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Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

BBA - Molecular Cell Research, 2002-11, Vol.1592 (3), p.265-280

2002

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IRAK-4: A Novel Member of the IRAK Family with the Properties of an IRAK-Kinase

Proceedings of the National Academy of Sciences - PNAS, 2002-04, Vol.99 (8), p.5567-5572

2002

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IRAK-4 inhibitors for inflammation

Current topics in medicinal chemistry, 2009-05, Vol.9 (8), p.724

2009

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Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

The Journal of biological chemistry, 1999-06, Vol.274 (25), p.17406-17409

1999

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Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6212-6217

2012

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Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

The Journal of experimental medicine, 1998-12, Vol.188 (11), p.2091-2097

1998

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Sphingosine kinase activity is not required for tumor cell viability

PloS one, 2013-07, Vol.8 (7), p.e68328

2013

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Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

The Journal of biological chemistry, 2004-02, Vol.279 (7), p.5227-5236

2004

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Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.2842-2845

2006

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IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family

The Journal of biological chemistry, 1999-07, Vol.274 (27), p.19403-19410

1999

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Metastatic Properties and Genomic Amplification of the Tyrosine Kinase Gene ACK1

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (44), p.15901-15906

2005

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Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer

PloS one, 2009-05, Vol.4 (5), p.e5722-e5722

2009

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867 TriTAC-XR is an extended-release T cell engager platform designed to minimize cytokine release syndrome by reducing Cmax in systemic circulation

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A908-A908

2021

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T-cell-engaging antibodies for the treatment of solid tumors: challenges and opportunities

Current opinion in oncology, 2022-09, Vol.34 (5), p.552

2022

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632 HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A668-A668

2020

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The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

The Journal of biological chemistry, 1997-03, Vol.272 (12), p.7727-7731

1997

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Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways

PloS one, 2010-09, Vol.5 (9), p.e13024

2010

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The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo

Neoplasia (New York, N.Y.), 2008-04, Vol.10 (4), p.340,IN3-346,IN3

2008

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High throughput screening for protein kinase inhibitors

Combinatorial chemistry & high throughput screening, 2005-03, Vol.8 (2), p.181

2005

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Preclinical Characterization of HPN536, a Trispecific, T-Cell-Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors

Clinical cancer research, 2021-03, Vol.27 (5), p.1452-1462

2021

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Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling

The Journal of biological chemistry, 2002-05, Vol.277 (19), p.16456-16463

2002

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Abstract 913: FLT3-targeting TriTACs are T cell engagers for treatment of acute myeloid leukemia

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.913-913

2021

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Abstract 3814: TriTACs are novel T cell-engaging therapeutic proteins optimized for the treatment of solid tumors and for long serum half-life

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3814-3814

2018

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Abstract 4131: Long-term anti-tumor immunity induced by of HPN328, a DLL3-targeting trispecific, half-life extended T cell engager, in a preclinical immunocompetent mouse model

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.4131-4131

2023

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First-in-human phase I study of HPN424, a tri-specific half-life extended PSMA-targeting T-cell engager in patients with metastatic castration-resistant prostate cancer (mCRPC)

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.5552-5552

2020

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Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

IRAK-4: A Novel Member of the IRAK Family with the Properties of an IRAK-Kinase

IRAK-4 inhibitors for inflammation

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

Sphingosine kinase activity is not required for tumor cell viability

Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family

Metastatic Properties and Genomic Amplification of the Tyrosine Kinase Gene ACK1

Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer

867 TriTAC-XR is an extended-release T cell engager platform designed to minimize cytokine release syndrome by reducing Cmax in systemic circulation

T-cell-engaging antibodies for the treatment of solid tumors: challenges and opportunities

632 HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors

The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways

The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo

High throughput screening for protein kinase inhibitors

Preclinical Characterization of HPN536, a Trispecific, T-Cell-Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors

Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling

Abstract 913: FLT3-targeting TriTACs are T cell engagers for treatment of acute myeloid leukemia

Abstract 3814: TriTACs are novel T cell-engaging therapeutic proteins optimized for the treatment of solid tumors and for long serum half-life

Abstract 4131: Long-term anti-tumor immunity induced by of HPN328, a DLL3-targeting trispecific, half-life extended T cell engager, in a preclinical immunocompetent mouse model

First-in-human phase I study of HPN424, a tri-specific half-life extended PSMA-targeting T-cell engager in patients with metastatic castration-resistant prostate cancer (mCRPC)

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