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Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Bone (New York, N.Y.), 2006-02, Vol.38 (2), p.234-243

2006

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Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

Bone (New York, N.Y.), 2012-06, Vol.50 (6), p.1250-1259

2012

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Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis

Molecular cancer therapeutics, 2014-12, Vol.13 (12), p.2898-2909

2014

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Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

Journal of bone and mineral research, 2012-03, Vol.27 (3), p.509-523

2012

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Preclinical evaluation of [11C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone

Journal of labelled compounds & radiopharmaceuticals, 2021-04, Vol.64 (4), p.159-167

2021

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Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics

Journal of the American Chemical Society, 2015-09, Vol.137 (35), p.11230-11233

2015

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The role of subchondral bone remodeling in osteoarthritis: Reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

Arthritis and rheumatism, 2004-04, Vol.50 (4), p.1193-1206

2004

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P6. Anti-resorptive and potential anti-invasion effects of a cathepsin K inhibitor in the treatment of breast cancer-induced bone metastasis

Cancer treatment reviews, 2008, Vol.34, p.14-14

2008

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Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.25-29

2002

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Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse

Arthritis and rheumatism, 2007-09, Vol.56 (9), p.2999-3009

2007

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Nonpeptide αvβ3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent αvβ3 Antagonists for the Prevention and Treatment of Osteoporosis

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4829-4837

2004

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M-CSF induces the stable interaction of cFms with αVβ3 integrin in osteoclasts

The international journal of biochemistry & cell biology, 2006-01, Vol.38 (9), p.1518-1529

2006

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M-CSF induces the stable interaction of cFms with α Vβ 3 integrin in osteoclasts

The international journal of biochemistry & cell biology, 2006, Vol.38 (9), p.1518-1529

2006

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M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts

The international journal of biochemistry & cell biology, 2006, Vol.38 (9), p.1518

2006

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Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.25

2002

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Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4829

2004

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Nonpeptide α v β 3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent α v β 3 Antagonists for the Prevention and Treatment of Osteoporosis

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4829-4837

2004

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Nonpeptide α vβ 3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

Bioorganic & medicinal chemistry letters, 2002, Vol.12 (1), p.25-29

2002

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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.923-928

2008

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Datacenter-Scale Analysis and Optimization of GPU Machine Learning Workloads

IEEE MICRO, 2021-09, Vol.41 (5), p.101-112

2021

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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis

Bioorganic & medicinal chemistry letters, 2022-10, Vol.74, p.128927-128927, Article 128927

2022

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Suppression of cathepsin K biomarker in synovial fluid as a free-drug–driven process

Journal of circulating biomarkers, 2019-01, Vol.8, p.1849454418821819-1849454418821819

2019

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Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis

Naunyn-Schmiedeberg's archives of pharmacology, 2017-04, Vol.390 (4), p.435-441

2017

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A Novel Class of Nonpeptidic Biaryl Inhibitors of Human Cathepsin K

Journal of medicinal chemistry, 2003-08, Vol.46 (17), p.3709-3727

2003

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Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

Preclinical evaluation of [11C]L‐235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone

Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics

The role of subchondral bone remodeling in osteoarthritis: Reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

P6. Anti-resorptive and potential anti-invasion effects of a cathepsin K inhibitor in the treatment of breast cancer-induced bone metastasis

Nonpeptide αvβ3 antagonists. Part 2: Constrained glycyl amides derived from the RGD tripeptide

Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse

Nonpeptide αvβ3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent αvβ3 Antagonists for the Prevention and Treatment of Osteoporosis

M-CSF induces the stable interaction of cFms with αVβ3 integrin in osteoclasts

M-CSF induces the stable interaction of cFms with α Vβ 3 integrin in osteoclasts

M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts

Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis

Nonpeptide α v β 3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent α v β 3 Antagonists for the Prevention and Treatment of Osteoporosis

Nonpeptide α vβ 3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Datacenter-Scale Analysis and Optimization of GPU Machine Learning Workloads

Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis

Suppression of cathepsin K biomarker in synovial fluid as a free-drug–driven process

Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis

A Novel Class of Nonpeptidic Biaryl Inhibitors of Human Cathepsin K

Design and Synthesis of Tri-Ring P 3 Benzamide-Containing Aminonitriles as Potent, Selective, Orally Effective Inhibitors of Cathepsin K

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