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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Nature communications, 2020-06, Vol.11 (1), p.2739-2739, Article 2739

2020

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Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

Nature biotechnology, 2018-10, Vol.36 (9), p.857-864

2018

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Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis

Science signaling, 2009-06, Vol.2 (77), p.ra31

2009

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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

The Journal of clinical investigation, 2003-01, Vol.111 (1), p.81-90

2003

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

Drug Resistance Updates, 2002-12, Vol.5 (6), p.234-248

2002

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Metabolic modulation of tumours with engineered bacteria for immunotherapy

Nature (London), 2021-10, Vol.598 (7882), p.662-666

2021

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HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer

PloS one, 2014-12, Vol.9 (12), p.e115228-e115228

2014

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An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Science translational medicine, 2019-01, Vol.11 (475)

2019

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Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer

Molecular cancer therapeutics, 2011-05, Vol.10 (5), p.817-824

2011

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Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway

Molecular biology of the cell, 2002-05, Vol.13 (5), p.1550-1565

2002

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Nature chemical biology, 2015-06, Vol.11 (6), p.432-437

2015

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Hedgehog-Gli Pathway Activation during Kidney Fibrosis

The American journal of pathology, 2012-04, Vol.180 (4), p.1441-1453

2012

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Inhibition of the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy

Cancer research (Chicago, Ill.), 2005-09, Vol.65 (18), p.8423-8432

2005

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Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo

The Journal of biological chemistry, 2010-12, Vol.285 (51), p.39835-39843

2010

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Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance

Cancer research (Chicago, Ill.), 2003-02, Vol.63 (4), p.780-786

2003

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Starting with the ABCs: Akt in breast cancer

Molecular cancer therapeutics, 2011-11, Vol.10 (11), p.2031-2031

2011

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Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo

Cancer research (Chicago, Ill.), 2004-01, Vol.64 (2), p.446-451

2004

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Preferential inhibition of Akt and killing of akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues

Cancer research (Chicago, Ill.), 2004-04, Vol.64 (8), p.2782-2792

2004

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Paxillin–ARF GAP signaling and the cytoskeleton

Current Opinion in Cell Biology, 2001-10, Vol.13 (5), p.593-599

2001

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The LD4 Motif of Paxillin Regulates Cell Spreading and Motility through an Interaction with Paxillin Kinase Linker (PKL)

The Journal of cell biology, 2001-07, Vol.154 (1), p.161-176

2001

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BOS-371, a monoclonal antibody against IL1RAP: Characterization in preclinical models of AML

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.7030-7030

2023

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Tobacco Carcinogen-Induced Cellular Transformation Increases Akt Activation In Vitro and In Vivo

Chest, 2004-05, Vol.125 (5), p.101S-102S

2004

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Abstract 2920: Metabolic modulation of the tumor microenvironment using Synthetic Biotic™ Medicines

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2920-2920

2018

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Abstract 2827: Activity of the proprietary Hsp90 inhibitor IPI-493 in models of colorectal cancer correlates with RAS pathway activation

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2827-2827

2011

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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

Activation of the PI3K/Akt pathway and chemotherapeutic resistance

Metabolic modulation of tumours with engineered bacteria for immunotherapy

HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer

Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

Inhibition of the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy

Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance

Starting with the ABCs: Akt in breast cancer

Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo

Preferential inhibition of Akt and killing of akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues

Paxillin–ARF GAP signaling and the cytoskeleton

The LD4 Motif of Paxillin Regulates Cell Spreading and Motility through an Interaction with Paxillin Kinase Linker (PKL)

BOS-371, a monoclonal antibody against IL1RAP: Characterization in preclinical models of AML

Tobacco Carcinogen-Induced Cellular Transformation Increases Akt Activation In Vitro and In Vivo

Abstract 2920: Metabolic modulation of the tumor microenvironment using Synthetic Biotic™ Medicines

Abstract 2827: Activity of the proprietary Hsp90 inhibitor IPI-493 in models of colorectal cancer correlates with RAS pathway activation

Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma

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