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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Archives of toxicology, 2020-09, Vol.94 (9), p.3281-3295

2020

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Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

Archives of toxicology, 2022-01, Vol.96 (1), p.135-151

2022

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In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

Chemico-biological interactions, 2020-01, Vol.315, p.108905-108905, Article 108905

2020

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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Archives of toxicology, 2022-05, Vol.96 (5), p.1387-1409

2022

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Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Archives of toxicology, 2021-05, Vol.95 (5), p.1573-1593

2021

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Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

Frontiers in pharmacology, 2023-03, Vol.14, p.1125146-1125146

2023

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Occurrence and Probabilistic Risk Assessment of Fumonisin B1, Fumonisin B2 and Deoxynivalenol in Nixtamalized Maize in Mexico City

Toxins, 2020-10, Vol.12 (10), p.644

2020

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Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

Archives of toxicology, 2020-04, Vol.94 (4), p.1349-1365

2020

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In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Current research in toxicology, 2024-01, Vol.6, p.100160-100160, Article 100160

2024

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Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in nutmeg‐based plant food supplements

Journal of applied toxicology, 2017-10, Vol.37 (10), p.1254-1264

2017

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On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin

Antioxidants, 2023-08, Vol.12 (8), p.1544

2023

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Aflatoxin B1 in nixtamalized maize in Mexico; occurrence and accompanying risk assessment

Toxicology reports, 2019-01, Vol.6, p.1135-1142

2019

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Salt sensitivity of blood pressure: developmental and sex-related effects

The American journal of clinical nutrition, 2011-12, Vol.94 (6S), p.S1928-S1932

2011

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Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

BMC complementary medicine and therapies, 2020-03, Vol.20 (1), p.80-80, Article 80

2020

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Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto

Toxicology reports, 2017, Vol.4, p.1-8

2017

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Short-term erythropoietin treatment does not substantially modulate monocyte transcriptomes of patients with combined heart and renal failure

PloS one, 2012-09, Vol.7 (9), p.e41339-e41339

2012

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Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Molecular nutrition & food research, 2023-02, Vol.67 (4), p.n/a

2023

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Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

Toxicology letters, 2023-10, Vol.388, p.30-39

2023

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Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

Environmental science & technology, 2024-02, Vol.58 (7), p.3129-3140

2024

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Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Food and chemical toxicology, 2019-03, Vol.125, p.467-478

2019

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Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans

Environmental science & technology, 2023-08, Vol.57 (30), p.10974-10984

2023

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A New Approach Methodology Ibogaine-Induced Cardiotoxicity in Humans

ALTEX, alternatives to animal experimentation, 2021-09, Vol.38 (4), p.636

2021

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Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

Toxicology letters, 2021-06, Vol.343, p.34-43

2021

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Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Molecular nutrition & food research, 2023-02, Vol.67 (4), p.e2200293-n/a

2023

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Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

Molecular nutrition & food research, 2020-07, Vol.64 (13), p.e2000063-n/a

2020

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Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent

In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

Occurrence and Probabilistic Risk Assessment of Fumonisin B1, Fumonisin B2 and Deoxynivalenol in Nixtamalized Maize in Mexico City

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in nutmeg‐based plant food supplements

On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin

Aflatoxin B1 in nixtamalized maize in Mexico; occurrence and accompanying risk assessment

Salt sensitivity of blood pressure: developmental and sex-related effects

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto

Short-term erythropoietin treatment does not substantially modulate monocyte transcriptomes of patients with combined heart and renal failure

Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

Toxicokinetics of the Antidepressant Fluoxetine and Its Active Metabolite Norfluoxetine in Caenorhabditis elegans and Their Comparative Potency

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans

A New Approach Methodology Ibogaine-Induced Cardiotoxicity in Humans

Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro–In Silico Testing Strategy

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