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Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

Current medicinal chemistry, 2009-11, Vol.16 (32), p.4274-4296

2009

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The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

British journal of pharmacology, 2010-10, Vol.161 (3), p.555-570

2010

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ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (50), p.19881-19886

2008

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Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs . sunflower oil

Clinical nutrition (Edinburgh, Scotland), 2018-04, Vol.37 (2), p.494-504

2018

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Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E 2 synthase‐1

British journal of pharmacology, 2009-03, Vol.156 (6), p.952-961

2009

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Inhibition of microsomal prostaglandin E 2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

British journal of pharmacology, 2011-01, Vol.162 (1), p.147-162

2011

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The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP)

British journal of pharmacology, 2014-06, Vol.171 (12), p.3051-3064

2014

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On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo

British journal of pharmacology, 2012-02, Vol.165 (3), p.765-776

2012

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Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase

British journal of pharmacology, 2014-05, Vol.171 (9), p.2399-2412

2014

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Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin

Planta medica, 2007-10, Vol.73 (13), p.1331-1357

Werz, O

2007

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The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products

British journal of pharmacology, 2007-10, Vol.152 (4), p.471-480

2007

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High capacity for leukotriene biosynthesis in peripheral blood during pregnancy

Prostaglandins, leukotrienes and essential fatty acids, 2013-09, Vol.89 (4), p.245-255

2013

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5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

Biochimica et biophysica acta, 2015-04, Vol.1851 (4), p.331-339

2015

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Long-chain metabolites of α-tocopherol emerge from the shadow of their precursors: Α-13’-OH and Α-13’-COOH as a new class of regulatory metabolites

Atherosclerosis, 2016-09, Vol.252, p.e209-e209

2016

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Valproic acid induces extracellular signal-regulated kinase 1 2 activation and inhibits apoptosis in endothelial cells

Cell death and differentiation, 2006-03, Vol.13 (3), p.446-453

2006

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Upregulation of the 5-lipoxygenase pathway in human monocytes by growth and differentiation factors

Pharmazie, 2013-07, Vol.68 (7), p.578-583

2013

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Long-chain metabolites of vitamin E: A new class of regulatory metabolites modulating atherogenic processes?

Atherosclerosis, 2015-07, Vol.241 (1), p.e82-e83

2015

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Identification of rosmarinic acid as the major active constituent in Cordia americana

Journal of ethnopharmacology, 2010-04, Vol.128 (3), p.561-566

2010

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5-Lipoxygenase: regulation of expression and enzyme activity

Trends in biochemical sciences (Amsterdam. Regular ed.), 2007-07, Vol.32 (7), p.332-341

2007

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Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

The FASEB journal, 2019-05, Vol.33 (5), p.6140-6153

2019

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Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase‐1

British journal of pharmacology, 2009-03, Vol.156 (6), p.952-961

2009

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2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo

British journal of pharmacology, 2011-09, Vol.164 (2b), p.781-793

2011

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Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes

The FASEB journal, 2016-01, Vol.30 (1), p.276-285

2016

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The Atlas of Inflammation Resolution (AIR)

Molecular aspects of medicine, 2020-08, Vol.74, p.100894, Article 100894

2020

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Development of 5-lipoxygenase inhibitors—lessons from cellular enzyme regulation

Biochemical pharmacology, 2005-08, Vol.70 (3), p.327-333

2005

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Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs . sunflower oil

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E 2 synthase‐1

Inhibition of microsomal prostaglandin E 2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP)

On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo

Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase

Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin

The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products

High capacity for leukotriene biosynthesis in peripheral blood during pregnancy

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

Long-chain metabolites of α-tocopherol emerge from the shadow of their precursors: Α-13’-OH and Α-13’-COOH as a new class of regulatory metabolites

Valproic acid induces extracellular signal-regulated kinase 1 2 activation and inhibits apoptosis in endothelial cells

Upregulation of the 5-lipoxygenase pathway in human monocytes by growth and differentiation factors

Long-chain metabolites of vitamin E: A new class of regulatory metabolites modulating atherogenic processes?

Identification of rosmarinic acid as the major active constituent in Cordia americana

5-Lipoxygenase: regulation of expression and enzyme activity

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase‐1

2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo

Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes

The Atlas of Inflammation Resolution (AIR)

Development of 5-lipoxygenase inhibitors—lessons from cellular enzyme regulation

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