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Selective Optimization of Side Activities: Another Way for Drug Discovery

Journal of medicinal chemistry, 2004-03, Vol.47 (6), p.1303-1314

Wermuth, Camille G

2004

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Are pyridazines privileged structures?

MedChemComm, 2011-10, Vol.2 (10), p.935-941

Wermuth, Camille G.

2011

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Design, Synthesis, and Structure−Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2707-2718

2001

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Development of Novel 1,2,3,4-Tetrahydroisoquinoline Derivatives and Closely Related Compounds as Potent and Selective Dopamine D₃ Receptor Ligands

Chembiochem : a European journal of chemical biology, 2004-04, Vol.5 (4), p.508-518

2004

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Selective optimization of side activities: the SOSA approach

Drug discovery today, 2006-02, Vol.11 (3-4), p.160-164

Wermuth, Camille G.

2006

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Practice of Medicinal Chemistry (3rd Edition)

Wermuth, Camille Georges

3rd ed., 2008

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Multitargeted drugs: the end of the ‘one-target-one-disease’ philosophy?

Drug discovery today, 2004-10, Vol.9 (19), p.826-827

Wermuth, Camille G.

2004

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Similarity in drugs: reflections on analogue design

Drug discovery today, 2006-04, Vol.11 (7), p.348-354

Wermuth, Camille G.

2006

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N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands

Journal of medicinal chemistry, 2003-08, Vol.46 (18), p.3883-3899

2003

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Aminopyridazines as Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.730-741

1999

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Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans

Neuromuscular disorders : NMD, 2004-06, Vol.14 (6), p.365-370

2004

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Use of a fluorescent polarization based high throughput assay to identify new Calmodulin ligands

Biochimica et biophysica acta, 2006-11, Vol.1763 (11), p.1250-1255

2006

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Efficient one-step synthesis of 3-amino-6-arylpyridazines

Tetrahedron letters, 2001-03, Vol.42 (11), p.2115-2117

2001

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5-HT3 Antagonists Derived from Aminopyridazine-type Muscarinic M1 Agonists

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.311-317

1998

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Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

Nature (London), 1999-07, Vol.400 (6742), p.371-375

1999

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The Practice of Medicinal Chemistry

Wermuth, Camille Georges

2nd Edition, 2003

Volltextzugriff (PDF)

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase

Journal of medicinal chemistry, 1996-02, Vol.39 (4), p.814-816

1996

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N -(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D 2 and D 3 Receptor Ligands

Journal of medicinal chemistry, 2003-08, Vol.46 (18), p.3883-3899

2003

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errata Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

Nature (London), 1999-09, Vol.401 (6751), p.403-403

1999

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Problèmes et enjeux contemporains de l'innovation thérapeutique

Entreprises et histoire (Paris), 2004-06, Vol.n° 36 (2), p.120-149

2004

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Synthesis of 3-alkynylpyridazines from 3-trifluoromethanesulfonylpyridazines

Heterocycles, 1994-06, Vol.38 (6), p.1273-1286

1994

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Characterization of the Binding of [3H]SR 95531, a GABAA Antagonist, to Rat Brain Membranes

Journal of neurochemistry, 1987-06, Vol.48 (6), p.1677-1686

1987

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Pharmacophores: Historical Perspective and Viewpoint from a Medicinal Chemist

Pharmacophores and Pharmacophore Searches, 2006, p.1-13

2006

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Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors

Journal of computer-aided molecular design, 2001-05, Vol.15 (5), p.395-410

2001

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Analogues as a Means of Discovering New Drugs

Analogue‐based Drug Discovery, 2006, p.1-23

2006

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Selective Optimization of Side Activities: Another Way for Drug Discovery

Are pyridazines privileged structures?

Design, Synthesis, and Structure−Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors

Development of Novel 1,2,3,4-Tetrahydroisoquinoline Derivatives and Closely Related Compounds as Potent and Selective Dopamine D₃ Receptor Ligands

Selective optimization of side activities: the SOSA approach

Practice of Medicinal Chemistry (3rd Edition)

Multitargeted drugs: the end of the ‘one-target-one-disease’ philosophy?

Similarity in drugs: reflections on analogue design

N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands

Aminopyridazines as Acetylcholinesterase Inhibitors

Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans

Use of a fluorescent polarization based high throughput assay to identify new Calmodulin ligands

Efficient one-step synthesis of 3-amino-6-arylpyridazines

5-HT3 Antagonists Derived from Aminopyridazine-type Muscarinic M1 Agonists

Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

The Practice of Medicinal Chemistry

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase

N -(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D 2 and D 3 Receptor Ligands

errata Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

Problèmes et enjeux contemporains de l'innovation thérapeutique

Synthesis of 3-alkynylpyridazines from 3-trifluoromethanesulfonylpyridazines

Characterization of the Binding of [3H]SR 95531, a GABAA Antagonist, to Rat Brain Membranes

Pharmacophores: Historical Perspective and Viewpoint from a Medicinal Chemist

Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors

Analogues as a Means of Discovering New Drugs

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