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The Hexosamine Biosynthesis Pathway: Regulation and Function

Genes, 2023-04, Vol.14 (4), p.933

2023

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Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

Nature communications, 2022-12, Vol.13 (1), p.7404-7404, Article 7404

2022

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MTOR Signaling and Metabolism in Early T Cell Development

Genes, 2021-05, Vol.12 (5), p.728

2021

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mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1

Molecular cell, 2016-09, Vol.63 (5), p.811-826

2016

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Signaling Life and Death in the Thymus: Timing Is Everything

Science (American Association for the Advancement of Science), 2003-03, Vol.299 (5614), p.1859-1863

2003

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Fascin1 promotes cell migration of mature dendritic cells

The Journal of immunology (1950), 2011-03, Vol.186 (5), p.2850-2859

2011

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Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase Response

Molecular and Cellular Biology, 2006-11, Vol.26 (22), p.8655-8665

2006

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mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation

Cells (Basel, Switzerland), 2020-06, Vol.9 (7), p.1567

2020

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The RNA Binding Protein AUF1 Regulates Phosphorylation of The mTORC2 Target Akt

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane

The Journal of biological chemistry, 2022-10, Vol.298 (10), p.102437-102437, Article 102437

2022

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The T-cell receptor signalosome: a dynamic structure with expanding complexity

Current Opinion in Immunology, 2002-06, Vol.14 (3), p.299-305

2002

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Thymocyte-fate decisions: bittersweet new flavor

Blood, 2008-07, Vol.112 (1), p.7-8

Werlen, Guy

2008

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Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis

Neuromolecular medicine, 2024-04, Vol.26 (1), p.10-10, Article 10

2024

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Nature, 2006-12, Vol.444 (7120), p.724-729

2006

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mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation

The Journal of biological chemistry, 2018-10, Vol.293 (42), p.16464-16478

2018

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Mammalian Target of Rapamycin Complex 2 Modulates alpha beta TCR Processing and Surface Expression during Thymocyte Development

The Journal of immunology (1950), 2014-08, Vol.193 (3), p.1162-1170

2014

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Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes

The EMBO journal, 1998-06, Vol.17 (11), p.3101-3111

1998

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Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation

Molecular pharmacology, 1999-11, Vol.56 (5), p.886-894

1999

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A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

Nature (London), 2000-07, Vol.406 (6794), p.422-426

2000

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Abstract 1150: mTORC2 enhances flux through the hexosamine biosynthetic pathway by regulation of GFAT1 expression

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1150-1150

2015

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mTOR complex 2 modulates αβT-cell receptor processing and surface expression during thymocyte development 1

The Journal of immunology (1950), 2014-06, Vol.193 (3), p.1162-1170

2014

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Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.21-21

2016

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mTORC2 Regulation of the Hexosamine Biosynthetic Pathway (HBP) in Response to Nutrients

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Abstract 2441: mTOR complex 2 modulates glycosylation of CD147 via the hexosamine biosynthetic pathway

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2441-2441

2014

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Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development

The Journal of immunology (1950), 2014-08, Vol.193 (3), p.1162-1170

2014

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The Hexosamine Biosynthesis Pathway: Regulation and Function

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

MTOR Signaling and Metabolism in Early T Cell Development

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1

Signaling Life and Death in the Thymus: Timing Is Everything

Fascin1 promotes cell migration of mature dendritic cells

Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase Response

mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation

The RNA Binding Protein AUF1 Regulates Phosphorylation of The mTORC2 Target Akt

The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane

The T-cell receptor signalosome: a dynamic structure with expanding complexity

Thymocyte-fate decisions: bittersweet new flavor

Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation

Mammalian Target of Rapamycin Complex 2 Modulates alpha beta TCR Processing and Surface Expression during Thymocyte Development

Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes

Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

Abstract 1150: mTORC2 enhances flux through the hexosamine biosynthetic pathway by regulation of GFAT1 expression

mTOR complex 2 modulates αβT-cell receptor processing and surface expression during thymocyte development 1

Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels

mTORC2 Regulation of the Hexosamine Biosynthetic Pathway (HBP) in Response to Nutrients

Abstract 2441: mTOR complex 2 modulates glycosylation of CD147 via the hexosamine biosynthetic pathway

Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development

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