derived Histamine-Binding Protein Prevents Murine Allergic Asthma

Clinical and Immunological Characterisation of Coversin, a Novel Small Protein Inhibitor of Complement C5 with Potential As a Therapeutic Agent in PNH and Other Complement Mediated Disorders

Coversin is effective in the treatment of PNH with resistance to eculizumab due to complement C5 polymorphism

Parasite saliva as a source of antiallergic agents

Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury. e64443

Evaluating general practitioner services

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