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LNA: a versatile tool for therapeutics and genomics

Trends in biotechnology (Regular ed.), 2003-02, Vol.21 (2), p.74-81

2003

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Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

Nucleic acid therapeutics, 2021-12, Vol.31 (6), p.443-456

2021

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Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics

Handbook of experimental pharmacology, 2006 (173), p.405

2006

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LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

Journal of the American Chemical Society, 1998-12, Vol.120 (50), p.13252-13253

1998

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LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA

Biochemistry (Easton), 2004-10, Vol.43 (42), p.13233-13241

2004

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Inhibition of HIV-1 Tat-Dependent Trans Activation by Steric Block Chimeric 2‘-O-Methyl/LNA Oligoribonucleotides

Biochemistry (Easton), 2001-12, Vol.40 (48), p.14645-14654

2001

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Peak tibial acceleration should not be used as indicator of tibial bone loading during running

Sports biomechanics, 2023-01, Vol.ahead-of-print (ahead-of-print), p.1-18

2023

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Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

Accounts of chemical research, 1999-04, Vol.32 (4), p.301-310

Wengel, Jesper

1999

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Sequence and pH Effects of LNA-Containing Triple Helix-Forming Oligonucleotides: Physical Chemistry, Biochemistry, and Modeling Studies

Biochemistry (Easton), 2004-04, Vol.43 (14), p.4160-4169

2004

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Nucleic acid nanotechnology-towards Angstrom-scale engineering

Organic & biomolecular chemistry, 2004-02, Vol.2 (3), p.277-280

Wengel, Jesper

2004

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Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions

Biochemical journal, 2001-03, Vol.354 (Pt 3), p.481-484

2001

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ADAMTS-targeting gapmers as a gene modulation strategy in osteoarthritis

Osteoarthritis and cartilage, 2020-04, Vol.28, p.S521-S522

2020

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Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Journal of controlled release, 2019-01, Vol.294, p.247-258

2019

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Thermodynamic, Counterion, and Hydration Effects for the Incorporation of Locked Nucleic Acid Nucleotides into DNA Duplexes

Biochemistry (Easton), 2006-06, Vol.45 (23), p.7347-7355

2006

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X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

Chemical communications (Cambridge, England), 2001-01 (7), p.651-652

2001

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Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities

Nucleic acids research, 2005-01, Vol.33 (13), p.4223-4234

2005

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LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

Scientific reports, 2017-09, Vol.7 (1), p.11043-16, Article 11043

2017

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The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

PloS one, 2019-02, Vol.14 (2), p.e0211651-e0211651

2019

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CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Nucleic acids research, 2017-05, Vol.45 (9), p.5153-5169

2017

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Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule

Chembiochem : a European journal of chemical biology, 2017-04, Vol.18 (8), p.755-763

2017

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Improved silencing properties using small internally segmented interfering RNAs

Nucleic acids research, 2007-09, Vol.35 (17), p.5886-5897

2007

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α-l-LNA (α-i-r ibo Configured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations

Journal of the American Chemical Society, 2001-08, Vol.123 (30), p.7431-7432

2001

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Biological Activity and Biotechnological Aspects of Locked Nucleic Acids

Advances in Genetics, 2013, Vol.82, p.47-107

2013

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Novel Bicyclic Nucleoside Analogue (1S,5S,6S)-6- Hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: Synthesis and Incorporation into Oligodeoxynucleotides

Journal of organic chemistry, 2001-08, Vol.66 (16), p.5498-5503

2001

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LNA: a versatile tool for therapeutics and genomics

Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics

LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA

Inhibition of HIV-1 Tat-Dependent Trans Activation by Steric Block Chimeric 2‘-O-Methyl/LNA Oligoribonucleotides

Peak tibial acceleration should not be used as indicator of tibial bone loading during running

Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

Sequence and pH Effects of LNA-Containing Triple Helix-Forming Oligonucleotides: Physical Chemistry, Biochemistry, and Modeling Studies

Nucleic acid nanotechnology-towards Angstrom-scale engineering

Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions

ADAMTS-targeting gapmers as a gene modulation strategy in osteoarthritis

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Thermodynamic, Counterion, and Hydration Effects for the Incorporation of Locked Nucleic Acid Nucleotides into DNA Duplexes

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule

Improved silencing properties using small internally segmented interfering RNAs

α-l-LNA (α-i-r ibo Configured Locked Nucleic Acid) Recognition of RNA. A Study by NMR Spectroscopy and Molecular Dynamics Simulations

Biological Activity and Biotechnological Aspects of Locked Nucleic Acids

Novel Bicyclic Nucleoside Analogue (1S,5S,6S)-6- Hydroxy-5-hydroxymethyl-1-(uracil-1-yl)-3,8-dioxabicyclo[3.2.1]octane: Synthesis and Incorporation into Oligodeoxynucleotides

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